Batch fabrication of disposable screen printed SERS arrays.

A novel facile method of fabricating disposable and highly reproducible surface-enhanced Raman spectroscopy (SERS) arrays using screen printing was explored. The screen printing ink containing silver nanoparticles was prepared and printed on supporting materials by a screen printing process to fabricate SERS arrays (6 × 10 printed spots) in large batches. The fabrication conditions, SERS performance and application of these arrays were systematically investigated, and a detection limit of 1.6 × 10(-13) M for rhodamine 6G could be achieved. Moreover, the screen printed SERS arrays exhibited high reproducibility and stability, the spot-to-spot SERS signals showed that the intensity variation was less than 10% and SERS performance could be maintained over 12 weeks. Portable high-throughput analysis of biological samples was accomplished using these disposable screen printed SERS arrays.

[1]  Jian-hui Jiang,et al.  Detection of adenosine using surface-enhanced Raman scattering based on structure-switching signaling aptamer. , 2008, Biosensors & bioelectronics.

[2]  Y. Long,et al.  Facile on-site detection of substituted aromatic pollutants in water using thin layer chromatography combined with surface-enhanced Raman spectroscopy. , 2011, Environmental science & technology.

[3]  Jing Zhao,et al.  Ultrastable substrates for surface-enhanced Raman spectroscopy: Al2O3 overlayers fabricated by atomic layer deposition yield improved anthrax biomarker detection. , 2006, Journal of the American Chemical Society.

[4]  D. Meisel,et al.  Adsorption and surface-enhanced Raman of dyes on silver and gold sols , 1982 .

[5]  Wei W. Yu,et al.  Inkjet printed surface enhanced Raman spectroscopy array on cellulose paper. , 2010, Analytical chemistry.

[6]  S. Beeby,et al.  Processing of PZT piezoelectric thick films on silicon for microelectromechancial systems , 1999 .

[7]  Kan Wang,et al.  Large-scale synthesis of flexible free-standing SERS substrates with high sensitivity: electrospun PVA nanofibers embedded with controlled alignment of silver nanoparticles. , 2009, ACS nano.

[8]  G. Meng,et al.  Ag nanosheet-assembled micro-hemispheres as effective SERS substrates. , 2011, Chemical communications.

[9]  Mingwang Shao,et al.  Highly Reproducible Surface‐Enhanced Raman Scattering on a Capillarity‐Assisted Gold Nanoparticle Assembly , 2011 .

[10]  O. Velev,et al.  Structured Metallic Films for Optical and Spectroscopic Applications via Colloidal Crystal Templating , 2001 .

[11]  R. Fedosejevs,et al.  Surface-Enhanced Raman Scattering (SERS) Detection of Low Concentrations of Tryptophan Amino Acid in Silver Colloid , 2011, Applied spectroscopy.

[12]  Jürgen Popp,et al.  A reproducible surface-enhanced raman spectroscopy approach. Online SERS measurements in a segmented microfluidic system. , 2007, Analytical chemistry.

[13]  Chad A Mirkin,et al.  Rationally designed nanostructures for surface-enhanced Raman spectroscopy. , 2008, Chemical Society reviews.

[14]  Jianping Xie,et al.  The synthesis of SERS-active gold nanoflower tags for in vivo applications. , 2008, ACS nano.

[15]  Edgar Voges,et al.  Periodically structured metallic substrates for SERS , 1998 .

[16]  M. Geissler,et al.  Plastic Substrates for Surface-Enhanced Raman Scattering , 2009 .

[17]  A. Ganesan,et al.  Influence of functional groups on the Cα―Cβ chain of L-phenylalanine and its derivatives , 2010 .

[18]  Camelia Bala,et al.  Biosensors based on screen-printing technology, and their applications in environmental and food analysis , 2007, Analytical and bioanalytical chemistry.

[19]  Y. Long,et al.  Multiple depositions of Ag nanoparticles on chemically modified agarose films for surface-enhanced Raman spectroscopy. , 2012, Nanoscale.

[20]  Luke P. Lee,et al.  Nanowell surface enhanced Raman scattering arrays fabricated by soft-lithography for label-free biomolecular detections in integrated microfluidics , 2005 .

[21]  S. Cho,et al.  Screen printing of silver nanoparticle suspension for metal interconnects , 2008 .

[22]  M. Sepaniak,et al.  Surface-enhanced Raman spectroscopy substrates created via electron beam lithography and nanotransfer printing. , 2008, ACS nano.

[23]  J. Baumberg,et al.  Quantitative electrochemical SERS of flavin at a structured silver surface. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[24]  Zhong Lin Wang,et al.  Shell-isolated nanoparticle-enhanced Raman spectroscopy , 2010, Nature.

[25]  Hyeon-Cheol Choi,et al.  Color filter patterned by screen printing , 2008 .

[26]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[27]  J Wang,et al.  Screen-printable sol-gel enzyme-containing carbon inks. , 1996, Analytical chemistry.

[28]  Don L DeVoe,et al.  Nanoparticle-functionalized porous polymer monolith detection elements for surface-enhanced Raman scattering. , 2011, Analytical chemistry.

[29]  Ajay Agarwal,et al.  Label-free and highly sensitive biomolecular detection using SERS and electrokinetic preconcentration. , 2009, Lab on a chip.

[30]  K. Soo,et al.  Deposition method for preparing SERS-active gold nanoparticle substrates. , 2005, Analytical chemistry.

[31]  I Karube,et al.  A glucose sensor fabricated by the screen printing technique. , 1995, Biosensors & bioelectronics.

[32]  Z. Geng,et al.  A route to apply Ag nanoparticle array integrated with microfluidic for surface enhanced Raman scattering , 2011 .

[33]  Meikun Fan,et al.  Multilayer silver nanoparticles-modified optical fiber tip for high performance SERS remote sensing. , 2010, Biosensors & bioelectronics.

[34]  B. Sexton,et al.  Silica‐overcoated substrates for detection of proteins by surface‐enhanced Raman spectroscopy , 2008 .

[35]  K. Yang,et al.  A new strategy to prepare surface-enhanced Raman scattering-active substrates by electrochemical pulse deposition of gold nanoparticles. , 2011, Chemical communications.

[36]  Nasser N Peyghambarian,et al.  Application of Screen Printing in the Fabrication of Organic Light‐Emitting Devices , 2000 .

[37]  Zhong-Qun Tian,et al.  Surface-enhanced Raman spectroscopy: substrate-related issues , 2009, Analytical and bioanalytical chemistry.

[38]  Jaebum Choo,et al.  A portable surface-enhanced Raman scattering sensor integrated with a lab-on-a-chip for field analysis. , 2008, Lab on a chip.

[39]  M. Moskovits.  Surface‐enhanced Raman spectroscopy: a brief retrospective , 2005 .

[40]  Ilaria Palchetti,et al.  Disposable strip potentiometric electrodes with solvent-polymeric ion-selective membranes fabricated using screen-printing technology , 1999 .

[41]  Younan Xia,et al.  Langmuir-Blodgett Silver Nanowire Monolayers for Molecular Sensing Using Surface-Enhanced Raman Spectroscopy , 2003 .

[42]  Dan Li,et al.  Cyclic electroplating and stripping of silver on Au@SiO2 core/shell nanoparticles for sensitive and recyclable substrate of surface-enhanced Raman scattering , 2010 .

[43]  M. Porter,et al.  Low-level detection of viral pathogens by a surface-enhanced Raman scattering based immunoassay. , 2005, Analytical chemistry.