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[1]  M. Cattaneo.  Hereditary defect of the platelet ADP receptor(s). , 2009, Platelets.

[2]  David Julius,et al.  Identification of the platelet ADP receptor targeted by antithrombotic drugs , 2001, Nature.

[3]  S. Offermanns,et al.  ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq. , 2000, Blood.

[4]  R. Evans,et al.  ADP is not an agonist at P2X1 receptors: evidence for separate receptors stimulated by ATP and ADP on human platelets , 2000, British journal of pharmacology.

[5]  S. Hourani,et al.  Platelet P2 receptors: from curiosity to clinical targets. , 2000, Journal of the autonomic nervous system.

[6]  J P Cazenave,et al.  Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. , 1999, The Journal of clinical investigation.

[7]  B. Payrastre,et al.  A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. , 1999, Blood.

[8]  Beverly H. Koller,et al.  Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice , 1999, Nature Medicine.

[9]  C. Gachet,et al.  ADP receptors and clinical bleeding disorders. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[10]  S. Kunapuli,et al.  Multiple P2 receptor subtypes on platelets: a new interpretation of their function. , 1998, Trends in pharmacological sciences.

[11]  T. Egan,et al.  N-Linked glycosylation is essential for the functional expression of the recombinant P2X2 receptor. , 1998, Biochemistry.

[12]  P. Nurden,et al.  Abnormal Tyrosine Phosphorylation Linked to a Defective Interaction between ADP and Its Receptor on Platelets , 1998, Thrombosis and Haemostasis.

[13]  Jess Li,et al.  P2X1 Purinoceptor in Human Platelets , 1998, The Journal of Biological Chemistry.

[14]  G. Dubyak,et al.  The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. , 1998, Blood.

[15]  M. Heath,et al.  Identification of a P2X1 purinoceptor expressed on human platelets. , 1998, Biochemical and biophysical research communications.

[16]  S. Kunapuli,et al.  Molecular Basis for ADP-induced Platelet Activation , 1998, The Journal of Biological Chemistry.

[17]  B. Ashby,et al.  Molecular Basis for ADP-induced Platelet Activation , 1998, The Journal of Biological Chemistry.

[18]  J. Cazenave,et al.  Presence of P2X1 Purinoceptors in Human Platelets and Megakaryoblastic Cell Lines , 1997, Thrombosis and Haemostasis.

[19]  A. Mackenzie,et al.  Purinoceptor-evoked calcium signalling in human platelets. , 1997, Prostaglandins, leukotrienes, and essential fatty acids.

[20]  Stefan Offermanns,et al.  Defective platelet activation in Gαq-deficient mice , 1997, Nature.

[21]  K. Keay,et al.  Structural motif and characteristics of the extracellular domain of P2X receptors. , 1997, Biochemical and biophysical research communications.

[22]  R. Handin.  DAMI cell line. , 1997, Blood.

[23]  N. Greco.  Functional expression of a P2T ADP receptor in Xenopus oocytes injected with megakaryocyte (CMK 11-5) RNA. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[24]  A. Mackenzie,et al.  Activation of Receptor-operated Cation Channels via P Not P Purinoceptors in Human Platelets (*) , 1996, The Journal of Biological Chemistry.

[25]  N. Tandon,et al.  Contributions of glycoprotein Ib and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca2+] induced by alpha-thrombin. , 1996, Biochemistry.

[26]  P. Radziwon,et al.  Two different inhibitory effects of pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid on adenosine diphosphate-induced human platelet aggregation. , 1995, Arzneimittel-Forschung.

[27]  G. Housley,et al.  Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. , 1995, Biochemical and biophysical research communications.

[28]  M. J. Robertson,et al.  A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis. , 1995, Trends in pharmacological sciences.

[29]  P. Leff,et al.  FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T‐purinoceptors , 1994, British journal of pharmacology.

[30]  R. North,et al.  A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP , 1994, Nature.

[31]  D. Julius,et al.  New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor , 1994, Nature.

[32]  S. Hourani,et al.  Receptors for ADP on human blood platelets. , 1994, Trends in pharmacological sciences.

[33]  S. Hourani,et al.  Effects of suramin on increases in cytosolic calcium and on inhibition of adenylate cyclase induced by adenosine 5'-diphosphate in human platelets. , 1994, Biochemical pharmacology.

[34]  N. Tandon,et al.  Low structural specificity for nucleoside triphosphates as antagonists of ADP-induced platelet activation. , 1992, The Journal of biological chemistry.

[35]  S. Sage,et al.  Rapid ADP-evoked currents in human platelets recorded with the nystatin permeabilized patch technique. , 1992, The Journal of biological chemistry.

[36]  S. Hourani,et al.  Effects of the P2‐purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5′‐diphosphate , 1992, British journal of pharmacology.

[37]  M. Moos,et al.  Identification of a nucleotide-binding site on glycoprotein IIb. Relationship to ADP-induced platelet activation. , 1991, The Journal of biological chemistry.

[38]  T. Rink,et al.  SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. , 1990, The Biochemical journal.

[39]  P. Mannucci,et al.  Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates. , 1990, Blood.

[40]  S. Sage,et al.  ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store. , 1990, The Biochemical journal.

[41]  D. Rosenthal,et al.  Characterization of a new megakaryocytic cell line: the Dami cell. , 1988, Blood.

[42]  J. Gorski,et al.  Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. , 1988, The Journal of clinical investigation.

[43]  D. Macfarlane,et al.  The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation. , 1975, Blood.

[44]  K. Schrör.  The basic pharmacology of ticlopidine and clopidogrel. , 1993, Platelets.