The pharmacological treatment of epilepsy in adults

[1]  W. Turner,et al.  INTERNATIONAL LEAGUE AGAINST EPILEPSY. , 1913 .

[2]  A. Berg,et al.  The risk of seizure recurrence following a first unprovoked seizure , 1991, Neurology.

[3]  D. Chadwick,et al.  Psychosocial Outcomes of Antiepileptic Drug Discontinuation , 1992 .

[4]  First Seizure.  Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic‐clonic seizure , 1993, Neurology.

[5]  Prognosis.  Guidelines for Epidemiologic Studies on Epilepsy , 1993, Epilepsia.

[6]  D. Chadwick,et al.  Outcomes After Seizure Recurrence in People with Well‐Controlled Epilepsy and the Factors That Influence It , 1996, Epilepsia.

[7]  M. Brodie,et al.  Lamotrigine substitution study: evidence for synergism with sodium valproate? , 1997, Epilepsy Research.

[8]  E. Beghi,et al.  Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy , 1997, Neurology.

[9]  R Kale,et al.  Bringing epilepsy out of the shadows , 1997, BMJ.

[10]  A. Hofman,et al.  Maternal Use of Antiepileptic Drugs and the Risk of Major Congenital Malformations: A Joint European Prospective Study of Human Teratogenesis Associated with Maternal Epilepsy , 1997, Epilepsia.

[11]  D. Berry,et al.  Carbamazepine Toxicity with Lamotrigine: Pharmacokinetic or Pharmacodynamic Interaction? , 1998, Epilepsia.

[12]  E. Perucca.  Pharmacoresistance in Epilepsy , 1998 .

[13]  W. Hauser,et al.  Risk of recurrent seizures after two unprovoked seizures. , 1998, The New England journal of medicine.

[14]  E. Perucca,et al.  The Efficacy of Valproate‐Lamotrigine Comedication in Refractory Complex Partial Seizures: Evidence for a Pharmacodynamic Interaction , 1999, Epilepsia.

[15]  T. Tomson,et al.  Monotherapy trials with the new antiepileptic drugs: study designs, practical relevance and ethical implications , 1999, Epilepsy Research.

[16]  A. Hofman,et al.  Antiepileptic drug regimens and major congenital abnormalities in the offspring , 1999, Annals of neurology.

[17]  M. Brodie,et al.  Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy , 1999, Epilepsy Research.

[18]  G. Avanzini,et al.  Congenital malformations due to antiepileptic drugs , 1999, Epilepsy Research.

[19]  P. Patsalos,et al.  Selection of Antiepileptic Drug Polytherapy Based on Mechanisms of Action: The Evidence Reviewed , 2000, Epilepsia.

[20]  C. Elger,et al.  Oxcarbazepine Placebo‐Controlled, Dose‐Ranging Trial in Refractory Partial Epilepsy , 2000, Epilepsia.

[21]  S. Shorvon,et al.  Assessing risk to benefit ratio in antiepileptic drug therapy , 2000, Epilepsy Research.

[22]  P. Kwan,et al.  Early identification of refractory epilepsy. , 2000, The New England journal of medicine.

[23]  S. Shorvon,et al.  Harnessing the Clinical Potential of Antiepileptic Drug Therapy , 2001, CNS drugs.

[24]  M. Brodie,et al.  Effectiveness of First Antiepileptic Drug , 2001, Epilepsia.

[25]  Josemir W Sander,et al.  A Pharmacoepidemiologic Study of Factors Influencing the Outcome of Treatment with Lamotrigine in Chronic Epilepsy , 2001, Epilepsia.

[26]  S. A. Gromov,et al.  Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial , 2003, Epilepsy Research.

[27]  N. Ebrahimi,et al.  Initial outcomes in the Multicenter Study of Epilepsy Surgery , 2003, Neurology.

[28]  E. Perucca,et al.  Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs , 2003, The Lancet Neurology.

[29]  E. Perucca,et al.  Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs , 2003, The Lancet Neurology.

[30]  Simon Shorvon,et al.  Treatment of Epilepsy , 2004 .

[31]  G. Baker,et al.  Systematic screening allows reduction of adverse antiepileptic drug effects , 2004, Neurology.

[32]  B. Bourgeois,et al.  Efficacy and Tolerability of the New Antiepileptic Drugs, I: Treatment of New‐Onset Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society , 2004, Epilepsia.

[33]  Ettore Beghi,et al.  Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention , 2004, Epilepsy Research.

[34]  D. Chadwick,et al.  The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies. , 2004, Journal of neurology, neurosurgery, and psychiatry.

[35]  E. Perucca,et al.  Revisiting phenobarbital for epilepsy , 2004, BMJ : British Medical Journal.

[36]  I. Valencia,et al.  Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. , 2004, Epileptic disorders : international epilepsy journal with videotape.

[37]  G. Perugi,et al.  Antiepileptic drugs: indications other than epilepsy. , 2004, Epileptic disorders : international epilepsy journal with videotape.

[38]  E. Beghi,et al.  Should Antiepileptic Drugs Be Withdrawn in Seizure-Free Patients? , 2004, CNS drugs.

[39]  B. Källén,et al.  Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation‐wide, population‐based register study , 2004, Acta paediatrica.

[40]  B. Uthman,et al.  New onset geriatric epilepsy , 2005, Neurology.

[41]  W. Löscher,et al.  Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure‐free patients: a review of current clinical experience , 2005, Acta neurologica Scandinavica.

[42]  C. Elger,et al.  Response: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) , 2005 .

[43]  A. Auvinen,et al.  Antiepileptic drug use of women with epilepsy and congenital malformations in offspring , 2005, Neurology.

[44]  L. Holmes,et al.  Increased rate of major malformations in offspring exposed to valproate during pregnancy , 2005, Neurology.

[45]  W. Hauser,et al.  Comment on Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) , 2005, Epilepsia.

[46]  P. Kwan,et al.  Overtreatment in Epilepsy , 2005, CNS drugs.

[47]  A. Marson,et al.  Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial , 2005, The Lancet.

[48]  J. Leach,et al.  Epilepsy in the UK: Misdiagnosis, mistreatment, and undertreatment? The Wrexham area epilepsy project , 2005, Seizure.

[49]  Anthony G Marson,et al.  Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial , 2006, The Lancet Neurology.

[50]  B. Irwin,et al.  Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[51]  Tracy Glauser,et al.  ILAE Treatment Guidelines: Evidence‐based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes , 2006, Epilepsia.

[52]  E. Beghi,et al.  Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy , 2006, Neurology.

[53]  S. Shorvon,et al.  Results of treatment changes in patients with apparently drug‐resistant chronic epilepsy , 2007, Annals of neurology.

[54]  David F. Smith,et al.  The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial , 2007, The Lancet.

[55]  T. Tomson,et al.  Old versus new antiepileptic drugs: the SANAD study , 2007, The Lancet.

[56]  Jing Shen,et al.  The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial , 2007, The Lancet.

[57]  A. Marson,et al.  Quality of life outcomes of immediate or delayed treatment of early epilepsy and single seizures , 2007, Neurology.

[58]  P Ryvlin,et al.  Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy , 2007, Neurology.

[59]  L. Gjerstad,et al.  An International Multicenter Randomized Double‐Blind Controlled Trial of Lamotrigine and Sustained‐Release Carbamazepine in the Treatment of Newly Diagnosed Epilepsy in the Elderly , 2007, Epilepsia.

[60]  A. Schulze-Bonhage,et al.  The influence of antiepileptic drugs on cognition: A comparison of levetiracetam with topiramate , 2007, Epilepsy & Behavior.

[61]  W. Hauser,et al.  Likelihood of seizure remission in an adult population with refractory epilepsy , 2007, Annals of neurology.

[62]  M. Mula,et al.  The Role of Anticonvulsant Drugs in Anxiety Disorders: A Critical Review of the Evidence , 2007, Journal of clinical psychopharmacology.

[63]  M. Eadie,et al.  The Australian Register of Antiepileptic Drugs in Pregnancy: The first 1002 pregnancies , 2007, The Australian & New Zealand journal of obstetrics & gynaecology.

[64]  M. Brodie,et al.  Outcomes of newly diagnosed idiopathic generalized epilepsy syndromes in a non‐pediatric setting , 2007, Acta neurologica Scandinavica.

[65]  Philippe Ryvlin,et al.  Sudden unexpected death in epilepsy: current knowledge and future directions , 2008, The Lancet Neurology.

[66]  C. Bazil,et al.  Cross-sensitivity of skin rashes with antiepileptic drug use , 2008, Neurology.

[67]  R. Scott,et al.  The medical management of the epilepsies in children: conceptual and practical considerations , 2008, The Lancet Neurology.

[68]  A. Marson.  When to start antiepileptic drug treatment and with what evidence? , 2008, Epilepsia.

[69]  P. Pennell,et al.  Lamotrigine in pregnancy , 2008, Neurology.

[70]  B. Irwin,et al.  Topiramate in pregnancy , 2006, Neurology.

[71]  T. Tomson,et al.  Debate: Substitution of generic drugs in epilepsy: Is there cause for concern? , 2008, Epilepsia.

[72]  E. Faught,et al.  Nonadherence to antiepileptic drugs and increased mortality , 2008, Neurology.

[73]  B. Bourgeois,et al.  Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies , 2008, Epilepsia.

[74]  Y. Schiller,et al.  Quantifying the response to antiepileptic drugs , 2008, Neurology.

[75]  L. Gjerstad,et al.  Consequences of antiepileptic drug withdrawal: A randomized, double‐blind study (Akershus Study) , 2008, Epilepsia.

[76]  K. Meador,et al.  Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. , 2009, The New England journal of medicine.

[77]  T. Tomson,et al.  Pharmacokinetics of topiramate during pregnancy , 2009, Epilepsy Research.

[78]  A. Kanner.  Depression and epilepsy: a review of multiple facets of their close relation. , 2009, Neurologic clinics.

[79]  N. Gilhus,et al.  Pregnancy, delivery, and outcome for the child in maternal epilepsy , 2009, Epilepsia.

[80]  W. Hauser,et al.  Management issues for women with epilepsy—Focus on pregnancy (an evidence‐based review): II. Teratogenesis and perinatal outcomes , 2009, Epilepsia.

[81]  A. Aldenkamp,et al.  Adjustment of treatment increases quality of life in patients with epilepsy: a randomized controlled pragmatic trial , 2009, European journal of neurology.

[82]  Patrick Kwan,et al.  Epilepsy in later life , 2009, The Lancet Neurology.

[83]  Alicia B. Forinash,et al.  Drug Information Rounds Levetiracetam Use in Pregnancy , 2009, The Annals of pharmacotherapy.

[84]  S. Shorvon.  Drug treatment of epilepsy in the century of the ILAE: The first 50 years, 1909–1958 , 2009, Epilepsia.

[85]  M. Brodie,et al.  Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo‐controlled trial , 2009, Epilepsia.

[86]  E. Perucca.  Extended-Release Formulations of Antiepileptic Drugs: Rationale and Comparative Value , 2009, Epilepsy currents.

[87]  S. Mintzer,et al.  Should enzyme‐inducing antiepileptic drugs be considered first‐line agents? , 2009, Epilepsia.

[88]  W. Hauser,et al.  Practice Parameter update: Management issues for women with epilepsy—Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes , 2009, Neurology.

[89]  G. Mathern,et al.  Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies , 2009, Epilepsia.

[90]  Maria Paola Canevini,et al.  Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug‐refractory epilepsy , 2010, Epilepsia.

[91]  Shlomo Shinnar,et al.  Long-term mortality in childhood-onset epilepsy. , 2010, The New England journal of medicine.

[92]  D. Hesdorffer,et al.  An Update on Antiepileptic Drugs and Suicide: Are There Definitive Answers Yet? , 2010, Epilepsy currents.

[93]  K. Stavem,et al.  Placebo‐corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta‐analysis , 2010, Epilepsia.

[94]  R. Lancaster.  Lamotrigine in pregnancy , 2010 .

[95]  M. Loane,et al.  Valproic acid monotherapy in pregnancy and major congenital malformations. , 2010, The New England journal of medicine.

[96]  M. Backer,et al.  A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic Drugs , 2010, CNS drugs.

[97]  Paul Ciechanowski,et al.  PEARLS depression treatment for individuals with epilepsy: A randomized controlled trial , 2010, Epilepsy & Behavior.

[98]  T. Sprenger,et al.  Current practice and future directions in the prevention and acute management of migraine , 2010, The Lancet Neurology.

[99]  R. Berg,et al.  A Systematic Review and Meta-analysis , 2010 .

[100]  P. Ryvlin,et al.  Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta‐analysis , 2011, Epilepsia.

[101]  W. Hauser,et al.  Estimating risk for developing epilepsy , 2011, Neurology.

[102]  A. Kesselheim,et al.  Seizure Outcomes Following the Use of Generic versus Brand-Name Antiepileptic Drugs , 2010, Drugs.

[103]  Patrick Kwan,et al.  Combination Therapy in Epilepsy , 2012, Drugs.