Suppression of tissue harmonics for pulse-inversion contrast imaging using time reversal

Pulse-inversion (PI) sequences are sensitive to the nonlinear echoes from microbubbles allowing an improvement in the blood-to-tissue contrast. However, at larger mechanical indices, this contrast is reduced by harmonics produced during nonlinear propagation. A method for tissue harmonics cancellation exploiting time reversal is experimentally implemented using a 128-channel 12-bit emitter receiver. The probe calibration is performed by acquiring the nonlinear echo of a wire in water. These distorted pulses are time-reversed, optimized and used for the PI imaging of a tissue phantom. Compared to normal (straight) pulses, the time-reversed distorted pulses reduced the tissue signal in PI by 11 dB. The second harmonic signals from microbubbles flowing in a wall-less vessel were unaffected by the correction. This technique can thus increase the blood-to-tissue contrast ratio while keeping the pressure and the number of pulses constant.

[1]  Nico de Jong,et al.  Improved contrast to tissue ratio at higher harmonics. , 2002, Ultrasonics.

[2]  A R Jayaweera,et al.  Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. , 1998, Circulation.

[3]  R. Cobbold.  Foundations of Biomedical Ultrasound , 2006 .

[4]  J L Thomas,et al.  Breaking of time reversal invariance in nonlinear acoustics. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[5]  Carlo Bartolozzi,et al.  Tissue harmonic and contrast-specific imaging: back to gray scale in ultrasound , 2002, European Radiology.

[6]  N. Nanda,et al.  Contrast echocardiography: new agents. , 2004, Ultrasound in medicine & biology.

[7]  K. Thomenius,et al.  Improved contrast ultrasound with tissue harmonic minimizing pulse , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[8]  P. Burns,et al.  Microbubble Contrast for Radiological Imaging: 1. Principles , 2006, Ultrasound quarterly.

[9]  Thomas Albrecht,et al.  Improved detection of hepatic metastases with pulse-inversion US during the liver-specific phase of SHU 508A: multicenter study. , 2003, Radiology.

[10]  P. Burns,et al.  Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents , 1997, 1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118).

[11]  D. Cosgrove,et al.  Angiogenesis imaging--ultrasound. , 2003, The British journal of radiology.

[12]  M. O'Donnell,et al.  Suppression of propagating second harmonic in ultrasound contrast imaging , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[13]  M. Schlumberger.  Can iodine-131 whole-body scan be replaced by thyroglobulin measurement in the post-surgical follow-up of differentiated thyroid carcinoma? , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  N de Jong,et al.  Detection procedures of ultrasound contrast agents. , 2000, Ultrasonics.

[15]  D. A. Christopher,et al.  A wall-less vessel phantom for Doppler ultrasound studies. , 1995, Ultrasound in medicine & biology.

[16]  S. Aanonsen,et al.  Distortion and harmonic generation in the nearfield of a finite amplitude sound beam , 1984 .

[17]  Nico de Jong,et al.  "Compression-only" behavior of phospholipid-coated contrast bubbles. , 2007, Ultrasound in medicine & biology.

[18]  L Pourcelot,et al.  Clinical use of ultrasound tissue harmonic imaging. , 1999, Ultrasound in medicine & biology.

[19]  P. Phillips,et al.  Contrast–agent detection and quantification , 2004, European radiology.

[20]  M. Averkiou,et al.  Techniques for perfusion imaging with microbubble contrast agents , 2001, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[21]  Wang Rong-fu.  Quantification of Myocardial Blood Flow With PET , 2007 .