Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography.

We demonstrate and compare two image processing methods for visualization and analysis of three-dimensional optical coherence tomography (OCT) data acquired in eyes with different retinal pathologies. A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps. We compare the applicability of the two methods to the diagnosis of retinal diseases and their progression. The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 microm) spectral OCT prototype instrument operating in the ophthalmology clinic.

[1]  J. Duker,et al.  Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. , 2005, Ophthalmology.

[2]  Angelika Unterhuber,et al.  Ultrahigh resolution optical coherence tomography in macular dystrophy. , 2005, American journal of ophthalmology.

[3]  U. Schmidt-Erfurth,et al.  Management of neovascular age-related macular degeneration , 2007, Progress in Retinal and Eye Research.

[4]  David J. Webb,et al.  Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry. , 1998, Journal of biomedical optics.

[5]  Qienyuan Zhou,et al.  Three-dimensional imaging of the human retina by high-speed optical coherence tomography. , 2003, Optics express.

[6]  R. Zawadzki,et al.  Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography. , 2003, Optics express.

[7]  M. Wojtkowski,et al.  Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome , 2008, British Journal of Ophthalmology.

[8]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[9]  Shuliang Jiao,et al.  Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography. , 2005, Optics express.

[10]  C K Hitzenberger,et al.  Dynamic focus in optical coherence tomography for retinal imaging. , 2006, Journal of biomedical optics.

[11]  Wolfgang Drexler,et al.  Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology. , 2005, Ophthalmology.

[12]  Anna Szkulmowska,et al.  Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies. , 2007, Journal of biomedical optics.

[13]  Maciej Wojtkowski,et al.  Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography. , 2009, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[14]  C K Hitzenberger,et al.  Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium , 2008, British Journal of Ophthalmology.

[15]  L. Yannuzzi,et al.  Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy. , 2004, Journal of biomedical optics.

[16]  Angelika Unterhuber,et al.  ULTRAHIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY OF MACULAR HOLES , 2006, Retina.

[17]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[18]  Toyohiko Yatagai,et al.  Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples , 2004 .

[19]  W Drexler,et al.  Ultrahigh resolution Fourier domain optical coherence tomography. , 2004, Optics express.

[20]  R. D. Stulting,et al.  Comparing immersion ultrasound with partial coherence interferometry for intraocular lens power calculation. , 2008, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[21]  T. Yatagai,et al.  Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography. , 2002, Optics letters.

[22]  Teresa C. Chen,et al.  Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography. , 2004, Optics express.

[23]  I. Golbaz,et al.  Neue Perspektiven in der Diagnostik , 2007, Der Ophthalmologe.

[24]  Maciej Wojtkowski,et al.  High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. , 2006, Ophthalmology.

[25]  David A. Jackson,et al.  Three dimensional OCT images from retina and skin. , 2000, Optics express.

[26]  Angelika Unterhuber,et al.  Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections. , 2004, Experimental eye research.

[27]  David A. Jackson,et al.  Combined optical coherence tomograph and scanning laser ophthalmoscope , 1998 .

[28]  Joel S Schuman,et al.  Stage 0 macular holes: observations by optical coherence tomography. , 2004, Ophthalmology.

[29]  Barry Cense,et al.  Birefringence measurements in human skin using polarization-sensitive optical coherence tomography. , 2004, Journal of biomedical optics.

[30]  R. Zawadzki,et al.  Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography. , 2008, Optics letters.

[31]  J. Fujimoto,et al.  Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. , 2003, Archives of ophthalmology.

[32]  J. Duker,et al.  Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. , 2004, Ophthalmology.

[33]  Maciej Wojtkowski,et al.  Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography. , 2008, Investigative ophthalmology & visual science.

[34]  J. Duker,et al.  Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. , 2004, Optics express.

[35]  E Reichel,et al.  Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration , 2008, British Journal of Ophthalmology.