Evaluation of novel algorithm embedded in a wearable sEMG device for seizure detection

We implemented a modified version of a previously published algorithm for detection of generalized tonic-clonic seizures into a prototype wireless surface electromyography (sEMG) recording device. The method was modified to require minimum computational load, and two parameters were trained on prior sEMG data recorded with the device. Along with the normal sEMG recording, the device is able to set an alarm whenever the implemented algorithm detects a seizure. These alarms are annotated in the data file along with the signal. The device was tested at the Epilepsy Monitoring Unit (EMU) at the Danish Epilepsy Center. Five patients were included in the study and two of them had generalized tonic-clonic seizures. All patients were monitored for 2-5 days. A double-blind study was made on the five patients. The overall result showed that the device detected four of seven seizures and had a false detection rate of 0.003/h or one in twelve days.

[1]  Josemir W Sander,et al.  Do antiepileptic drugs or generalized tonic–clonic seizure frequency increase SUDEP risk? A combined analysis , 2012, Epilepsia.

[2]  Poul Jennum,et al.  The social and economic consequences of epilepsy: A controlled national study , 2011, Epilepsia.

[3]  Sándor Beniczky,et al.  Automatic multi-modal intelligent seizure acquisition (MISA) system for detection of motor seizures from electromyographic data and motion data , 2012, Comput. Methods Programs Biomed..

[4]  D. Hesdorffer,et al.  Sudden Unexpected Death in Epilepsy , 2013, CNS Drugs.

[5]  K. Meador,et al.  Epilepsy , 2011, Neurology.

[6]  Carlos E. M. Tassinari,et al.  Glossary of Descriptive Terminology for Ictal Semiology: Report of the ILAE Task Force on Classification and Terminology , 2001, Epilepsia.

[7]  C. Elger,et al.  Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) , 2005, Epilepsia.

[8]  Robert S. Fisher,et al.  Detection of seizure-like movements using a wrist accelerometer , 2011, Epilepsy & Behavior.

[9]  W. Hauser,et al.  Comment on Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) , 2005, Epilepsia.

[10]  Isa Conradsen,et al.  Seizure onset detection based on a Uni- or Multi-modal Intelligent Seizure Acquisition (UISA/MISA) system , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[11]  Helge B. D. Sørensen,et al.  Automated Algorithm for Generalized Tonic–Clonic Epileptic Seizure Onset Detection Based on sEMG Zero-Crossing Rate , 2012, IEEE Transactions on Biomedical Engineering.

[12]  Sándor Beniczky,et al.  Patterns of muscle activation during generalized tonic and tonic–clonic epileptic seizures , 2011, Epilepsia.

[13]  J. French,et al.  Refractory Epilepsy: One Size Does Not Fit All , 2006, Epilepsy currents.

[14]  Bart Vanrumste,et al.  Detection of nocturnal frontal lobe seizures in pediatric patients by means of accelerometers: A first study , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[15]  Svetlana Kipervasser,et al.  A Novel Portable Seizure Detection Alarm System: Preliminary Results , 2011, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[16]  Josemir W Sander,et al.  Combined analysis of risk factors for SUDEP , 2011, Epilepsia.