Disruption in Ovarian Cyclicity Due to 2‐Bromopropane in the Rat

In 1995, a cluster of patients with amenorrhea, oligospermia and anemia were found among South Korean workers exposed to 2-bromopropane which was used as an alternative to ozone layer-depleting freon 1). Neither reproductive nor hematopoietic toxicity of 2-bromopropane had been reported before that. Thus, animal experiments were conducted to clarify its toxicity on the reproductive and hematopoietic system. Our previous study revealed that 2-bromopropane impaired spermatogenesis and hematopoiesis dose-dependently in male rats2' 3). However, its toxicity on female reproductive function has remained to be elucidated. In this study, we aimed to clarify the effects of 2bromopropane on estrous cycles in female rats.