Landscape ecology deals mainly with the spatial pattern, interaction, function and dynamic change of landscape which is composed of various ecosystems. Studies on the impact of human activity on landscape pattern, biological habitat and resource distribution have been a very important field of landscape ecology. In this paper, Dongying region in Yellow river Delta was selected for case study. Four indices such as landscape diversity,landscape dominance, landscape fragmentation and landscape isolation were chosen to analyze quantitatively the rela- tionship between human activity and landscape structure. The landscape diversity in this area decreased with the increase of human activity while the landscape dominance was in a direct proportion to human activity. In this region, the landscape was becoming more fragmented with the strengthening of human activity. There was an inverse relationship between the land- scape isolation and human activity for those man-made landscape types.