Acoustical structured illumination for super-resolution ultrasound imaging

Structured illumination microscopy is an optical method to increase the spatial resolution of wide-field fluorescence imaging beyond the diffraction limit by applying a spatially structured illumination light. Here, we extend this concept to facilitate super-resolution ultrasound imaging by manipulating the transmitted sound field to encode the high spatial frequencies into the observed image through aliasing. Post processing is applied to precisely shift the spectral components to their proper positions in k-space and effectively double the spatial resolution of the reconstructed image compared to one-way focusing. The method has broad application, including the detection of small lesions for early cancer diagnosis, improving the detection of the borders of organs and tumors, and enhancing visualization of vascular features. The method can be implemented with conventional ultrasound systems, without the need for additional components. The resulting image enhancement is demonstrated with both test objects and ex vivo rat metacarpals and phalanges.Tali Ilovitsh et al. describe a new method, acoustical structured illumination, for generating super-resolution ultrasound images. The method applies principles from structured illumination microscopy and can be adapted to existing ultrasound systems without the need for additional components.

[1]  R. F. Wagner,et al.  Low Contrast Detectability and Contrast/Detail Analysis in Medical Ultrasound , 1983, IEEE Transactions on Sonics and Ultrasonics.

[2]  Zeev Zalevsky,et al.  Super-resolution using Barker-based array projected via spatial light modulator. , 2015, Optics letters.

[3]  T. Taxt,et al.  Two-dimensional noise-robust blind deconvolution of ultrasound images , 2001, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  W.F. Walker,et al.  The application of k-space in pulse echo ultrasound , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  M. Fink,et al.  Coherent plane-wave compounding for very high frame rate ultrasonography and transient elastography , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  Robert J. Eckersley,et al.  In Vivo Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using Microbubbles , 2015, IEEE Transactions on Medical Imaging.

[7]  T. V. Oughton,et al.  Breast imaging in coronal planes with simultaneous pulse echo and transmission ultrasound. , 1981, Science.

[8]  M. Tanter,et al.  Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging , 2015, Nature.

[9]  Explore Configuring,et al.  A Simulation Study to , 2004 .

[10]  K. Boone,et al.  Effect of skin impedance on image quality and variability in electrical impedance tomography: a model study , 1996, Medical and Biological Engineering and Computing.

[11]  Raoul Mallart,et al.  Improved imaging rate through simultaneous transmission of several ultrasound beams , 1992, SPIE Optics + Photonics.

[12]  Peer Fischer,et al.  Holograms for acoustics , 2016, Nature.

[13]  Hari Shroff,et al.  Resolution Doubling in Live, Multicellular Organisms via Multifocal Structured Illumination Microscopy , 2012, Nature Methods.

[14]  Zeev Zalevsky,et al.  Time multiplexing superresolution based on interference grating projection. , 2002, Applied optics.

[15]  K L Kraner.  Intrauterine fetal surgery. , 1965, Advances in veterinary science.

[16]  I. Mazin,et al.  Theory , 1934 .

[17]  M. Gustafsson.  Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Martin O Culjat,et al.  A review of tissue substitutes for ultrasound imaging. , 2010, Ultrasound in medicine & biology.

[19]  F. Luks,et al.  New and/or improved aspects of fetal surgery , 2011, Prenatal diagnosis.

[20]  R. Gerchberg.  A practical algorithm for the determination of phase from image and diffraction plane pictures , 1972 .

[21]  Cishen Zhang,et al.  Constrained Least Squares Filtering Algorithm for Ultrasound Image Deconvolution , 2006, IEEE Transactions on Biomedical Engineering.

[22]  Shy Shoham,et al.  Towards multifocal ultrasonic neural stimulation: pattern generation algorithms , 2010, Journal of neural engineering.

[23]  Gregg E. Trahey,et al.  A synthetic aperture study of aperture size in the presence of noise and in vivo clutter , 2013, Medical Imaging.

[24]  F. Kremkau,et al.  Artifacts in ultrasound imaging. , 1986, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[25]  J. Lippincott-Schwartz,et al.  Imaging Intracellular Fluorescent Proteins at Nanometer Resolution , 2006, Science.

[26]  G. Trahey,et al.  A seminar on k-space applied to medical ultrasound , 2000 .

[27]  M.S. Ibbini,et al.  A field conjugation method for direct synthesis of hyperthermia phases-array heating patterns , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[28]  Karel Fliegel,et al.  Comparison of image reconstruction methods for structured illumination microscopy , 2014, Photonics Europe.

[29]  Krzysztof R. Gorny,et al.  A Clinical Review of Focused Ultrasound Ablation With Magnetic Resonance Guidance: An Option for Treating Uterine Fibroids , 2008, Ultrasound quarterly.

[30]  N. Jaspers,et al.  Prenatal diagnosis of the Cockayne syndrome: survey of 15 years experience , 2006, Prenatal diagnosis.

[31]  H. Janka,et al.  Neutrino signal of electron-capture supernovae from core collapse to cooling , 2010 .

[32]  R. F. Wagner,et al.  Statistics of Speckle in Ultrasound B-Scans , 1983, IEEE Transactions on Sonics and Ultrasonics.

[33]  M. O'Donnell,et al.  Synthetic aperture imaging for small scale systems , 1995, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[34]  D Mendlovic,et al.  Superresolving optical system with time multiplexing and computer decoding. , 1999, Applied optics.

[35]  R. Waag,et al.  Propagation and backpropagation for ultrasonic wavefront design , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[36]  J. Arendt.  Paper presented at the 10th Nordic-Baltic Conference on Biomedical Imaging: Field: A Program for Simulating Ultrasound Systems , 1996 .

[37]  G. Navon,et al.  Bypassing absorbing objects in focused ultrasound using computer generated holographic technique. , 2011, Medical physics.

[38]  Michael J Rust,et al.  Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) , 2006, Nature Methods.

[39]  M. Gustafsson.  Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy , 2000, Journal of microscopy.

[40]  Katherine W Ferrara,et al.  Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia , 2016, Physics in medicine and biology.

[41]  W.F. Walker,et al.  Optimal apodization design for medical ultrasound using constrained least squares part I: theory , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[42]  G. Farhat,et al.  Diagnostic ultrasound Imaging : Inside out , 2004 .

[43]  Jörg Enderlein,et al.  Image scanning microscopy. , 2010, Physical review letters.

[44]  N C Nanda,et al.  Evaluation of aortic insufficiency by Doppler color flow mapping. , 1987, Journal of the American College of Cardiology.

[45]  A. Stavros,et al.  Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. , 1995, Radiology.

[46]  Eigil Samset,et al.  Acoustic output of multi-line transmit beamforming for fast cardiac imaging: a simulation study , 2015, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[47]  C Dunsby,et al.  Acoustic super-resolution with ultrasound and microbubbles , 2013, Physics in medicine and biology.

[48]  C.A. Cain,et al.  Multiple-focus ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[49]  Jan D'hooge,et al.  Multi-transmit beam forming for fast cardiac imaging-a simulation study , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[50]  E. Abbe.  Beiträge zur Theorie des Mikroskops und der mikroskopischen Wahrnehmung , 1873 .

[51]  Edward D Light,et al.  Progress in Ring Array Transducers for Real-Time 3D Ultrasound Guidance of Cardiac Interventional Devices , 2011, Ultrasonic imaging.