Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
暂无分享,去创建一个
[1] Hilko van der Voet,et al. Identification of the SAAT Gene Involved in Strawberry Flavor Biogenesis by Use of DNA Microarrays , 2000, Plant Cell.
[2] P M Dewick. The biosynthesis of C5-C25 terpenoid compounds. , 1997, Natural product reports.
[3] T. Nishino,et al. Conversion from Archaeal Geranylgeranyl Diphosphate Synthase to Farnesyl Diphosphate Synthase , 1997, The Journal of Biological Chemistry.
[4] T. Saito,et al. Canthaxanthin biosynthesis by the conversion of methylene to keto groups in a hydrocarbon beta-carotene by a single gene. , 1995, Biochemical and biophysical research communications.
[5] David E. Cane,et al. Isoprenoids including carotenoids and steroids , 1999 .
[6] B. Blagg,et al. Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. , 2002, Journal of the American Chemical Society.
[7] Palle Schneider,et al. Directed evolution of a fungal peroxidase , 1999, Nature Biotechnology.
[8] J. Saunders,et al. Phytochemical Diversity and Redundancy in Ecological Interactions , 1996, Recent Advances in Phytochemistry.
[9] Manuel J T Carrondo,et al. Biochemical engineering. , 2004, Current opinion in biotechnology.
[10] G. Sandmann,et al. Carotenoid biosynthesis in microorganisms and plants. , 1994, European journal of biochemistry.
[11] S. Al‐Babili,et al. Carotenoid oxygenases: cleave it or leave it. , 2003, Trends in plant science.
[12] M. Kobayashi,et al. Singlet oxygen quenching ability of astaxanthin esters from the green alga Haematococcus pluvialis , 1999, Biotechnology Letters.
[13] R. W. Tuveson,et al. Role of cloned carotenoid genes expressed in Escherichia coli in protecting against inactivation by near-UV light and specific phototoxic molecules , 1988, Journal of bacteriology.
[14] J. Avalos,et al. A single gene for lycopene cyclase, phytoene synthase, and regulation of carotene biosynthesis in Phycomyces. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[15] T. Koyama,et al. Construction of a chiral center by use of the stereospecificity of prenyltransferase. , 1977, Journal of the American Chemical Society.
[16] A. Nakano,et al. The Escherichia coli Homologue of Yeast Rer2, a Key Enzyme of Dolichol Synthesis, Is Essential for Carrier Lipid Formation in Bacterial Cell Wall Synthesis , 1999, Journal of bacteriology.
[17] J. von Lintig,et al. Molecular analysis of vitamin A formation: cloning and characterization of beta-carotene 15,15'-dioxygenases. , 2001, Archives of biochemistry and biophysics.
[18] Eric A. Johnson,et al. Carotenoids protectPhaffia rhodozyma against singlet oxygen damage , 1995, Journal of Industrial Microbiology.
[19] T. Nishino,et al. An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase. , 2003, European journal of biochemistry.
[20] J. H. Marshall,et al. Pigments of Staphylococcus aureus, a series of triterpenoid carotenoids , 1981, Journal of bacteriology.
[21] P. Fraser,et al. Carotenoid biosynthesis in wild type and mutant strains of Mucor circinelloides. , 1996, Biochimica et biophysica acta.
[22] Manfred T Reetz,et al. A Method for High-Throughput Screening of Enantioselective Catalysts. , 1999, Angewandte Chemie.
[23] G. Sandmann,et al. Molecular evolution of lycopene cyclases involved in the formation of carotenoids with ionone end groups. , 2000, Biochemical Society transactions.
[24] A. Maureen Rouhi,et al. Rediscovering natural products , 2003 .
[25] M. Luckner,et al. [What is secondary metabolism?]. , 1971, Die Pharmazie.
[26] F. Arnold,et al. Directed Evolution Library Creation , 2003 .
[27] M. Wyss,et al. Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. , 2000, Biochemical and biophysical research communications.
[28] T. Koyama,et al. Conversion from Farnesyl Diphosphate Synthase to Geranylgeranyl Diphosphate Synthase by Random Chemical Mutagenesis (*) , 1996, The Journal of Biological Chemistry.
[29] W. Patrick Walters,et al. A guide to drug discovery: Designing screens: how to make your hits a hit , 2003, Nature Reviews Drug Discovery.
[30] D A Hughes,et al. Effects of carotenoids on human immune function , 1999, Proceedings of the Nutrition Society.
[31] R. Croteau,et al. Monoterpene Synthases from Common Sage (Salvia officinalis)* , 1998, The Journal of Biological Chemistry.
[32] G. Sandmann,et al. Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways. , 2001, Biochimica et biophysica acta.
[33] A. Demain,et al. Pharmaceutically active secondary metabolites of microorganisms , 1999, Applied Microbiology and Biotechnology.
[34] W. Doolittle,et al. The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways , 2000, Molecular microbiology.
[35] A. Collins. Carotenoids and genomic stability. , 2001, Mutation research.
[36] E. Cerdá-Olmedo. [27] Carotene mutants of Phycomyces , 1985 .
[37] R. Croteau,et al. Germacrene C synthase from Lycopersicon esculentum cv. VFNT cherry tomato: cDNA isolation, characterization, and bacterial expression of the multiple product sesquiterpene cyclase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[38] R. Firn,et al. Natural products--a simple model to explain chemical diversity. , 2003, Natural product reports.
[39] H. Kleinig,et al. New C30-Carotenoic Acid Glucosyl Esters from Pseudomonas rhodos , 1979 .
[40] J. Hearst,et al. Introduction of new carotenoids into the bacterial photosynthetic apparatus by combining the carotenoid biosynthetic pathways of Erwinia herbicola and Rhodobacter sphaeroides , 1994, Journal of bacteriology.
[41] A. Bendich. Recent advances in clinical research involving carotenoids , 1994 .
[42] E. Gantt,et al. Cloning and Functional Analysis of the β-Carotene Hydroxylase of Arabidopsis thaliana* , 1996, The Journal of Biological Chemistry.
[43] M. Lidstrom,et al. Genetic Characterization of the Carotenoid Biosynthetic Pathway in Methylobacterium extorquens AM1 and Isolation of a Colorless Mutant , 2003, Applied and Environmental Microbiology.
[44] T. Maoka,et al. Detailed biosynthetic pathway to decaprenoxanthin diglucoside in Corynebacterium glutamicum and identification of novel intermediates , 2001, Archives of Microbiology.
[45] Kyoko Nakamura,et al. Singlet oxygen quenching ability of naturally occurring carotenoids , 1994, Lipids.
[46] R. Firn,et al. The evolution of secondary metabolism – a unifying model , 2000, Molecular microbiology.
[47] R. Cogdell,et al. Functional assembly of the foreign carotenoid lycopene into the photosynthetic apparatus of Rhodobacter sphaeroides, achieved by replacement of the native 3‐step phytoene desaturase with its 4‐step counterpart from Erwinia herbicola , 2002, Molecular microbiology.
[48] S. Ouchane,et al. Pleiotropic Effects of puf Interposon Mutagenesis on Carotenoid Biosynthesis in Rubrivivax gelatinosus , 1997, The Journal of Biological Chemistry.
[49] N. Krinsky. The biological properties of carotenoids , 1994 .
[50] W. Schwab,et al. Metabolome diversity: too few genes, too many metabolites? , 2003, Phytochemistry.
[51] G. Sandmann,et al. Expression of Erwinia uredovora Phytoene Desaturase in Synechococcus PCC7942 Leading to Resistance against a Bleaching Herbicide , 1994, Plant physiology.
[52] M. Kawamukai,et al. The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli , 1997, Journal of bacteriology.
[53] S. Hessel,et al. Identification and Characterization of a Mammalian Enzyme Catalyzing the Asymmetric Oxidative Cleavage of Provitamin A* , 2001, The Journal of Biological Chemistry.
[54] F. Khachik,et al. Cancer prevention by natural carotenoids. , 1997, Journal of cellular biochemistry. Supplement.
[55] E. Harrison,et al. Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids. , 2001, The Journal of biological chemistry.
[56] F. Arnold,et al. Functional Expression of a Fungal Laccase in Saccharomyces cerevisiae by Directed Evolution , 2003, Applied and Environmental Microbiology.
[57] G. Sandmann,et al. Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation. , 2001, European journal of biochemistry.
[58] George Britton,et al. UV/Visible Spectroscopy , 1995 .
[59] J. H. Marshall,et al. Proposed pathway of triterpenoid carotenoid biosynthesis in Staphylococcus aureus: evidence from a study of mutants , 1981, Journal of bacteriology.
[60] M. Reetz,et al. Second-generation MS-based high-throughput screening system for enantioselective catalysts and biocatalysts , 2002 .
[61] F. Arnold,et al. Directed evolution converts subtilisin E into a functional equivalent of thermitase. , 1999, Protein engineering.
[62] W. Willett,et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. , 1999, The American journal of clinical nutrition.
[63] W. Stemmer. Rapid evolution of a protein in vitro by DNA shuffling , 1994, Nature.
[64] K. Phadwal,et al. Carotenoid biosynthetic pathway: molecular phylogenies and evolutionary behavior of crt genes in eubacteria. , 2005, Gene.
[65] David H Sherman,et al. An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. , 2004, Protein engineering, design & selection : PEDS.
[66] T. Goodwin,et al. Studies in carotenogenesis. V. Carotene production by various mutants of Phycomyces blakesleeanus and by Phycomyces nitens. , 1952, The Biochemical journal.
[67] M. Lucas,et al. Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtl in transgenic plants showing an increase of beta-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon. , 1993, The Plant journal : for cell and molecular biology.
[68] B. Katzenellenbogen,et al. Directed Evolution of Human Estrogen Receptor Variants with Significantly Enhanced Androgen Specificity and Affinity* , 2004, Journal of Biological Chemistry.
[69] R. Sager,et al. Pigments and Photosynthesis in a Carotenoid-Deficient Mutant Of chlamydomonas , 1958, Nature.
[70] J. Hearst,et al. Genetics and molecular biology of carotenoid pigment biosynthesis , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[71] S. Yu,et al. Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase* , 2001, The Journal of Biological Chemistry.
[72] J. Chappell. Biochemistry and Molecular Biology of the Isoprenoid Biosynthetic Pathway in Plants , 1995 .
[73] A. Scott,et al. Biosynthesis of Natural Products , 1974, Science.
[74] N. Misawa,et al. Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level , 1995, Journal of bacteriology.
[75] J. Avalos,et al. Gibberella fujikuroi mutants obtained with UV radiation and N-methyl-N'-nitro-N-nitrosoguanidine , 1985, Applied and environmental microbiology.
[76] W. Stemmer,et al. Molecular evolution of an arsenate detoxification pathway by DNA shuffling , 1997, Nature Biotechnology.
[77] T. Koyama,et al. One-pot syntheses of the sex pheromone homologs of a codling moth, Laspeyresia promonella L. , 2000 .
[78] Richard F. Taylor,et al. Bacterial triterpenoids. , 1984, Microbiological reviews.
[79] W. Hess,et al. A novel type of lycopene ε-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4 , 2003, Archives of Microbiology.
[80] G. Sandmann,et al. Expression and biochemical characterization of the 1-HO-carotenoid methylase CrtF from Rhodobacter capsulatus. , 2003, FEMS microbiology letters.
[81] B. S. Henry,et al. Plant pigments as natural food colours. , 1986, Endeavour.
[82] Charanjit Kaur,et al. Antioxidants in fruits and vegetables – the millennium’s health , 2001 .
[83] D. Saul,et al. Molecular diversity of thermophilic cellulolytic and hemicellulolytic bacteria , 1999 .
[84] P. Beyer,et al. Analysis in Vitro of the Enzyme CRTISO Establishes a Poly-cis-Carotenoid Biosynthesis Pathway in Plants1 , 2004, Plant Physiology.
[85] C. Poulter,et al. Chain elongation in the isoprenoid biosynthetic pathway. , 1997, Current opinion in chemical biology.
[86] N. Misawa,et al. Structural and functional analysis of a lycopene β‐monocyclase gene isolated from a unique marine bacterium that produces myxol , 2003, FEBS letters.
[87] M. Delbrück,et al. Complementation between mutants of Phycomyces deficient with respect to carotenogenesis , 2004, Molecular and General Genetics MGG.
[88] David J Newman,et al. Natural products as sources of new drugs over the period 1981-2002. , 2003, Journal of natural products.
[89] F. Arnold,et al. How enzymes adapt: lessons from directed evolution , 2001, Trends in biochemical sciences.
[90] R. Jensen. Enzyme recruitment in evolution of new function. , 1976, Annual review of microbiology.
[91] T. Kaneko,et al. Identification of a gene required for cis-to-trans carotene isomerization in carotenogenesis of the cyanobacterium Synechocystis sp. PCC 6803. , 2001, Plant & cell physiology.
[92] T. Koyama,et al. SUBSTRATE SPECIFICITY OF FARNESYL DIPHOSPHATE SYNTHASE FROM BACILLUS STEAROTHERMOPHILUS , 1995 .
[93] C. Poulter,et al. Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH. , 2002, Journal of the American Chemical Society.
[94] M. Oh,et al. Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli. , 1999, Biotechnology and bioengineering.
[95] Akio Saito,et al. Substrate specificity of farnesylpyrophosphate synthetase. Application to asymmetric synthesis , 1980 .
[96] P. Zurer. BIOSYNTHESIS OF SQUALENE: Cationic intermediate identified in path that leads to key cholesterol precursor , 1997 .
[97] M. Karp,et al. Rapid screening method for the detection of antimicrobial substances. , 2004, Journal of microbiological methods.
[98] T. Koyama,et al. Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: analysis using mutated enzymes and artificial allylic substrates. , 1998, Journal of biochemistry.
[99] C. Eugster,et al. Carotinoidsynthesen VIII. Synthese des Dodecapreno‐β‐carotins , 1951 .
[100] J. Liao,et al. Alteration of Product Specificity of Rhodobacter sphaeroides Phytoene Desaturase by Directed Evolution* , 2001, The Journal of Biological Chemistry.
[101] M. Lakshman. Alpha and omega of carotenoid cleavage. , 2004, The Journal of nutrition.
[102] M. Kawamukai,et al. Dimer Formation of Octaprenyl-diphosphate Synthase (IspB) Is Essential for Chain Length Determination of Ubiquinone* , 2001, The Journal of Biological Chemistry.
[103] T. Nishino,et al. Conversion of Product Specificity of Archaebacterial Geranylgeranyl-diphosphate Synthase , 1996, The Journal of Biological Chemistry.
[104] P. Facchini,et al. Gene family for an elicitor-induced sesquiterpene cyclase in tobacco. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[105] J. Liao,et al. Metabolic engineering of isoprenoids. , 2001, Metabolic engineering.
[106] G. Sandmann,et al. The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli. , 1999, Trends in biotechnology.
[107] Frances H. Arnold,et al. Directed evolution library creation : methods and protocols , 2003 .
[108] C. Chou,et al. Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination* , 2004, Journal of Biological Chemistry.
[109] G. F. Joyce,et al. Mutagenic PCR. , 1994, PCR methods and applications.
[110] G. Habermehl,et al. ReviewPure appl. Chem: Rinehart, K. L., et al. Marine natural products as sources of antiviral, antimicrobial, and antineoplastic Agents. 53, 795 (1981). (K. L. Rinehart, University of Illinois, Urbana, IL 61801, U.S.A.) , 1983 .
[111] Frances H. Arnold,et al. A C35 Carotenoid Biosynthetic Pathway , 2003, Applied and Environmental Microbiology.
[112] E. Bejarano,et al. ζ-Carotene and other carotenes in a Phycomyces mutant , 1987 .
[113] J. Liao,et al. REVIEW Metabolic Engineering of Isoprenoids , 2001 .
[114] C. Schmidt-Dannert,et al. Engineering novel carotenoids in microorganisms. , 2000, Current opinion in biotechnology.
[115] Frances H. Arnold,et al. Molecular breeding of carotenoid biosynthetic pathways , 2000, Nature Biotechnology.
[116] P. Bramley. The in Vitro Biosynthesis of Carotenoids , 1985 .
[117] G. Sandmann,et al. Heterologous expression, purification, and enzymatic characterization of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus. , 2003, Archives of biochemistry and biophysics.
[118] E. Pichersky,et al. Volatile Ester Formation in Roses. Identification of an Acetyl-Coenzyme A. Geraniol/Citronellol Acetyltransferase in Developing Rose Petals1 , 2003, Plant Physiology.
[119] J. Sacchettini,et al. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. , 1994, Biochemistry.
[120] M. Kuntz,et al. Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts. , 1995, The Plant journal : for cell and molecular biology.
[121] D. Pompon,et al. High efficiency family shuffling based on multi-step PCR and in vivo DNA recombination in yeast: statistical and functional analysis of a combinatorial library between human cytochrome P450 1A1 and 1A2. , 2000, Nucleic acids research.
[122] Manfred T. Reetz,et al. A Practical NMR‐Based High‐Throughput Assay for Screening Enantioselective Catalysts and Biocatalysts , 2002 .
[123] E. Bejarano,et al. In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[124] G. Sandmann,et al. ζ-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene , 2005, Planta.
[125] M. Madigan,et al. The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4′-diaponeurosporene, not neurosporene , 1997, Archives of Microbiology.
[126] P. Nair,et al. Studies on the bioavailability of the provitamin A carotenoid, β-carotene, using human exfoliated colonic epithelial cells , 2004, British Journal of Nutrition.
[127] K. Poralla,et al. Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus , 1994, Journal of bacteriology.
[128] W. Hess,et al. A novel type of lycopene epsilon-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4. , 2003, Archives of microbiology.
[129] M. D. de la Guardia,et al. A carotenogenic enzyme aggregate in Phycomyces: evidence from quantitive complementation. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[130] T. Nishino,et al. The role of histidine‐114 of Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain‐length determination , 2000, FEBS letters.
[131] P. Campochiaro,et al. Cloning and characterization of a human β, β-carotene-15, 15'-dioxygenase that is highly expressed in the retinal pigment epithelium , 2001 .
[132] J. Bertram. Carotenoids and gene regulation. , 2009, Nutrition reviews.
[133] G. Britton,et al. Oxidation of carotenoids by free radicals: relationship between structure and reactivity. , 1997, Biochimica et biophysica acta.
[134] C. Poulter,et al. Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity. , 2000, Biochemistry.
[135] V. Davisson,et al. Farnesyl-Diphosphate Synthase. Interplay Between Substrate Topology, Stereochemistry, and Regiochemistry in Electrophilic Alkylations. , 1993 .
[136] G. Armstrong. 2.12 – Carotenoid Genetics and Biochemistry , 1999 .
[137] F. Arnold,et al. Method to protect a targeted amino acid residue during random mutagenesis. , 2003, Nucleic acids research.
[138] G. Sandmann. Molecular evolution of carotenoid biosynthesis from bacteria to plants , 2002 .
[139] D. Robbins,et al. PCR-based random mutagenesis using manganese and reduced dNTP concentration. , 1997, BioTechniques.
[140] E. Gantt,et al. One ring or two? Determination of ring number in carotenoids by lycopene ɛ-cyclases , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[141] T. Nishino,et al. Protein design of geranyl diphosphate synthase. Structural features that define the product specificities of prenyltransferases. , 1999, Journal of biochemistry.
[142] B. M. Lange,et al. Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[143] T. Koyama,et al. Dramatic changes in the substrate specificities of prenyltransferase by a single amino acid substitution , 2002 .
[144] J. Bohlmann,et al. Sesquiterpene Synthases from Grand Fir (Abies grandis) , 1998, The Journal of Biological Chemistry.
[145] F. Arnold,et al. Evolution of the C30 Carotenoid Synthase CrtM for Function in a C40 Pathway , 2002, Journal of bacteriology.
[146] G. Lauro. A primer on natural colors , 1991 .
[147] G. Giuliano,et al. Carotenoid isomerase: a tale of light and isomers. , 2002, Trends in plant science.
[148] R. Ghosh,et al. A null lesion in the rhodopin 3,4-desaturase of Rhodospirillum rubrum unmasks a cryptic branch of the carotenoid biosynthetic pathway. , 1998, Biochemistry.
[149] J. Zeevaart. Metabolism and physiology of abscisic acid , 1988 .
[150] G. Britton,et al. A series of mutant strains of Scenedesmus obliquus with abnormal carotenoid compositions , 1977, Archives of Microbiology.
[151] M. Leuenberger,et al. The Reaction Mechanism of the Enzyme-Catalyzed Central Cleavage of β-Carotene to Retinal. , 2001, Angewandte Chemie.
[152] G. Sandmann,et al. A carotenogenic gene cluster from Brevibacterium linens with novel lycopene cyclase genes involved in the synthesis of aromatic carotenoids , 2000, Molecular and General Genetics MGG.
[153] M. Wyss,et al. Cloning and Expression of ,-Carotene 15,15'-Dioxygenase , 2000 .
[154] C. Schmidt-Dannert,et al. Metabolic engineering towards biotechnological production of carotenoids in microorganisms , 2002, Applied Microbiology and Biotechnology.
[155] T. Nishino,et al. A Pathway Where Polyprenyl Diphosphate Elongates in Prenyltransferase , 1998, The Journal of Biological Chemistry.
[156] J C Sacchettini,et al. Regulation of product chain length by isoprenyl diphosphate synthases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[157] T. Koyama,et al. Enzymatic Aspects of Isoprenoid Chain Elongation. , 1998, Chemical reviews.
[158] P. Ortiz de Montellano,et al. Substrate selectivity of squalene synthetase. , 1977, Biochemistry.
[159] G. Sandmann,et al. Novel hydroxycarotenoids with improved antioxidative properties produced by gene combination in Escherichia coli , 2000, Nature Biotechnology.
[160] U. Mitzka-Schnabel,et al. Carotenoid synthesis in Neurospora crassa. , 1985, Methods in enzymology.
[161] R. Croteau,et al. Biochemical characterization of a spearmint mutant that resembles peppermint in monoterpene content. , 1991, Plant physiology.
[162] B. Blagg,et al. Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene , 1996 .
[163] T. Koyama,et al. Polyprenyl diphosphate synthases. , 1997, Sub-cellular biochemistry.
[164] N. Misawa,et al. Synthesis of atypical cyclic and acyclic hydroxy carotenoids in Escherichia coli transformants. , 1997, Journal of biotechnology.
[165] J. Avalos,et al. Mutants of the carotene cyclase domain of al-2 from Neurospora crassa , 2002, Zeitschrift für Induktive Abstammungs- und Vererbungslehre.
[166] M. A. Nazareno,et al. Singlet Molecular Oxygen Quenching Ability of Carotenoids in a Reverse‐micelle Membrane Mimetic System ¶ , 2002, Photochemistry and photobiology.
[167] M. Yčas,et al. On earlier states of the biochemical system. , 1974, Journal of theoretical biology.
[168] N. Walton,et al. Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura. , 1999, Phytochemistry.
[169] S. Schwartz,et al. Characterization of a Novel Carotenoid Cleavage Dioxygenase from Plants* , 2001, The Journal of Biological Chemistry.
[170] N. Misawa,et al. The carotenoid 7,8-dihydro-psi end group can be cyclized by the lycopene cyclases from the bacterium Erwinia uredovora and the higher plant Capsicum annuum. , 1996, European journal of biochemistry.
[171] C. M. Aragón,et al. Substrate transfer in carotene biosynthesis in Phycomyces. , 1981, European journal of biochemistry.
[172] Janet M Thornton,et al. Pathway evolution, structurally speaking. , 2002, Current opinion in structural biology.
[173] T. Nishino,et al. Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. , 1990, Journal of biochemistry.
[174] J. Keasling,et al. Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization. , 2001, Metabolic engineering.
[175] R. Croteau,et al. Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-beta-farnesene. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[176] C. Rice-Evans,et al. Why do we expect carotenoids to be antioxidants in vivo? , 1997, Free radical research.
[177] S. Takaichi,et al. Pigment Composition of Two Pigment-Protein Complexes Derived from Anaerobically and Semi-Aerobically Grown Rubrivivax gelatinosus, and Identification of a New Keto-Carotenoid, 2-Ketospirilloxanthin , 1999 .
[178] C. Schmidt-Dannert,et al. Biosynthesis of structurally novel carotenoids in Escherichia coli. , 2003, Chemistry & biology.
[179] M. Starr,et al. The ketonic carotenoid canthaxanthin isolated from a colour mutant of Corynebacterium michiganense. , 1954, The Biochemical journal.
[180] B. Hsu,et al. Cloning and expression of a putative cytochrome P450 gene that influences the colour of Phalaenopsis flowers , 2003, Biotechnology Letters.
[181] D. McCarty,et al. Specific oxidative cleavage of carotenoids by VP14 of maize. , 1997, Science.
[182] P. Dewick. The biosynthesis of C 5 –C 25 terpenoid compounds , 1999 .
[183] G. Britton,et al. Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis , 2002, FEBS letters.
[184] P. Beyer,et al. Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. , 2000, Science.
[185] K. Kitahama,et al. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. , 2001, Biochimica et biophysica acta.
[186] N. Misawa,et al. Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli , 1990, Journal of bacteriology.
[187] J. von Lintig,et al. Filling the Gap in Vitamin A Research , 2000, The Journal of Biological Chemistry.
[188] R. Siegel,et al. Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization. , 1997, BioTechniques.
[189] T. Kawasaki,et al. Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution. , 2003, Journal of biochemistry.
[190] Vishwakarma Singh,et al. Hybrid systems through natural product leads: an approach towards new molecular entities. , 2002, Chemical Society reviews.
[191] T. Nishino,et al. Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations. , 2002, Biochemical and biophysical research communications.
[192] G. Sandmann. Combinatorial Biosynthesis of Carotenoids in a Heterologous Host: A Powerful Approach for the Biosynthesis of Novel Structures , 2002, Chembiochem : a European journal of chemical biology.
[193] G. Schiefer,et al. The Substrate Specificity ofβ,β-Carotene 15,15′-Monooxygenase , 2001 .
[194] C. Schmidt-Dannert,et al. High-Level Production of Porphyrins in Metabolically Engineered Escherichia coli: Systematic Extension of a Pathway Assembled from Overexpressed Genes Involved in Heme Biosynthesis , 2003, Applied and Environmental Microbiology.
[195] M. Oh,et al. Directed Evolution of Metabolically Engineered Escherichiacoli for Carotenoid Production , 2000, Biotechnology progress.
[196] M. Brodelius,et al. Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum. , 2002, European journal of biochemistry.
[197] B. Pogson,et al. Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. , 1996, The Plant cell.
[198] K. Tanaka,et al. Molecular cloning and mutational analysis of the ddsA gene encoding decaprenyl diphosphate synthase from Gluconobacter suboxydans. , 1998, European journal of biochemistry.
[199] J. Bohlmann,et al. cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis). , 1999, Archives of biochemistry and biophysics.
[200] A. H. Wang,et al. Structure, mechanism and function of prenyltransferases. , 2002, European journal of biochemistry.
[201] T. Nishino,et al. Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase , 1989, Journal of bacteriology.
[202] R. Firn,et al. An Explanation of Secondary Product “Redundancy” , 1996 .
[203] R. L. Ausich. Production of carotenoids by recombinant DNA technology , 1994 .
[204] C. Reeves. The Enzymology of Combinatorial Biosynthesis , 2003, Critical reviews in biotechnology.
[205] Yvonne Genzel,et al. Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution. , 2004, Organic letters.
[206] G. Sandmann,et al. Heterologous production of two unusual acyclic carotenoids, 1,1'-dihydroxy-3,4-didehydrolycopene and 1-hydroxy-3,4,3',4'-tetradehydrolycopene by combination of the crtC and crtD genes from Rhodobacter and Rubrivivax. , 2002, Journal of biotechnology.
[207] E. Gantt,et al. One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[208] Herbert Waldmann,et al. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. , 2002, Angewandte Chemie.
[209] F. Arnold,et al. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[210] P. Campochiaro,et al. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. , 2001, Genomics.
[211] E. Viroonchatapan,et al. Geranylgeranyl diphosphate synthases from Scoparia dulcis and Croton sublyratus. cDNA cloning, functional expression, and conversion to a farnesyl diphosphate synthase. , 2000, Chemical & pharmaceutical bulletin.
[212] K. Wang,et al. Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution. , 1999, Trends in biochemical sciences.
[213] S. Chandrasekhar,et al. Natural product hybrids as new leads for drug discovery. , 2003, Angewandte Chemie.
[214] M. Kates,et al. Exclusive formation of all-trans-phytoene by a colorless mutant of Halobacterium halobium. , 1980, Canadian journal of microbiology.
[215] J. Hirschberg,et al. Metabolic engineering of astaxanthin production in tobacco flowers , 2000, Nature Biotechnology.
[216] T. Koyama,et al. Artificial substrates for undecaprenyl diphosphate synthase from Micrococcus luteus B-P 26 , 2000 .
[217] Preparing libraries in Saccharomyces cerevisiae. , 2003, Methods in molecular biology.
[218] M. D. de la Guardia,et al. An enzyme complex for the dehydrogenation of phytoene in Phycomyces. , 1976, European journal of biochemistry.
[219] T. Ohshima,et al. Carotenoids as antioxidants to prevent photooxidation , 2002 .
[220] R. Cogdell,et al. Carotenoid diversity: a modular role for the phytoene desaturase step , 1998 .
[221] N. Misawa,et al. Expression in Escherichia coli, purification, and reactivation of the recombinant Erwinia uredovora phytoene desaturase. , 1992, The Journal of biological chemistry.
[222] N. Misawa,et al. Production of new carotenoids, astaxanthin glucosides, by Escherichia coli transformants carrying carotenoid biosynthesis genes , 1998 .
[223] B. Camara,et al. Biosynthesis of the Food and Cosmetic Plant Pigment Bixin (Annatto) , 2003, Science.
[224] S. Andersson,et al. Biochemical Properties of Purified Recombinant Human β-Carotene 15,15′-Monooxygenase* , 2002, The Journal of Biological Chemistry.
[225] T. Koyama,et al. Mechanism of product chain length determination for heptaprenyl diphosphate synthase from Bacillus stearothermophilus. , 2000, European journal of biochemistry.
[226] R. Firn,et al. On the evolution of plant secondary chemical diversity , 1991 .
[227] T. Nishino,et al. A Role of the Amino Acid Residue Located on the Fifth Position before the First Aspartate-rich Motif of Farnesyl Diphosphate Synthase on Determination of the Final Product* , 1996, The Journal of Biological Chemistry.
[228] Blaine A. Pfeifer,et al. Biosynthesis of Polyketides in Heterologous Hosts , 2001, Microbiology and Molecular Biology Reviews.
[229] S. T. Liu,et al. Cloning and regulation of Erwinia herbicola pigment genes , 1986, Journal of bacteriology.
[230] F. Arnold,et al. Evolution of a Pathway to Novel Long-Chain Carotenoids , 2004, Journal of bacteriology.
[231] J. Avalos,et al. Carotenoid mutants of Gibberella fujikuroi , 1987, Current Genetics.
[232] S. Takaichi,et al. Carotenogenesis Pathway of Novel Carotenoid Glucoside Mycolic Acid Esters in Rhodococcus rhodochrous Using Carotenogenesis Mutants and Inhibitors. , 1999, Bioscience, biotechnology, and biochemistry.
[233] J. Hirschberg,et al. Biosynthesis of ketocarotenoids in transgenic cyanobacteria expressing the algal gene for β‐C‐4‐oxygenase, crtO , 1997, FEBS letters.
[234] C. Poulter,et al. Biosynthesis of non-head-to-tail isoprenoids. Synthesis of 1′-1 and 1′-3 structures by recombinant yeast squalene synthase , 1995 .