Genetic Networks in Osseointegration

Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.

[1]  G. Huynh-Ba,et al.  Transcriptional profiling of osseointegration in humans. , 2011, Clinical oral implants research.

[2]  A. Freemont,et al.  Localization of pro-collagen type II mRNA and collagen type II in the healing tooth socket of the rat. , 1995, Archives of oral biology.

[3]  Andreas Möglich,et al.  Structure and signaling mechanism of Per-ARNT-Sim domains. , 2009, Structure.

[4]  Patrick J Prendergast,et al.  Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia‐inducible factor (HIF)‐1α , 2008, Journal of cellular physiology.

[5]  M. Monjo,et al.  Correlation between molecular signals and bone bonding to titanium implants. , 2012, Clinical oral implants research.

[6]  A. Blom,et al.  The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces. , 2010, Biomaterials.

[7]  Hideki Aita,et al.  Glycosaminoglycan degradation reduces mineralized tissue-titanium interfacial strength. , 2006, Journal of biomedical materials research. Part A.

[8]  C. Tifft,et al.  Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta , 2007, Nature Genetics.

[9]  Kazuo Takeuchi,et al.  Enhanced intrinsic biomechanical properties of osteoblastic mineralized tissue on roughened titanium surface. , 2005, Journal of biomedical materials research. Part A.

[10]  K. Sinha,et al.  Genetic and molecular control of osterix in skeletal formation , 2013, Journal of cellular biochemistry.

[11]  J. Friedberg,et al.  Vitamin D and Non-Hodgkin Lymphoma Risk in Adults: A Review , 2009, Cancer investigation.

[12]  G. Huynh-Ba,et al.  Gene expression profile of osseointegration of a hydrophilic compared with a hydrophobic microrough implant surface. , 2011, Clinical oral implants research.

[13]  J. Ryu,et al.  Biological responses in osteoblast-like cell line according to thin layer hydroxyapatite coatings on anodized titanium. , 2006, Journal of oral rehabilitation.

[14]  N. Donos,et al.  Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. , 2009, Bone.

[15]  G. Gibson,et al.  Identification and immunolocalization of type X collagen at the ligament-bone interface. , 1996, Biochemical and biophysical research communications.

[16]  S. Roberts,et al.  Type X collagen in the human invertebral disc: an indication of repair or remodelling? , 1998, The Histochemical Journal.

[17]  J. Lausmaa,et al.  Titanium oral implants: surface characteristics, interface biology and clinical outcome , 2010, Journal of The Royal Society Interface.

[18]  J. Reseland,et al.  Identification of Early Response Genes to Roughness and Fluoride Modification of Titanium Implants in Human Osteoblasts , 2012, Implant dentistry.

[19]  I. Nishimura,et al.  The role of titanium implant surface modification with hydroxyapatite nanoparticles in progressive early bone-implant fixation in vivo. , 2009, The International journal of oral & maxillofacial implants.

[20]  P. Branemark,et al.  Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. , 1977, Scandinavian journal of plastic and reconstructive surgery. Supplementum.

[21]  F. Butz,et al.  Harder and Stiffer Bone Osseointegrated to Roughened Titanium , 2006, Journal of dental research.

[22]  B D Boyan,et al.  Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. , 2004, Journal of biomedical materials research. Part A.

[23]  C. Lengner,et al.  Networks and hubs for the transcriptional control of osteoblastogenesis , 2006, Reviews in Endocrine and Metabolic Disorders.

[24]  Y. Hishikawa,et al.  Enhanced osseointegration by the chemotactic activity of plasma fibronectin for cellular fibronectin positive cells. , 2007, Biomaterials.

[25]  D. Cochran,et al.  State of the science on implant dentistry: a workshop developed using an evidence-based approach. , 2007, The International journal of oral & maxillofacial implants.

[26]  I. Zhulin,et al.  PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light , 1999, Microbiology and Molecular Biology Reviews.

[27]  L. Gerstenfeld,et al.  Transient Chondrogenic Phase in the Intramembranous Pathway During Normal Skeletal Development , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  Yoshinobu Tanaka,et al.  High-throughput gene expression analysis in bone healing around titanium implants by DNA microarray. , 2008, Clinical oral implants research.

[29]  Janet Moradian-Oldak,et al.  Tissue engineering strategies for the future generation of dental implants. , 2006, Periodontology 2000.

[30]  A. Hokugo,et al.  Trabecular Bone Deterioration in col9a1+/− Mice Associated With Enlarged Osteoclasts Adhered to Collagen IX–Deficient Bone , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  G. Watzek,et al.  Impact of dietary vitamin D on osseointegration in the ovariectomized rat. , 2012, Clinical oral implants research.

[32]  S. Volinia,et al.  Analysis of osteoblast-like MG63 cells' response to a rough implant surface by means of DNA microarray. , 2003, The Journal of oral implantology.

[33]  J. Gimble,et al.  Circadian Rhythm of Osteocalcin in the Maxillomandibular Complex , 2009, Journal of dentistry research.

[34]  H. Malling,et al.  CXC chemokine receptor 4 expression and stromal cell‐derived factor‐1α‐induced chemotaxis in CD4+ T lymphocytes are regulated by interleukin‐4 and
interleukin‐10 , 2000, Immunology.

[35]  Richard Skalak,et al.  The interface zone of inorganic implantsIn vivo: Titanium implants in bone , 2006, Annals of Biomedical Engineering.

[36]  A. Wennerberg,et al.  Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties , 2012, Journal of dental research.

[37]  J. Mulvihill,et al.  Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta. , 2006, The New England journal of medicine.

[38]  Nadr M Jomha,et al.  Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells , 2012, Stem Cell Research & Therapy.

[39]  J. Ryu,et al.  Effect of various implant coatings on biological responses in MG63 using cDNA microarray. , 2006, Journal of oral rehabilitation.

[40]  C. Galli,et al.  The importance of WNT pathways for bone metabolism and their regulation by implant topography. , 2012, European cells & materials.

[41]  Yang Yang,et al.  Osteoblasts Generate Harder, Stiffer, and More Delamination‐Resistant Mineralized Tissue on Titanium Than on Polystyrene, Associated With Distinct Tissue Micro‐ and Ultrastructure , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  P. Branemark.  Osseointegration and its experimental background. , 1983, The Journal of prosthetic dentistry.

[43]  R. Katz,et al.  The first-choice standard of care for an edentulous mandible: a Delphi method survey of academic prosthodontists in the United States. , 2012, Journal of the American Dental Association.

[44]  I. Nishimura,et al.  Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model. , 2009, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[45]  F. Rahemtulla,et al.  Proteoglycans at the bone-implant interface. , 1998, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[46]  I. Nishimura,et al.  Altered cartilage phenotype expressed during intramembranous bone formation , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  S. Volinia,et al.  Analysis of MG63 osteoblastic-cell response to a new nanoporous implant surface by means of a microarray technology. , 2004, Clinical oral implants research.

[48]  C. Colwell,et al.  Circadian Rhythm and Cartilage Extracellular Matrix Genes in Osseointegration: A Genome-Wide Screening of Implant Failure by Vitamin D Deficiency , 2011, PloS one.

[49]  Farshid Guilak,et al.  Circadian Oscillation of Gene Expression in Murine Calvarial Bone , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  B. Olsen,et al.  A short isoform of Col9a1 supports alveolar bone repair. , 1999, The American journal of pathology.

[51]  Yuhong Huang,et al.  Discrete deposition of hydroxyapatite nanoparticles on a titanium implant with predisposing substrate microtopography accelerated osseointegration , 2007 .

[52]  I. Nishimura,et al.  Genes Differentially Expressed in Titanium Implant Healing , 2006, Journal of dental research.

[53]  U. Nannmark,et al.  Integrin and chemokine receptor gene expression in implant-adherent cells during early osseointegration , 2010, Journal of materials science. Materials in medicine.

[54]  C. Gretzer,et al.  Comparative molecular assessment of early osseointegration in implant-adherent cells. , 2013, Bone.

[55]  G O Gallucci,et al.  Success Criteria in Implant Dentistry , 2012, Journal of dental research.

[56]  B. Caterson,et al.  Type X collagen is colocalized with a proteoglycan epitope to form distinct morphological structures in bovine growth cartilage. , 1996, Bone.

[57]  L F Cooper,et al.  Biologic determinants of bone formation for osseointegration: clues for future clinical improvements. , 1998, The Journal of prosthetic dentistry.

[58]  S. Silvestros,et al.  Analysis of osteoblastic gene expression in the early human mesenchymal cell response to a chemically modified implant surface: an in vitro study. , 2011, Clinical oral implants research.

[59]  Ronald Jung,et al.  A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years. , 2012, Clinical oral implants research.