Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation

Exhaled nitric oxide (FeNO) associates with asthma and eosinophilic inflammation. However, relationships between nitric oxide synthases, arginase, FeNO, asthma severity and inflammation remain poorly understood.

[1]  Dean P. Jones,et al.  Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2. , 2011, The Journal of allergy and clinical immunology.

[2]  W. Busse,et al.  Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. , 2010, American journal of respiratory and critical care medicine.

[3]  P. Marsden,et al.  Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[4]  Fernando Holguin,et al.  Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. , 2009, The Journal of allergy and clinical immunology.

[5]  S. Wenzel,et al.  IL‐13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[6]  H. Meurs,et al.  Arginine homeostasis in allergic asthma. , 2008, European journal of pharmacology.

[7]  S. Keslacy,et al.  Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1. , 2008, American journal of respiratory cell and molecular biology.

[8]  I. Pavord,et al.  Increased sputum and bronchial biopsy IL-13 expression in severe asthma. , 2008, The Journal of allergy and clinical immunology.

[9]  M. Ichinose,et al.  Nitrative stress in refractory asthma. , 2008, The Journal of allergy and clinical immunology.

[10]  S. Wenzel,et al.  Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies , 2007, The Lancet.

[11]  A. Boner,et al.  Formoterol, montelukast, and budesonide in asthmatic children: effect on lung function and exhaled nitric oxide. , 2007, Respiratory medicine.

[12]  V. Suresh,et al.  Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. , 2007, American journal of respiratory cell and molecular biology.

[13]  A. Nicholson,et al.  Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests. , 2006, American journal of respiratory and critical care medicine.

[14]  S. Wenzel,et al.  Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13. , 2006, The Journal of allergy and clinical immunology.

[15]  M. Rothenberg,et al.  The arginine-arginase balance in asthma and lung inflammation. , 2006, European journal of pharmacology.

[16]  S. Wenzel,et al.  Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma. , 2005, The Journal of allergy and clinical immunology.

[17]  I. Pavord,et al.  The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[18]  S. Hazen,et al.  Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. , 2005, The American journal of pathology.

[19]  M. Rothenberg,et al.  Arginine in asthma and lung inflammation. , 2004, The Journal of nutrition.

[20]  J. Vockley,et al.  The human arginases and arginase deficiency , 1998, Journal of Inherited Metabolic Disease.

[21]  H. Meurs,et al.  Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. , 2003, Trends in pharmacological sciences.

[22]  H. Hoogsteden,et al.  Airway inflammation is present during clinical remission of atopic asthma. , 2001, American journal of respiratory and critical care medicine.

[23]  P. Shah,et al.  Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis. , 2001, The European respiratory journal.

[24]  E. Israel,et al.  Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. , 2001, American journal of respiratory and critical care medicine.

[25]  S. Hazen,et al.  Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species4 , 2001, The Journal of Immunology.

[26]  Arthur S Slutsky,et al.  Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. , 2001, Chest.

[27]  P. Howarth,et al.  Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. , 2001, Thorax.

[28]  J. Pfeilschifter,et al.  Glucocorticoids inhibit lipopolysaccharide‐induced up‐regulation of arginase in rat alveolar macrophages , 2001, British journal of pharmacology.

[29]  M. Biraghi,et al.  Time-Dependent Changes in Orally Exhaled Nitric Oxide and Pulmonary Functions Induced by Inhaled Cortico-steroids in Childhood Asthma , 2001, The Journal of asthma : official journal of the Association for the Care of Asthma.

[30]  Mary Jane Thomassen,et al.  Regulation of No Synthesis Transcriptional and Post-translational Oxide (no) in Asthma: Evidence for Molecular Mechanisms of Increased Nitric , 2013 .

[31]  S. Spector,et al.  Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. , 2000, American journal of respiratory and critical care medicine.

[32]  G. Snell,et al.  In stable lung transplant recipients, exhaled nitric oxide levels positively correlate with airway neutrophilia and bronchial epithelial iNOS. , 1999, American journal of respiratory and critical care medicine.

[33]  G. Wu,et al.  Glucocorticoids mediate the enhanced expression of intestinal type II arginase and argininosuccinate lyase in postweaning pigs. , 1999, The Journal of nutrition.

[34]  T. Gotoh,et al.  Expression of arginase II and related enzymes in the rat small intestine and kidney. , 1999, Journal of biochemistry.

[35]  T. Gotoh,et al.  Arginase II Downregulates Nitric Oxide (NO) Production and Prevents NO-mediated Apoptosis in Murine Macrophage-derived RAW 264.7 Cells , 1999, The Journal of cell biology.

[36]  Guoyao Wu,et al.  Arginine metabolism: nitric oxide and beyond. , 1998, The Biochemical journal.

[37]  S. Morris,et al.  Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells. , 1998, American journal of physiology. Endocrinology and metabolism.

[38]  K. Chung,et al.  Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. , 1998, Thorax.

[39]  B. Williams,et al.  Interferon g and Interleukin 4 Stimulate Prolonged Expression of Inducible Nitric Oxide Synthase in Human Airway Epithelium through Synthesis of Soluble Mediators , 1997 .

[40]  J. Zweier,et al.  Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  W. Pryor,et al.  The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. , 1995, The American journal of physiology.

[42]  P. Howarth,et al.  Induction of nitric oxide synthase in asthma , 1993, The Lancet.

[43]  S. Szefler,et al.  Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. , 1993, Journal of immunology.

[44]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.