Mean carbon dioxide tension in the brain after carbonic anhydrase inhibition

1. Measurements of the CO2 tensions in arterial blood, in blood from the superior sagittal sinus, in cisternal cerebrospinal fluid, and on the surface of the cerebral cortex were made in spontaneously breathing anaesthetized cats and rats after inhibition of carbonic anhydrase with acetazolamide in doses of 50‐150 mg/kg.

[1]  D. Rall,et al.  Effect of certain drugs on cerebrospinal fluid production in the dog , 1964 .

[2]  W. Ashby,et al.  Relative distribution patterns of three brain enzymes, carbonic anhydrase, choline esterase and acetyl phosphatase. , 1952, The American journal of physiology.

[3]  J. Mithoefer Inhibition of carbonic anhydrase: its effect on carbon dioxide elimination by the lungs. , 1959, Journal of applied physiology.

[4]  T. Maren,et al.  The pharmacology of acetazolamide as related to cerebrospinal fluid and the treatment of hydrocephalus. , 1960, Bulletin of the Johns Hopkins Hospital.

[5]  R. Clark,et al.  Respiratory effects of carbonic anhydrase inhibition in the trained unanesthetized dog. , 1958, Journal of applied physiology.

[6]  B. Siesjö A Method for Continuous Measurement of the Carbon Dioxide Tension on the Cerebral Cortex , 1961 .

[7]  J. Meyer,et al.  Interaction of cerebral hemodynamics and metabolism , 1961, Neurology.

[8]  T. Maren,et al.  Effects of carbonic anhydrase inhibition on cerebrospinal and intraocular fluids in the dog. , 2009, Acta pharmacologica et toxicologica.

[9]  A Krogh,et al.  The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue , 1919, The Journal of physiology.

[10]  R. Karler,et al.  The role of carbon dioxide in the nervous system. , 1960, Anesthesiology.

[11]  D. Woodbury,et al.  Carbonic anhydrase inhibition and brain electrolyte composition. , 1960, The American journal of physiology.

[12]  E. Giacobini A CYTOCHEMICAL STUDY OF THE LOCALIZATION OF CARBONIC ANHYDRASE IN THE NERVOUS SYSTEM , 1962, Journal of neurochemistry.