Title : Single-molecule sequencing reveals complex genomic variation of hepatitis 1 B virus during 15 years of chronic infection following liver transplantation . 2 Running title : Single-molecule analysis reveals complex HBV

[1]  Sudhir Kumar,et al.  MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. , 2016, Molecular biology and evolution.

[2]  A. Kramvis.  Genotypes and Genetic Variability of Hepatitis B Virus , 2014, Intervirology.

[3]  B. Hall,et al.  Building phylogenetic trees from molecular data with MEGA. , 2013, Molecular biology and evolution.

[4]  A. Wilm,et al.  LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets , 2012, Nucleic acids research.

[5]  David S. Campo,et al.  Convergence and coevolution of Hepatitis B virus drug resistance , 2012, Nature Communications.

[6]  Y. Ni,et al.  The Pre-S2 Domain of the Hepatitis B Virus Is Dispensable for Infectivity but Serves a Spacer Function for L-Protein-Connected Virus Assembly , 2010, Journal of Virology.

[7]  B. McMahon,et al.  The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B , 2009, Hepatology international.

[8]  Y. Wen,et al.  A double‐spliced defective hepatitis B virus genome derived from hepatocellular carcinoma tissue enhanced replication of full‐length virus , 2009, Journal of medical virology.

[9]  M. Choi,et al.  Clinical significance of pre‐S mutations in patients with genotype C hepatitis B virus infection , 2007, Journal of viral hepatitis.

[10]  P. Angus,et al.  Clinical Emergence of Entecavir-Resistant Hepatitis B Virus Requires Additional Substitutions in Virus Already Resistant to Lamivudine , 2004, Antimicrobial Agents and Chemotherapy.

[11]  A. V. Smirnov,et al.  High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity , 2003, Journal of Clinical Microbiology.

[12]  Y. Shiratori,et al.  YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitrofull‐length viral DNA transfection , 1999, Hepatology.

[13]  Ding‐Shinn Chen,et al.  Hepatitis B Virus Infection , 2007 .

[14]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[15]  S. Locarnini,et al.  HBV genotyping and analysis for unique mutations. , 2004, Methods in molecular medicine.