Novel Amyloid Precursor Protein Gene Late-Onset Alzheimer ’ s Disease Mutation ( Codon 665 ASP ) in a Patient with

[1]  J. Fink,et al.  ApoE ϵ4 allelic association with Alzheimer's disease , 1994, Neurology.

[2]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[3]  A. Roses,et al.  Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease , 1993, Neurology.

[4]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[5]  S. Younkin,et al.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. , 1993, Science.

[6]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[7]  Y. Agid,et al.  More missense in amyloid gene , 1992, Nature Genetics.

[8]  B. Winblad,et al.  A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid , 1992, Nature Genetics.

[9]  D. Clair,et al.  Mutation in codon 713 of the β amyloid precursor protein gene presenting with schizophrenia , 1992, Nature Genetics.

[10]  U. Schreiter-Gasser,et al.  Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells. , 1992, The Journal of biological chemistry.

[11]  Thomas Wisniewski,et al.  Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.

[12]  J. Hardy,et al.  Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene , 1991, Nature.

[13]  S. Tsuji,et al.  Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease , 1991, The Lancet.

[14]  D. Selkoe.  The molecular pathology of Alzheimer's disease , 1991, Neuron.

[15]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[16]  B. Anderton,et al.  Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion , 1991, Journal of neuroscience research.

[17]  G. Cole,et al.  Amyloid β-protein precursor is associated with extracellular matrix , 1990, Brain Research.

[18]  C. Cotman,et al.  β-Amyloid protein promotes neuritic branching in hippocampal cultures , 1990, Neuroscience Letters.

[19]  K. Johnson-wood,et al.  The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II , 1989, Nature.

[20]  T. Oltersdorf,et al.  Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts , 1989, Cell.

[21]  G. Cole,et al.  Amyloid beta protein precursor is a mitogen. , 1989, Biochemical and biophysical research communications.

[22]  F. Sauvage,et al.  Modification of neuronal cell adhesion affects the genetic expression of the A4 amyloid peptide precursor , 1989, Brain Research.

[23]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[24]  L. Lerman,et al.  DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[25]  F. Giannelli,et al.  Direct sequencing of PCR-amplified DNA. , 1994, Molecular biotechnology.

[26]  B. Greenberg,et al.  A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors , 1988 .

[27]  R. Myers,et al.  Detection and localization of single base changes by denaturing gradient gel electrophoresis. , 1987, Methods in enzymology.

[28]  J. Taylor,et al.  Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. , 1985, Proceedings of the National Academy of Sciences of the United States of America.