The clinical effectiveness and cost-effectiveness of bupropion and nicotine replacement therapy for smoking cessation: a systematic review and economic evaluation.

Specific interventions included in the review Studies were included if they examined bupropion (150 or 300 mg/day) immediate release and SR formulations, used to aid smoking cessation alone, or as part of combination therapy with motivational support, or as part of combination therapy with motivational support and NRT. The main comparator was placebo, but other eligible comparators were no treatment, other pharmacological agents, and non-pharmacological interventions such as acupuncture.

[1]  A. McDonald,et al.  Efficacy and safety of an over-the-counter transdermal nicotine patch as an aid for smoking cessation. , 1998, Archives of family medicine.

[2]  D. Schroeder,et al.  High-dose nicotine patch therapy. Percentage of replacement and smoking cessation. , 1995, JAMA.

[3]  G. Gardos.  Reversible dyskinesia during bupropion therapy. , 1997, The Journal of clinical psychiatry.

[4]  R. Segraves,et al.  Double-blind comparison of bupropion sustained release and sertraline in depressed outpatients. , 1997, The Journal of clinical psychiatry.

[5]  K. Preston,et al.  Safety and Efficacy of Bupropion Combined With Bromocriptine for Treatment of Cocaine Dependence , 1996 .

[6]  M. Halpern,et al.  Economic model of sustained-release bupropion hydrochloride in health plan and work site smoking-cessation programs. , 2000, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[7]  L. Gunning-Schepers,et al.  The health benefits of prevention: a simulation approach. , 1988, Health policy.

[8]  G. Gustavsson,et al.  Targeting heavy smokers in general practice: randomised controlled trial of transdermal nicotine patches. , 1993, BMJ.

[9]  G. Levin,et al.  Mania with Bupropion: A Dose-Related Phenomenon? , 2000, The Annals of pharmacotherapy.

[10]  R. Marks,et al.  Transdermal nicotine suppresses cutaneous inflammation. , 1997, Archives of Dermatology.

[11]  Jarvik Me,et al.  Nicotine gum vs. placebo gum: comparisons of withdrawal symptoms and success rates. , 1985 .

[12]  D. Ames,et al.  Organic mental disorders associated with bupropion in three patients. , 1992, The Journal of clinical psychiatry.

[13]  C. McBride,et al.  Smoking cessation in women concerned about weight. , 1992, American journal of public health.

[14]  Gwendolyn H Thompson,et al.  Nicotine Replacement Therapy , 1998, The Annals of pharmacotherapy.

[15]  M. Prevo,et al.  Absorption and adverse effects following topical and oral administration of three transdermal nicotine products to dogs. , 1995, Journal of pharmaceutical sciences.

[16]  J. Hirsch,et al.  A randomized, double-blind, placebo-controlled clinical evaluation of a nicotine sublingual tablet in smoking cessation. , 2000, Addiction.

[17]  K. Fagerström.  A comparison of psychological and pharmacological treatment in smoking cessation , 1982, Journal of Behavioral Medicine.

[18]  M. Jarvik,et al.  Smoking Status and Nicotine Administration Differentially Modify Hemodynamic Stress Reactivity in Men and Women , 1997, Psychosomatic medicine.

[19]  T. Blöndal.  Controlled trial of nicotine polacrilex gum with supportive measures. , 1989, Archives of internal medicine.

[20]  T. van Putten,et al.  Delirium associated with bupropion. , 1990, Journal of clinical psychopharmacology.

[21]  T. Wenger,et al.  The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. , 1994, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[22]  N. Benowitz,et al.  Dose‐related cardiovascular and endocrine effects of transdermal nicotine , 1998, Clinical pharmacology and therapeutics.

[23]  N. Miller,et al.  Women's initiative for nonsmoking (WINS) II: the intervention. , 2000, Heart & lung : the journal of critical care.

[24]  Stewart Mj,et al.  A controlled trial of nicotine chewing gum in a smoking withdrawal clinic. , 1982 .

[25]  T. Kosten,et al.  An open pilot study of bupropion and psychotherapy for the treatment of cocaine abuse in methadone-maintained patients. , 1990, NIDA research monograph.

[26]  A. Keren,et al.  Effects of transdermal nicotine patches on ambulatory ECG monitoring findings: A double-blind study in healthy smokers , 1996, Cardiovascular Drugs and Therapy.

[27]  P. Tønnesen,et al.  Predictors and reasons for relapse in smoking cessation with nicotine and placebo patches. , 1993, Preventive medicine.

[28]  J. Hughes.  Risk-Benefit Assessment of Nicotine Preparations in Smoking Cessation , 1993, Drug Safety.

[29]  E. Levin,et al.  Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence , 1992, Pharmacology Biochemistry and Behavior.

[30]  F. Cusano,et al.  Allergic contact dermatitis from transdermal nicotine systems , 1993, Contact dermatitis.

[31]  M. Jarvik,et al.  Combined use of alcohol and nicotine gum. , 1991, Addictive behaviors.

[32]  J. Warnock,et al.  Treatment Augmentation With Opiates in Severe and Refractory Major Depression , 1999, American Journal of Psychiatry.

[33]  G. Gustavsson,et al.  Importance of baseline cotinine plasma values in smoking cessation: results from a double-blind study with nicotine patch. , 1996, The European respiratory journal.

[34]  P. Chappell,et al.  Bupropion and compulsive behavior. , 1994, Journal of the American Academy of Child and Adolescent Psychiatry.

[35]  D. Kirksey,et al.  Private practice evaluation of the safety and efficacy of bupropion in depressed outpatients. , 1983, The Journal of clinical psychiatry.

[36]  D. Cook,et al.  Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies. , 2000, Archives of internal medicine.

[37]  Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up , 1999 .

[38]  R. Nelson,et al.  Effects of Bupropion Sustained-Release on Sexual Functioning and Nocturnal Erections in Healthy Men , 2001, Journal of clinical psychopharmacology.

[39]  M. Borenstein,et al.  Safety and efficacy of bupropion in elderly patients: preliminary observations. , 1983, The Journal of clinical psychiatry.

[40]  S. Leischow,et al.  Efficacy of the Nicotine Inhaler as an Adjunct to Smoking Cessation , 1996 .

[41]  A. Bohadana,et al.  Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation: a randomized, double-blind, placebo-controlled trial. , 2000, Archives of internal medicine.

[42]  N. Benowitz,et al.  Risks and Benefits of Nicotine to Aid Smoking Cessation in Pregnancy , 2001, Drug safety.

[43]  G. Y. Wong,et al.  A randomized trial of naltrexone for smoking cessation. , 1999, Addiction.

[44]  R. Hurt,et al.  Nicotine nasal spray for smoking cessation: pattern of use, side effects, relief of withdrawal symptoms, and cotinine levels. , 1998, Mayo Clinic proceedings.

[45]  R. Olmstead,et al.  Efficacy of a nicotine inhaler in smoking cessation: a double-blind, placebo-controlled trial. , 1996, Addiction.

[46]  R. Starbuck,et al.  Methodologic approach to adverse events applied to bupropion clinical trials. , 1983, The Journal of clinical psychiatry.

[47]  N. Benowitz,et al.  Cardiovascular toxicity of nicotine: implications for nicotine replacement therapy. , 1997, Journal of the American College of Cardiology.

[48]  T. Abelin,et al.  Effectiveness of a transdermal nicotine system in smoking cessation studies. , 1989, Methods and findings in experimental and clinical pharmacology.

[49]  Qi Zhang,et al.  Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. , 1993, Journal of the American College of Cardiology.

[50]  J. Olsen,et al.  [The effect of transdermal nicotine patches in smoking cessation. A randomized trial in pharmacy customers in Denmark]. , 1999, Ugeskrift for laeger.

[51]  Å. Westin,et al.  Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety , 2000, BMJ : British Medical Journal.

[52]  R. Hurt,et al.  Nicotine-replacement therapy with use of a transdermal nicotine patch--a randomized double-blind placebo-controlled trial. , 1990, Mayo Clinic proceedings.

[53]  D. Hatsukami,et al.  Cholesterol changes in smoking cessation using the transdermal nicotine system. Transdermal Nicotine Study Group. , 1994, Preventive medicine.

[54]  M. D. Banov,et al.  A double-blind trial of bupropion versus desipramine for bipolar depression. , 1994, The Journal of clinical psychiatry.

[55]  Nowlin Ns.  Anorexia Nervosa in twins: case report and review. , 1983 .

[56]  G. Oster,et al.  Cost-effectiveness of nicotine gum as an adjunct to physician's advice against cigarette smoking. , 1986, JAMA.

[57]  K. Fagerström.  Tolerance, withdrawal and dependence on tobacco and smoking termination , 1983 .

[58]  A. Forbes,et al.  Double blind trial of repeated treatment with transdermal nicotine for relapsed smokers , 1995, BMJ.

[59]  U. Bjornsdottir,et al.  The effects of fluoxetine combined with nicotine inhalers in smoking cessation--a randomized trial. , 1999, Addiction.

[60]  R. Dahl,et al.  Effect of nicotine, silver acetate, and ordinary chewing gum in combination with group counselling on smoking cessation. , 1990, Thorax.

[61]  M. Raw,et al.  Nicotine chewing gum in general practice: effect of follow up appointments. , 1985, British medical journal.

[62]  T. Flotte,et al.  Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function. , 2000, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

[63]  M. E. Wewers.  Current Concepts in Smoking Cessation and Preventive Strategies , 1999 .

[64]  H. Spiller,et al.  Bupropion overdose: a 3-year multi-center retrospective analysis. , 1994, The American journal of emergency medicine.

[65]  J. Thornby,et al.  The hemodynamic and hematologic effects of cigarette smoking versus a nicotine patch. , 1995, Plastic and reconstructive surgery.

[66]  W. Follette,et al.  Transdermal nicotine: The long and the short of it. , 1999 .

[67]  C. Feyerabend,et al.  Transdermal nicotine patches with low-intensity support to aid smoking cessation in outpatients in a general hospital. A placebo-controlled trial. , 1993, Archives of family medicine.

[68]  W. Potter,et al.  Psychoses associated with bupropion treatment. , 1985, The American journal of psychiatry.

[69]  Warren C. Stern,et al.  Effects of bupropion on body weight. , 1983, The Journal of clinical psychiatry.

[70]  J. Feighner,et al.  A fixed-dose (300 mg) efficacy study of bupropion and placebo in depressed outpatients. , 1990, The Journal of clinical psychiatry.

[71]  M. Jarvik,et al.  Nicotine gum vs. placebo gum: comparisons of withdrawal symptoms and success rates. , 1985, NIDA research monograph.

[72]  D. Hatsukami,et al.  The smoking cessation efficacy of varying doses of nicotine patch delivery systems 4 to 5 years post-quit day. , 1999, Preventive medicine.

[73]  R. West,et al.  Randomized comparative trial of nicotine polacrilex, a transdermal patch, nasal spray, and an inhaler. , 1999, Archives of internal medicine.

[74]  P. Tønnesen,et al.  A double-blind trial of a nicotine inhaler for smoking cessation. , 1993, JAMA.

[75]  P. Riggs,et al.  An open trial of bupropion for ADHD in adolescents with substance use disorders and conduct disorder. , 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

[76]  P. Sanberg,et al.  Case study: long-term potentiation of neuroleptics with transdermal nicotine in Tourette's syndrome. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[77]  M. Weinstein,et al.  Cost-effectiveness of a smoking cessation program after myocardial infarction. , 1993, Journal of the American College of Cardiology.

[78]  S. Benhamou,et al.  Helping people to stop smoking: randomised comparison of groups being treated with acupuncture and nicotine gum with control group. , 1985, British medical journal.

[79]  C. J. Jiménez Ruiz,et al.  Smoking cessation with a 16 h nicotine patch: results in a group of hospital workers. , 1997, The European respiratory journal.

[80]  S. Hall,et al.  Nicotine gum and behavioral treatment in smoking cessation. , 1985 .

[81]  N. Anthonisen,et al.  Interventions for smoking cessation: the outcomes are determined by the questions asked. , 1999, The European respiratory journal.

[82]  J. Zacny,et al.  Abuse Potential of Nicotine Replacement Therapies , 1995 .

[83]  M. Raw,et al.  Randomised controlled trial of nicotine chewing-gum. , 1982, British medical journal.

[84]  J. McCarten,et al.  Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety , 1995, Pharmacology Biochemistry and Behavior.

[85]  R. Richmond.  A comparison of measures used to assess effectiveness of the transdermal nicotine patch at 1 year. , 1997, Addictive behaviors.

[86]  L. Fabre,et al.  Comparative efficacy and safety of bupropion and placebo in the treatment of depression , 2004, Psychopharmacology.

[87]  S. Fortmann,et al.  Nicotine patch and self-help video for cigarette smoking cessation. , 1997, Journal of consulting and clinical psychology.

[88]  K. Kostner,et al.  Contribution of nicotine to acute endothelial dysfunction in long-term smokers. , 2002, Journal of the American College of Cardiology.

[89]  W. Wadland,et al.  Enhancing smoking cessation of low-income smokers in managed care. , 2001, The Journal of family practice.

[90]  R. Newcombe,et al.  Transdermal nicotine as maintenance therapy for ulcerative colitis. , 1995, The New England journal of medicine.

[91]  R. Schlegel,et al.  Smoking cessation in family practice: the effects of advice and nicotine chewing gum prescription. , 1986, Addictive behaviors.

[92]  D. Wetter,et al.  Two studies of the clinical effectiveness of the nicotine patch with different counseling treatments. , 1994, Chest.

[93]  Fawcett Rg.  Cerebral infarct presenting as mania. , 1991 .

[94]  F. Clavel-Chapelon,et al.  Smoking cessation rates 4 years after treatment by nicotine gum and acupuncture. , 1997, Preventive medicine.

[95]  P. Gariti,et al.  The relationship between psychopathology and smoking cessation treatment response. , 2000, Drug and alcohol dependence.

[96]  M. Fiore,et al.  Helping Wisconsin women quit smoking: a successful collaboration. , 2000, WMJ : official publication of the State Medical Society of Wisconsin.

[97]  A. Arrazola,et al.  An evidence-based programme for smoking cessation: effectiveness in routine general practice. , 2000, The British journal of general practice : the journal of the Royal College of General Practitioners.

[98]  A. Buist,et al.  Nicotine gum use in the first year of the Lung Health Study. , 1993, Addictive behaviors.

[99]  D. Abrams,et al.  Matching high- and low-dependence smokers to self-help treatment with or without nicotine replacement. , 1994, Preventive medicine.

[100]  S. Curry,et al.  Self-help interventions for smoking cessation. , 1993, Journal of consulting and clinical psychology.

[101]  B. Rimer,et al.  Use of transdermal nicotine in a state-level prescription plan for the elderly. A first look at 'real-world' patch users. , 1994, JAMA.

[102]  C. Spencer,et al.  Bupropion , 2000, Drugs.

[103]  K. Fagerström,et al.  Cessation of long-term nicotine gum use--a prospective, randomized trial. , 1995, Addiction.

[104]  A. Joseph,et al.  Lack of efficacy of transdermal nicotine in smoking cessation. , 1999, The New England journal of medicine.

[105]  D. Schroeder,et al.  Nicotine patch use in pregnant smokers: nicotine and cotinine levels and fetal effects. , 1999, American journal of obstetrics and gynecology.

[106]  L. Labbate.  Bupropion-SR-induced increased libido and spontaneous orgasm. , 1998, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[107]  D. Huber,et al.  Combined and Separate Treatment Effects of Nicotine Chewing Gum and Self-Control Method , 1988, Pharmacopsychiatry.

[108]  J. Hughes,et al.  Effect of dose on nicotine's reinforcing, withdrawal-suppression and self-reported effects. , 1990, The Journal of pharmacology and experimental therapeutics.

[109]  R. Remick,et al.  A comparison of the safety and efficacy of bupropion HCL and amitriptyline HCL in depressed outpatients , 1982, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[110]  A. W. Peck,et al.  Effects of bupropion, nomifensine and dexamphetamine on performance, subjective feelings, autonomic variables and electroencephalogram in healthy volunteers. , 1983, British journal of clinical pharmacology.

[111]  D. Ferry,et al.  Usage patterns of transdermal nicotine when purchased as a non-prescription medicine from pharmacies , 1998, Tobacco control.

[112]  B. Steele,et al.  The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. , 1996, The New England journal of medicine.

[113]  E. Vartiainen,et al.  Combined use of nicotine patch and gum compared with gum alone in smoking cessation - a clinical trial in North Karelia , 1995 .

[114]  R. West,et al.  Individual differences in preferences for and responses to four nicotine replacement products , 2000, Psychopharmacology.

[115]  R. Richmond,et al.  Effectiveness of a 24-hour transdermal nicotine patch in conjunction with a cognitive behavioural programme: one year outcome. , 1997, Addiction.

[116]  S. Vukusic,et al.  Nicotine et aggravation de la myasthénie , 1997 .

[117]  Adverse Drug Reaction , 1998 .

[118]  M. Fiore,et al.  Response to nicotine dependence treatment in smokers with current and past alcohol problems , 1999, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[119]  S. Hall,et al.  Development of major depression after treatment for smoking cessation. , 2000, The American journal of psychiatry.

[120]  Warren C. Stern,et al.  Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. , 1983, The Journal of clinical psychiatry.

[121]  C. Taylor,et al.  Nicotine gum and self-regulation training in smoking relapse prevention , 1984 .

[122]  M. Horstmann,et al.  Combination of behavioral smoking cessation with transdermal nicotine substitution. , 1989, Addictive behaviors.

[123]  Camellia P. Clark,et al.  The Effects of Transdermal Nicotine Therapy for Smoking Cessation on Depressive Symptoms in Patients with Major Depression , 2001, Neuropsychopharmacology.

[124]  J. E. Anderson,et al.  Transdermal nicotine replacement for hospitalized patients: a randomized clinical trial. , 1998, Preventive medicine.

[125]  P. Masand,et al.  Bupropion and secondary mania. Is there a relationship? , 1993, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[126]  V. S. Anand,et al.  Evaluating the tolerability of the newer antidepressants. , 1999, The Journal of nervous and mental disease.

[127]  C. Bolliger.  Practical experiences in smoking reduction and cessation. , 2000, Addiction.

[128]  D. Mays,et al.  The Effect of Mesalamine and Nicotine in the Treatment of Inflammatory Bowel Disease , 1997, The Annals of pharmacotherapy.

[129]  M. Russell,et al.  How much does relapse after one year erode effectiveness of smoking cessation treatments? Long term follow up of randomised trial of nicotine nasal spray , 1998, BMJ.

[130]  P. Tønnesen,et al.  A double-blind trial of a 16-hour transdermal nicotine patch in smoking cessation. , 1991, The New England journal of medicine.

[131]  Y. Chien,et al.  The nicotine transdermal system. , 1998, Clinics in dermatology.

[132]  M. Verani,et al.  Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia. , 1997, Journal of the American College of Cardiology.

[133]  C. Kellner,et al.  Bupropion coadministration with electroconvulsive therapy: two case reports. , 1994, Journal of clinical psychopharmacology.

[134]  M. Fiore,et al.  Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain , 1996, Psychopharmacology.

[135]  J. P. Mckenna,et al.  Are higher doses of nicotine replacement more effective for smoking cessation? , 1999, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[136]  J. Wahlberg,et al.  Reactivity to nicotine patches wrongly blamed on contact allergy , 1997, Contact dermatitis.

[137]  E. Waters,et al.  Interventions for promoting smoking cessation during pregnancy. , 2000, The Cochrane database of systematic reviews.

[138]  J. Mendels,et al.  A comparative study of bupropion and amitriptyline in depressed outpatients. , 1983, The Journal of clinical psychiatry.

[139]  D. Schroeder,et al.  Over-the-counter nicotine patch therapy for smoking cessation: results from randomized, double-blind, placebo-controlled, and open label trials. , 1999, American journal of public health.

[140]  R. Sillett,et al.  The use of nicotine chewing gum as an aid to stopping smoking , 2004, Psychopharmacology.

[141]  E. Levin,et al.  Transdermal nicotine facilitates smoking cessation , 1990, Clinical pharmacology and therapeutics.

[142]  M. Smith,et al.  Pharmacoeconomic analysis of smoking-cessation interventions. , 1996, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[143]  S. Sutton,et al.  Randomized trial of brief individual treatment for smoking using nicotine chewing gum in a workplace setting. , 1987, American journal of public health.

[144]  M. Fiore,et al.  Profiles in discouragement: two studies of variability in the time course of smoking withdrawal symptoms. , 1998, Journal of abnormal psychology.

[145]  A. Leuchter,et al.  Falling backward in two elderly patients taking bupropion. , 1992, The Journal of clinical psychiatry.

[146]  B. J. Sudan.  Nicotine skin patch treatment and adverse reactions: skin irritation, skin sensitization, and nicotine as a hapten. , 1995, Journal of clinical psychopharmacology.

[147]  C. Cabezas,et al.  Does nurse counseling or offer of nicotine gum improve the effectiveness of physician smoking-cessation advice? , 1992, Family practice research journal.

[148]  J. Connett,et al.  Design and results of the initial intervention program for the Lung Health Study. The Lung Health Study Research Group. , 1993, Preventive medicine.

[149]  J. Punnotok,et al.  Smoking cessation through the use of nicotine chewing gum: a double-blind trial in Thailand. , 1988, Clinical therapeutics.

[150]  P. Hayes,et al.  Adverse reactions to five new antidepressants. , 1986, Clinical pharmacy.

[151]  S. Leischow,et al.  OTC Nicotine Patch: Effectiveness Alone and with Brief Physician Intervention , 1999 .

[152]  Weng Tl,et al.  The cardiovascular profile of bupropion. , 1983 .

[153]  S. Finkel.  Efficacy and tolerability of antidepressant therapy in the old-old. , 1996, The Journal of clinical psychiatry.

[154]  R. Buchanan,et al.  Effects of sustained-release bupropion and supportive group therapy on cigarette consumption in patients with schizophrenia. , 2001, The American journal of psychiatry.

[155]  E. A. Brown,et al.  A double-blind study comparing idazoxan and bupropion in bipolar depressed patients. , 1999, Journal of affective disorders.

[156]  S. Fortmann,et al.  Minimal contact treatment for smoking cessation. A placebo controlled trial of nicotine polacrilex and self-directed relapse prevention: initial results of the Stanford Stop Smoking Project. , 1988, JAMA.

[157]  L. Ferry.  Non-nicotine pharmacotherapy for smoking cessation. , 1999, Primary care.

[158]  P. Greenberger,et al.  Bupropion hydrochloride induced serum sickness-like reaction. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[159]  Warren C. Stern,et al.  Long-term efficacy and safety of bupropion. , 1983, The Journal of clinical psychiatry.

[160]  M. McNabb.  Chewing nicotine gum for 3 months: what happens to plasma nicotine levels? , 1984, Canadian Medical Association journal.

[161]  Richard Doll,et al.  Mortality in relation to smoking: 22 years' observations on female British doctors. , 1980, British medical journal.

[162]  J. Davidson,et al.  A double-blind comparison of bupropion and amitriptyline in depressed inpatients. , 1983, The Journal of clinical psychiatry.

[163]  John C. Morris,et al.  TRANSDERMAL NICOTINE TREATMENT FOR ULCERATIVE-COLITIS-A CONTROLLED TRIAL , 1993 .

[164]  M. J. Stewart,et al.  A controlled trial of nicotine chewing gum in a smoking withdrawal clinic. , 1982, The Practitioner.

[165]  S. Preskorn.  Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine. , 1995, The Journal of clinical psychiatry.

[166]  J. Davidson,et al.  Bupropion and sexual function: a placebo-controlled prospective study on diabetic men with erectile dysfunction. , 1997, Journal of clinical psychopharmacology.

[167]  T. Blondal,et al.  Papers , 1999, BMJ.

[168]  L. Stead,et al.  Mecamylamine (a nicotine antagonist) for smoking cessation. , 1998, The Cochrane database of systematic reviews.

[169]  J. Feighner,et al.  Double-blind comparison of bupropion and fluoxetine in depressed outpatients. , 1991, The Journal of clinical psychiatry.

[170]  T. Lancaster,et al.  Which smokers are helped to give up smoking using transdermal nicotine patches? Results from a randomized, double-blind, placebo-controlled trial. , 1996, The British journal of general practice : the journal of the Royal College of General Practitioners.

[171]  G. Oster,et al.  The cost-effectiveness of counseling smokers to quit. , 1989, JAMA.

[172]  B. Stamford,et al.  Effects of the transdermal nicotine patch on normalization of HDL-C and its subfractions. , 2000, Preventive medicine.

[173]  D. Sepinwall,et al.  Free nicotine patches plus proactive telephone peer support to help low-income women stop smoking. , 2000, Preventive medicine.

[174]  Lydiard Rb.  Desipramine-associated SIADH in an elderly woman: case report. , 1983 .

[175]  K. Fagerström,et al.  Nicotine gum, 2 and 4 mg, for nicotine dependence. A double-blind placebo-controlled trial within a behavior modification support program. , 1995, Chest.

[176]  S. Leischow,et al.  Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling. , 1993, Archives of internal medicine.

[177]  L. Lind,et al.  Short-term effects of smoking and nicotine chewing gum on endothelium-dependent vasodilation in young healthy habitual smokers. , 2000, Journal of cardiovascular pharmacology.

[178]  S Shiffman,et al.  The efficacy of computer-tailored smoking cessation material as a supplement to nicotine polacrilex gum therapy. , 2000, Archives of internal medicine.

[179]  J M Ferguson,et al.  Treatment of bulimia with bupropion: a multicenter controlled trial. , 1988, The Journal of clinical psychiatry.

[180]  E. Levin,et al.  The nicotine patch in smoking cessation. A randomized trial with telephone counseling. , 1993, Archives of internal medicine.

[181]  Nicotine patch and paroxetine for smoking cessation. , 2000 .

[182]  P. Hajek,et al.  Long-term use of nicotine chewing gum. Occurrence, determinants, and effect on weight gain. , 1988 .

[183]  A. Lowin,et al.  Prescription of transdermal nicotine patches for smoking cessation in general practice: evaluation of cost-effectiveness , 1999, The Lancet.

[184]  G. Kanel,et al.  CASE REPORT: Acute Hepatitis Induced by Bupropion , 2000, Digestive Diseases and Sciences.

[185]  R. Leigh,et al.  Nicotine replacement combined with a novel compound (ProBAN) for smoking cessation: a pilot study. , 2001, Canadian respiratory journal.

[186]  A. Einarson,et al.  Hiccups following Nicotine Gum Use , 1997, The Annals of pharmacotherapy.

[187]  J. Saucier,et al.  ECG conduction delays associated with massive bupropion overdose. , 1998, Journal of toxicology. Clinical toxicology.

[188]  G. Robinson,et al.  The safety, tolerability and efficacy of transdermal nicotine (Nicotinell TTS) in initially hospitalised patients. , 1995, The New Zealand medical journal.

[189]  M. Jarvik,et al.  Nicotine gum in smoking cessation: a placebo-controlled, double-blind trial. , 1983, Addictive behaviors.

[190]  P. J. van der Maas,et al.  The health care costs of smoking. , 1997, The New England journal of medicine.

[191]  E. Settle.  Bupropion sustained release: side effect profile. , 1998, The Journal of clinical psychiatry.

[192]  R. Ebert,et al.  Plasma nicotine levels produced by chewing nicotine gum. , 1982, JAMA.

[193]  S. Fortmann,et al.  Do heavy smokers benefit from higher dose nicotine patch therapy? , 1999, Experimental and clinical psychopharmacology.

[194]  N. Anthonisen,et al.  Characteristics of participants who stop smoking and sustain abstinence for 1 and 5 years in the Lung Health Study. , 2000, Preventive medicine.

[195]  D. Wetter,et al.  Smoking cessation. 2: Components of effective intervention. , 1997, Behavioral medicine.

[196]  Iain Crombie,et al.  The pocket guide to critical appraisal. , 1996 .

[197]  F. Vázquez,et al.  Smoking Cessation Treatments in Spain. a Thirty-Year Perspective: 1966–1996 , 2000, Substance use & misuse.

[198]  S. Fortmann,et al.  Evaluation of a treatment approach combining nicotine gum with self-guided behavioral treatments for smoking relapse prevention. , 1990, Journal of consulting and clinical psychology.

[199]  P. Goodnick.  Acute and Long-Term Bupropion Therapy: Response and Side Effects , 1991 .

[200]  S. Kimmel,et al.  Risk of acute first myocardial infarction and use of nicotine patches in a general population. , 2001, Journal of the American College of Cardiology.

[201]  M. Russell,et al.  Effect of nicotine chewing gum as an adjunct to general practitioner's advice against smoking. , 1983 .

[202]  R. Donahue,et al.  Bupropion sustained release versus paroxetine for the treatment of depression in the elderly. , 2000, The Journal of clinical psychiatry.

[203]  R. Herning,et al.  Electroencephalographic effects of nicotine chewing gum in humans , 1986, Pharmacology Biochemistry and Behavior.

[204]  C. Patten,et al.  Effect of three smoking cessation treatments on nicotine withdrawal in 141 abstinent alcoholic smokers. , 2000, Addictive behaviors.

[205]  P. Cinciripini,et al.  Behavior therapy and the transdermal nicotine patch: effects on cessation outcome, affect, and coping. , 1996, Journal of consulting and clinical psychology.

[206]  Z. Shnek,et al.  A critical review of research related to family physician-assisted smoking cessation interventions. , 1997, Cancer prevention & control : CPC = Prevention & controle en cancerologie : PCC.

[207]  J. Susman,et al.  Transdermal nicotine therapy and primary care. Importance of counseling, demographic, and participant selection factors on 1-year quit rates. The Nebraska Primary Practice Smoking Cessation Trial Group. , 1998, Archives of family medicine.

[208]  J. Feighner,et al.  Double-blind comparison of doxepin versus bupropion in outpatients with a major depressive disorder. , 1986, Journal of clinical psychopharmacology.

[209]  N. Benowitz,et al.  The Benefits of Stopping Smoking and the Role of Nicotine Replacement Therapy in Older Patients , 1996, Drugs & aging.

[210]  A. Bircher,et al.  Adverse skin reactions to nicotine in a transdermal therapeutic system , 1991, Contact dermatitis.

[211]  P. Franks,et al.  Cost-effectiveness of the transdermal nicotine patch as an adjunct to physicians' smoking cessation counseling. , 1996, JAMA.

[212]  Å. Westin,et al.  Effect of nicotine nasal spray on smoking cessation. A randomized, placebo-controlled, double-blind study. , 1994, Archives of internal medicine.

[213]  R. Hurt,et al.  Effects of transdermal nicotine treatment on structure and function of coronary artery bypass grafts. , 2000, Journal of applied physiology.

[214]  D. Hatsukami,et al.  Effects of Transdermal Nicotine or Smoking on Nicotine Concentrations and Maternal‐Fetal Hemodynamics , 1997, Obstetrics and gynecology.

[215]  A. H. Ritchie,et al.  Bupropion-Induced Serum Sickness–Like Reaction , 2000, The Annals of pharmacotherapy.

[216]  T. Baker,et al.  Measures of affect and nicotine dependence predict differential response to smoking cessation treatments. , 1992, Journal of consulting and clinical psychology.

[217]  N. Heather,et al.  General Practitioner Interventions for Smoking Cessation: Past Results and Future Prospects , 1990, Behaviour Change.

[218]  Joi Odishaw,et al.  Effects of Steady‐State Bupropion on the Pharmacokinetics of Lamotrigine in Healthy Subjects , 2000, Pharmacotherapy.

[219]  V. Hasselblad,et al.  Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research. , 1997, JAMA.

[220]  J. McClure,et al.  Smoking cessation: recent developments in behavioral and pharmacologic interventions. , 1998, Oncology.

[221]  P. McGovern,et al.  An assessment of nicotine gum as an adjunct to freedom from smoking cessation clinics. , 1992, Addictive behaviors.

[222]  K. Fagerström.  Effects of nicotine chewing gum and follow-up appointments in physician-based smoking cessation. , 1984, Preventive medicine.

[223]  R. Ramasubbu.  Bupropion treatment-related sexual side effects: a case report. , 2000, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[224]  J. Feighner,et al.  A double-blind study of bupropion and placebo in depression. , 1984, The American journal of psychiatry.

[225]  J. Hirsch,et al.  The long-term effect of nicotine on the oral mucosa. , 1999, Addiction.

[226]  A. Hjalmarson.  Effect of nicotine chewing gum in smoking cessation. A randomized, placebo-controlled, double-blind study. , 1984, JAMA.

[227]  R. Doll,et al.  Mortality in relation to smoking: 20 years' observations on male British doctors. , 1976, British medical journal.

[228]  R. Richmond,et al.  The transdermal nicotine patch: results of a randomised placebo‐controlled trial , 1994, The Medical journal of Australia.

[229]  C. Patten,et al.  Development of depression during placebo-controlled trials of bupropion for smoking cessation: case reports. , 1999, Journal of Clinical Psychiatry.

[230]  T. Kosten,et al.  Pharmacotherapy for opioid and cocaine abuse. , 1997, The Medical clinics of North America.

[231]  P. Tønnesen,et al.  [A double-blind trial of nicotine patches in smoking cessation]. , 1992, Ugeskrift for laeger.

[232]  L. Grothaus,et al.  Use and cost effectiveness of smoking-cessation services under four insurance plans in a health maintenance organization. , 1998, The New England journal of medicine.

[233]  John P. Feighner,et al.  The use of bupropion in hospitalized depressed patients. , 1983, The Journal of clinical psychiatry.

[234]  J. Cohn,et al.  Comparison of the effects of bupropion and amitriptyline on cardiac conduction in depressed patients. , 1983, The Journal of clinical psychiatry.

[235]  D. Kalman.  Smoking cessation treatment for substance misusers in early recovery: a review of the literature and recommendations for practice. , 1998, Substance use & misuse.

[236]  J. Sarko.  Antidepressants, old and new. A review of their adverse effects and toxicity in overdose. , 2000, Emergency medicine clinics of North America.

[237]  S. Hall,et al.  Nicotine polacrilex: clinic-based strategies with chronically ill smokers. , 1988, Journal of psychoactive drugs.

[238]  S. Fortmann,et al.  Nicotine gum and self-help behavioral treatment for smoking relapse prevention: results from a trial using population-based recruitment. , 1995, Journal of consulting and clinical psychology.

[239]  S. Adnot.  [Tobacco: an atherogenic, thrombogenic or spasmogenic factor?]. , 1998, Archives des maladies du coeur et des vaisseaux.

[240]  P. Stein,et al.  Effect of 21 mg transdermal nicotine patches and smoking cessation on heart rate variability. , 1996, The American journal of cardiology.

[241]  P. Tønnesen,et al.  Two and four mg nicotine chewing gum and group counselling in smoking cessation: an open, randomized, controlled trial with a 22 month follow-up. , 1988, Addictive behaviors.

[242]  B. Walsh,et al.  Cardiovascular effects of bupropion in depressed patients with heart disease. , 1991, The American journal of psychiatry.

[243]  K. Wisborg,et al.  Nicotine Patches for Pregnant Smokers: A Randomized Controlled Study , 2000, Obstetrics and gynecology.

[244]  R. Wolf,et al.  Adverse skin reactions to the nicotine transdermal system. , 1998, Clinics in dermatology.

[245]  L. Fabre,et al.  A multicenter evaluation of bupropion versus placebo in hospitalized depressed patients. , 1983, The Journal of clinical psychiatry.

[246]  M. Fiore,et al.  Achieving Smoking Cessation in Nicotine-Dependent Individuals , 1997 .

[247]  C. Zlotnick,et al.  Comparison of fluoxetine, bupropion, and placebo in the treatment of premenstrual dysphoric disorder. , 1997, Journal of clinical psychopharmacology.

[248]  J. Feighner,et al.  A 102-center prospective study of seizure in association with bupropion. , 1991, The Journal of clinical psychiatry.

[249]  K. Fagerström,et al.  Diagnosis and treatment of nicotine dependence with emphasis on nicotine replacement therapy. A status report. , 2000, European heart journal.

[250]  G. Gustavsson,et al.  Dose effects and predictors of outcome in a randomized trial of transdermal nicotine patches in general practice. , 1995, Addiction.

[251]  I. Campbell,et al.  Transdermal nicotine plus support in patients attending hospital with smoking-related diseases: a placebo-controlled study. , 1996, Respiratory Medicine.

[252]  P. Anderson,et al.  Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial , 2001, The Lancet.

[253]  W. Jordan.  Clinical evaluation of the contact sensitization potential of a transdermal nicotine system (Nicoderm) , 1992, The Journal of family practice.

[254]  H. Maibach,et al.  The local side effects of transdermally absorbed nicotine. , 1992, Skin Pharmacology.

[255]  N. Benowitz.  Nicotine and coronary heart disease. , 1991, Trends in cardiovascular medicine.

[256]  E. A. Gardner.  Effects of bupropion on weight in patients intolerant to previous antidepressants , 1984 .

[257]  D. Hatsukami,et al.  Effects of treatment on cardiovascular risk among smokeless tobacco users. , 1995, Preventive medicine.

[258]  Jordan Wp.  Clinical evaluation of the contact sensitization potential of a transdermal nicotine system (Nicoderm) , 1992 .

[259]  P. Stewart,et al.  Chronic nicotine ingestion and atrial fibrillation. , 1985, British heart journal.

[260]  S. Greenland,et al.  A Meta-Analysis to Assess the Incidence of Adverse Effects Associated with the Transdermal Nicotine Patch , 1998, Drug safety.

[261]  R. Findling,et al.  Antidepressant treatment during breast-feeding. , 1996, The American journal of psychiatry.

[262]  M. Drummond,et al.  Health Care Technology: Effectiveness, Efficiency and Public Policy@@@Methods for the Economic Evaluation of Health Care Programmes , 1988 .

[263]  K. Perkins.  Smoking Cessation in Women , 2001, CNS drugs.

[264]  M. Jarvik,et al.  Efficacy of a nicotine nasal spray in smoking cessation: a placebo-controlled, double-blind trial. , 1995, Addiction.

[265]  E. Settle.  Tinnitus related to bupropion treatment. , 1991, The Journal of clinical psychiatry.

[266]  E D Levin,et al.  Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD). , 1996, Psychopharmacology bulletin.

[267]  J. Biederman,et al.  Bupropion exacerbates tics in children with attention-deficit hyperactivity disorder and Tourette's syndrome. , 1993, Journal of the American Academy of Child and Adolescent Psychiatry.

[268]  J W Dailey,et al.  Antidepressants and seizures: clinical anecdotes overshadow neuroscience. , 1996, Biochemical pharmacology.

[269]  Darrell R. Schroeder,et al.  A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation , 1997 .

[270]  C. Utman,et al.  Long-term effects of nicotine gum on weight gain after smoking cessation. , 1999, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[271]  V. Strecher.  Computer-tailored smoking cessation materials: a review and discussion. , 1999, Patient education and counseling.

[272]  K. Looper,et al.  Precision and comparability of adverse event rates of newer antidepressants. , 1999, Journal of clinical psychopharmacology.

[273]  Patricia Dolan Mullen,et al.  Treating tobacco use and dependence: clinical practice guideline , 2000 .

[274]  H. Manji,et al.  Comparative Tolerability Profiles of the Newer versus Older Antidepressants , 1994, Drug safety.

[275]  C. Silagy,et al.  A systematic review of the effectiveness of promoting lifestyle change in general practice. , 1997, Family practice.

[276]  D. Abrams,et al.  Cue exposure treatment for smoking relapse prevention: a controlled clinical trial. , 1999, Addiction.

[277]  R. Perng,et al.  Randomized, double-blind, placebo-controlled study of transdermal nicotine patch for smoking cessation. , 1998, Journal of the Formosan Medical Association = Taiwan yi zhi.

[278]  D. Ziedonis,et al.  Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. , 2000, The American journal of psychiatry.

[279]  D. Abrams,et al.  Matching High-Dependence and Low-Dependence Smokers to Self-Help Treatment with or Without Nicotine Replacement , 1994 .

[280]  P. Puska,et al.  Nicotine-containing chewing gum in smoking cessation: a double blind trial with half year follow-up. , 1979, Addictive behaviors.

[281]  I. Campbell,et al.  Stopping smoking. Do nicotine chewing-gum and postal encouragement add to doctors' advice. , 1987, The Practitioner.

[282]  Michael C. Fiore,et al.  A Clinical Practice Guideline for Treating Tobacco Use and Dependence A US Public Health Service Report , 2000 .

[283]  M. Kornitzer,et al.  A double blind study of 2 mg versus 4 mg nicotine-gum in an industrial setting. , 1987, Journal of psychosomatic research.

[284]  J. Ottervanger,et al.  Acute myocardial infarction while using the nicotine patch. , 1995, Chest.

[285]  T. Abelin,et al.  CONTROLLED TRIAL OF TRANSDERMAL NICOTINE PATCH IN TOBACCO WITHDRAWAL , 1989, The Lancet.

[286]  R. Becker,et al.  Safety and efficacy of bupropion, a novel antidepressant , 1985 .

[287]  C. Patten.  A Critical Evaluation of Nicotine Replacement Therapy for Teenage Smokers , 2000, Nicotine Addiction Among Adolescents.

[288]  C. S. Frieden,et al.  Prevalence of psychosis, delusions, and hallucinations in clinical trials with bupropion. , 1986, The American journal of psychiatry.

[289]  S. Kadakia,et al.  Acute Effect of Nicotine Patch on Gastric Emptying of Liquid and Solid Contents in Healthy Subjects , 1999, Digestive Diseases and Sciences.

[290]  R. Hurt,et al.  Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. , 1994, JAMA.

[291]  R. Goldberg,et al.  The physician-delivered smoking intervention project: can short-term interventions produce long-term effects for a general outpatient population? , 1994, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[292]  R G Newcombe,et al.  Transdermal nicotine for active ulcerative colitis. , 1994, The New England journal of medicine.

[293]  D. Sheehan,et al.  A case of bupropion-induced seizure. , 1986, The Journal of nervous and mental disease.

[294]  G. Buchkremer,et al.  [Long-term effects of a combination of transdermal nicotine administration with behavior therapy for smoking cessation]. , 1988, Der Nervenarzt.

[295]  P. Whiteman,et al.  Bupropion fails to affect plasma prolactin and growth hormone in normal subjects. , 1982, British journal of clinical pharmacology.

[296]  N. Benowitz,et al.  Non-Nicotine Pharmacotherapy for Smoking Cessation , 2000 .

[297]  N. Wald,et al.  Placebo controlled trial of nicotine chewing gum in general practice. , 1984, British medical journal.

[298]  S. Preskorn,et al.  Evaluation of Bupropion Hydrochloride: The First of a New Class of Atypical Antidepressants , 1984, Pharmacotherapy.

[299]  F. Lebargy,et al.  Nicotine patches and vascular risks , 1993, The Lancet.

[300]  C. Godfrey,et al.  Development of the health and economic consequences of smoking interactive model , 2001, Tobacco control.

[301]  F. Song,et al.  Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability. , 1993, BMJ.

[302]  N. G. Popovich,et al.  Smoking cessation: Part 2--Pharmacologic approaches. , 1998, Journal of the American Pharmaceutical Association.

[303]  N. Dousset,et al.  HYPERCHOLESTEROLAEMIA AFTER ADMINISTRATION OF NICOTINE CHEWING GUM , 1986, The Lancet.

[304]  M. Fiore,et al.  Comparative Efficacy and Tolerability of Nicotine Replacement Therapies , 1995 .

[305]  J. Ahluwalia,et al.  The cost-effectiveness of the nicotine transdermal patch for smoking cessation. , 1997, Preventive medicine.

[306]  K. Haustein.  Pharmacotherapy of nicotine dependence. , 2000, International journal of clinical pharmacology and therapeutics.

[307]  M. Raw,et al.  Comparison of nicotine chewing-gum and psychological treatments for dependent smokers. , 1980, British medical journal.

[308]  Winter Fd,et al.  Smoking cessation: a clinical study of the transdermal nicotine patch. , 1995 .

[309]  J. Biederman,et al.  Case Study: Bupropion Exacerbates Tics in Children with Attention-deficit Hyperactivity Disorder and Tourette's Syndrome , 1993 .

[310]  M. Jarvik,et al.  Transdermal nicotine reduces cigarette craving and nicotine preference , 1985, Clinical pharmacology and therapeutics.

[311]  E. A. Gardner.  Long-term preventive care in depression: the use of bupropion in patients intolerant of other antidepressants. , 1983, The Journal of clinical psychiatry.

[312]  R. Dahl,et al.  The effect of nicotine, silver acetate, and placebo chewing gum on the cessation of smoking. The influence of smoking type and nicotine dependence. , 1991, The International journal of the addictions.

[313]  P. Tønnesen,et al.  Recycling with nicotine patches in smoking cessation. , 1993, Addiction.

[314]  I. Liberzon,et al.  Bupropion and delirium. , 1990, The American journal of psychiatry.

[315]  P. Tønnesen,et al.  Recycling of hard-core smokers with nicotine nasal spray. , 1996, The European respiratory journal.

[316]  S S Smith,et al.  Predicting smoking cessation. Who will quit with and without the nicotine patch. , 1994, JAMA.

[317]  E. A. Gardner,et al.  Bupropion—An Antidepressant Without Sexual Pathophysiological Action , 1985, Journal of clinical psychopharmacology.

[318]  C. Fichtner,et al.  Bupropion-associated mania in a patient with HIV infection. , 1992, Journal of Clinical Psychopharmacology.

[319]  R. Hurt,et al.  Residential (inpatient) treatment compared with outpatient treatment for nicotine dependence. , 2001, Mayo Clinic proceedings.

[320]  K. Harris,et al.  Pharmacotherapy of smoking cessation. , 2000, Archives of family medicine.

[321]  K. Schuh,et al.  Nicotine nasal spray and vapor inhaler: abuse liability assessment , 1997, Psychopharmacology.

[322]  Å. Westin,et al.  A double-blind randomized trial of nicotine nasal spray as an aid in smoking cessation. , 1997, The European respiratory journal.

[323]  M. Jarvik,et al.  Degree of addiction and effectiveness of nicotine gum therapy for smoking. , 1984, The American journal of psychiatry.

[324]  B. Keller-Stanislawski,et al.  Transdermal nicotine in smoking cessation and involvement of non-specific influences. , 1993, International journal of clinical pharmacology, therapy, and toxicology.

[325]  J. Addington,et al.  Group treatment for smoking cessation among persons with schizophrenia. , 1998, Psychiatric services.

[326]  R. Weisler,et al.  Comparison of bupropion and trazodone for the treatment of major depression. , 1994, Journal of clinical psychopharmacology.

[327]  J. Devane,et al.  Clinical and pharmacokinetic properties of a transdermal nicotine patch , 1990, Clinical pharmacology and therapeutics.

[328]  C M Anderson,et al.  Telephone counseling as adjuvant treatment for nicotine replacement therapy in a "real-world" setting. , 2000, Preventive medicine.

[329]  K. Overvad,et al.  Nicotine patches in smoking cessation: a randomized trial among over-the-counter customers in Denmark. , 1997, American journal of epidemiology.

[330]  P. Tønnesen,et al.  Effect of nicotine chewing gum in combination with group counseling on the cessation of smoking. , 1988, The New England journal of medicine.

[331]  G. Färm.  Contact allergy to nicotine from a nicotine patch , 1993, Contact dermatitis.

[332]  Nicotine patches improve mood and response speed in a lexical decision task. , 2000, Addictive behaviors.

[333]  J. Davidson,et al.  Seizures and bupropion: a review. , 1989, The Journal of clinical psychiatry.

[334]  G. Sivyer,et al.  Smoking Cessation Study Involving a Transdermal Nicotine Patch , 1994 .

[335]  S. Rennard,et al.  Effect of transdermal nicotine delivery as an adjunct to low-intervention smoking cessation therapy. A randomized, placebo-controlled, double-blind study. , 1991, Archives of internal medicine.

[336]  J. Rose,et al.  Airway sensory replacement combined with nicotine replacement for smoking cessation. A randomized, placebo-controlled trial using a citric acid inhaler. , 1995, Chest.

[337]  Effectiveness of a 24-hour nicotine patch in conjunction with a cognitive behavioural programme: one year outcome transdermal , 1997 .

[338]  I. Campbell,et al.  Smoking cessation in hospital patients given repeated advice plus nicotine or placebo chewing gum. , 1991, Respiratory medicine.

[339]  M. Goldstein.  Bupropion sustained release and smoking cessation. , 1998, The Journal of clinical psychiatry.

[340]  J. Pierce.  Stroke following Application of a Nicotine Patch , 1994, The Annals of pharmacotherapy.

[341]  Tammy O. Tengs,et al.  Five-hundred life-saving interventions and their cost-effectiveness. , 1995, Risk analysis : an official publication of the Society for Risk Analysis.

[342]  J. Hughes.  Transdermal nicotine: clarifications, side effects, and funding. , 1993, JAMA.

[343]  J. Hughes,et al.  Nicotine vs placebo gum in general medical practice. , 1989, JAMA.

[344]  P. Vokonas,et al.  Effects of nicotine gum dose by level of nicotine dependence. , 2000, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[345]  D. Quinton,et al.  Unit Costs of Health and Social Care 2004 , 2004 .

[346]  Aker,et al.  A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. , 1999, The New England journal of medicine.

[347]  R. Young,et al.  Mania in an elderly man treated with bupropion. , 1991, The American journal of psychiatry.

[348]  B. J. Sudan.  Comment: Niacin, Nicotine, and Flushing , 1994, The Annals of pharmacotherapy.

[349]  R. Balon.  Bupropion and nightmares. , 1996, The American journal of psychiatry.

[350]  N. Benowitz.  Toxicity of nicotine: implications with regard to nicotine replacement therapy. , 1988, Progress in clinical and biological research.

[351]  C. Ananth,et al.  Transdermal nicotine replacement in pregnancy: maternal pharmacokinetics and fetal effects. , 1997, American journal of obstetrics and gynecology.

[352]  W. E. Fann,et al.  Bupropion in depression: a tri-center placebo-controlled study. , 1983, The Journal of clinical psychiatry.

[353]  A. Nitenberg,et al.  Effects of nicotine gum on coronary vasomotor responses during sympathetic stimulation in patients with coronary artery stenosis. , 1999, Journal of cardiovascular pharmacology.

[354]  P. Peloso,et al.  Serum sickness-like reaction with bupropion. , 1999, JAMA.

[355]  Young Rc,et al.  Mania in an elderly man treated with bupropion. , 1991 .

[356]  R. Battista,et al.  A randomized trial of smoking cessation interventions in general practice in Italy , 1991, Cancer Causes & Control.

[357]  D B Abrams,et al.  Effects of behavioral skills training and schedule of nicotine gum administration on smoking cessation. , 1989, The American journal of psychiatry.

[358]  D. Hatsukami,et al.  Treatment of spit tobacco users with transdermal nicotine system and mint snuff. , 2000, Journal of consulting and clinical psychology.

[359]  M. Jarvik,et al.  Cardiovascular effects of nicotine gum and cigarettes assessed by ECG and echocardiography. , 1985, NIDA research monograph.

[360]  Dan Tzivoni,et al.  Cardiovascular Safety of Transdermal Nicotine Patches in Patients with Coronary Artery Disease who Try to Quit Smoking , 1998, Cardiovascular Drugs and Therapy.

[361]  R. West,et al.  A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler , 2000, Psychopharmacology.

[362]  N. Rojansky,et al.  Menstrual irregularities associated with bupropion treatment. , 1991, The Journal of clinical psychiatry.

[363]  J. Bigger,et al.  Cardiovascular effects of imipramine and bupropion in depressed patients with congestive heart failure. , 1987, Journal of clinical psychopharmacology.

[364]  K. Sinusas,et al.  Smokeless tobacco cessation: report of a preliminary trial using nicotine chewing gum. , 1993, The Journal of family practice.

[365]  D. H. Schroeder,et al.  Excretion of Bupropion in Breast Milk , 1993, The Annals of pharmacotherapy.

[366]  A. Prochazka,et al.  A Comparison of Nicotine Delivery Systems in a Multimodality Smoking Cessation Program , 1996, The Nurse practitioner.

[367]  C. Patten,et al.  Cost-effectiveness of treating nicotine dependence: the Mayo Clinic experience. , 1997, Mayo Clinic proceedings.

[368]  O. Wiklund,et al.  The nicotine inhaler in smoking cessation. , 1997, Archives of internal medicine.

[369]  J. Modell,et al.  Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline , 1997, Clinical pharmacology and therapeutics.

[370]  A. Stoll,et al.  Antidepressant-associated mania: a controlled comparison with spontaneous mania. , 1994, The American journal of psychiatry.

[371]  S. Mohiuddin,et al.  Comparison of Fixed‐Dose Transdermal Nicotine, Tapered‐Dose Transdermal Nicotine, and Buspirone in Smoking Cessation , 1994, Journal of clinical pharmacology.

[372]  Walsh Ra,et al.  Effects of maternal smoking on adverse pregnancy outcomes: examination of the criteria of causation. , 1994 .

[373]  Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy. , 1998 .

[374]  H. P. Lee,et al.  Nicotine-replacement products in smoking cessation: a review. , 1993, Singapore medical journal.

[375]  Nelson Jc,et al.  Seizures associated with antidepressants: a review. , 1993, The Journal of clinical psychiatry.

[376]  A. Garvey,et al.  Nicotine gum dose and weight gain after smoking cessation. , 1996, Journal of consulting and clinical psychology.

[377]  C. Lineberry,et al.  Safety and efficacy of bupropion and nortriptyline in outpatients with depression , 1994 .

[378]  A. Alao,et al.  Serum Sickness Induced by Bupropion , 1999, The Annals of pharmacotherapy.

[379]  P. Tønnesen,et al.  Smoking cessation with four nicotine replacement regimes in a lung clinic. , 2000, The European respiratory journal.

[380]  R Doll,et al.  Mortality in relation to smoking: 40 years' observations on male British doctors , 1994, BMJ.

[381]  S S Smith,et al.  Varying nicotine patch dose and type of smoking cessation counseling. , 1995, JAMA.

[382]  G. Bootsma,et al.  Smoking cessation: which aids are worthwhile? , 2000, The Netherlands journal of medicine.

[383]  E. Andrews,et al.  The Pregnancy Registry program at Glaxo Wellcome Company. , 1999, The Journal of allergy and clinical immunology.

[384]  D. Taylor,et al.  Smoking cessation in primary care. A randomized controlled trial of nicotine-bearing chewing gum. , 1989, The Journal of family practice.

[385]  J. Beckham,et al.  A Preliminary Study of Bupropion Sustained-Release for Smoking Cessation in Patients With Chronic Posttraumatic Stress Disorder , 2001, Journal of clinical psychopharmacology.

[386]  M. Jarvis,et al.  Randomised controlled trial of nasal nicotine spray in smoking cessation , 1992, The Lancet.

[387]  W. Bailey,et al.  Safety of nicotine polacrilex gum used by 3,094 participants in the Lung Health Study. Lung Health Study Research Group. , 1996, Chest.

[388]  K. Perkins,et al.  Low-dose nicotine nasal spray use and effects during initial smoking cessation. , 1996 .

[389]  D. Short,et al.  Bupropion-induced carbohydrate craving and weight gain. , 1992, The American journal of psychiatry.

[390]  Brown Wa,et al.  Single-dose fluoxetine in management of premenstrual syndrome. , 1992 .

[391]  J. Zajecka.  Strategies for the treatment of antidepressant-related sexual dysfunction. , 2001, The Journal of clinical psychiatry.

[392]  S. Sussman,et al.  Developing Treatment for Tobacco Addicted Youth–Issues and Challenges , 2000 .

[393]  Faguet Ra,et al.  Overview of clinically significant adverse reactions to bupropion. , 1983 .

[394]  J. Cañive,et al.  Bupropion treatment in veterans with posttraumatic stress disorder: an open study. , 1998, Journal of clinical psychopharmacology.

[395]  J. Harackiewicz,et al.  Nicotine gum and self-help manuals in smoking cessation: an evaluation in a medical context. , 1988, Addictive behaviors.

[396]  S. Stahl,et al.  Safety profile of sustained-release bupropion in depression: results of three clinical trials. , 1999, Clinical therapeutics.

[397]  M. Fiore,et al.  Cost-benefit analysis of sustained-release bupropion, nicotine patch, or both for smoking cessation. , 2000, Preventive medicine.

[398]  S. Sutton,et al.  Smoking intervention in the workplace using videotapes and nicotine chewing gum. , 1988, Preventive medicine.

[399]  J. Wilkins,et al.  A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients. , 1995, Drug and alcohol dependence.

[400]  H. Howald,et al.  [Weaning of young smokers using a transdermal nicotine patch]. , 1991, Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.

[401]  M. Malesker,et al.  Eosinophilia Associated with Bupropion , 1995, The Annals of pharmacotherapy.

[402]  P. Tønnesen,et al.  Nicotine Replacement Therapy in Patients with Coronary Heart Disease , 1999 .

[403]  J. McNeil,et al.  Predictors and Timing of Adverse Experiences During Transdermal Nicotine Therapy , 1999, Drug safety.

[404]  R. Colligan,et al.  Nicotine patch therapy in adolescent smokers. , 1996, Pediatrics.

[405]  W. E. Tucker.  Preclinical toxicology of bupropion: an overview. , 1983, The Journal of clinical psychiatry.

[406]  M. Stitzer,et al.  Dose effects of nicotine gum. , 1995, Addictive behaviors.

[407]  E. Levin,et al.  Nicotine skin patch treatment increases abstinence, decreases withdrawal symptoms, and attenuates rewarding effects of smoking. , 1994, Journal of clinical psychopharmacology.

[408]  M. Bende,et al.  Evaluation of side effects after nicotine nasal spray in patients with chronic rhinitis. , 1998, Rhinology.

[409]  S. Hall,et al.  Mood management and nicotine gum in smoking treatment: a therapeutic contact and placebo-controlled study. , 1996, Journal of consulting and clinical psychology.

[410]  L. Stead,et al.  Effectiveness of interventions to help people stop smoking: findings from the Cochrane Library , 2000, BMJ : British Medical Journal.

[411]  A. Gulsvik,et al.  Higher dosage nicotine patches increase one-year smoking cessation rates: results from the European CEASE trial. Collaborative European Anti-Smoking Evaluation. European Respiratory Society. , 1999, The European respiratory journal.

[412]  S. Zisook,et al.  A prospective safety surveillance study for bupropion sustained-release in the treatment of depression. , 1998, The Journal of clinical psychiatry.

[413]  S. Hall,et al.  Nicotine gum and behavioral treatment: a placebo controlled trial. , 1987, Journal of consulting and clinical psychology.

[414]  T. SalvadorLlivina,et al.  [Treatment of smoking: efficacy of the use of nicotine chewing gum. Double-blind study]. , 1988 .

[415]  Warren C. Stern,et al.  Use of bupropion in patients who exhibit orthostatic hypotension on tricyclic antidepressants. , 1983, The Journal of clinical psychiatry.

[416]  Troy M. Smith,et al.  Smoking cessation: A clinical study of the transdermal nicotine patch , 1995, The Journal of the American Osteopathic Association.

[417]  G. Gustavsson,et al.  Combined use of nicotine patch and gum in smoking cessation: a placebo-controlled clinical trial. , 1995, Preventive medicine.

[418]  H. Manji,et al.  Bupropion, ECT, and dopaminergic overdrive. , 1991, The American journal of psychiatry.

[419]  R. West,et al.  Double-blind placebo controlled trial of dextrose tablets and nicotine patch in smoking cessation , 1998, Psychopharmacology.

[420]  G. Kochak,et al.  Pharmacokinetic Disposition of Multiple-Dose Transdermal Nicotine in Healthy Adult Smokers , 1992, Pharmaceutical Research.

[421]  S Shiffman,et al.  Comparative efficacy of 24-hour and 16-hour transdermal nicotine patches for relief of morning craving. , 2000, Addiction.