Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)

Summary.  Background:  Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies against coagulation factor VIII and characterized by spontaneous hemorrhage in patients with no previous family or personal history of bleeding. Although data on several AHA cohorts have been collected, limited information is available on the optimal management of AHA.

J. Esser | G. Tiscia | M. N. D. Minno | G. Gaidano | E. Grandone | G. Mariani | V. Jiménez‐Yuste | M. Morfini | E. Santagostino | M. Franchini | C. Rothschild | S. Testa | A. Falanga | O. Paoletti | W. Korte | P. Kamphuisen | Y. Gruel | F. Pellegrini | C. Santoro | G. Barillari | G. Evans | M. Marietta | P. Pedrazzi | P. Knöbl | N. Schleinitz | H. Lévesque | R. Santoro | S. Pasca | E. Zanon | A. Tagliaferri | M. Mancuso | S. Pavord | P. Collins | C. Altisent | A. Mäkipernaa | G. Rivolta | G. Minno | R. Schutgens | S. Rangarajan | K. Holstein | M. Mazzucconi | A. Tiede | M. E. Mingot | P. Schinco | G. Tagariello | R. Sartori | B. Gorkom | S. Linari | L. Nemes | C. D. Perna | A. Cerbone | R. P. Garrido | L. Tengborn | J. Peynet | P. Beurrier | V. Guérin | J. Ninet | D. Imberti | F. Boehlen | A. Squizzato | J. Wilde | T. Quéméneur | P. Ypma | L. Darnige | G. Gamba | A. Scortechini | R. Landolfi | E. Pogliani | R. Paolini | P. Gautier | S. Bellucci | S. Siragusa | A. Giebl | M. Carpenedo | S. Girault | F. Leebeek | G. Radványi | Á. Schlammadinger | A. Borchiellini | P. Chowdary | T. Lerede | R. Campo | F. Lifermann | P. Marco | R. Poggio | R. Loreth | V. Toschi | M. Sigaud | F. Baudo | T. Caimi | G. Theodossiades | R. Boullosa | R. Marlu | F. Baghaei | P. Knoebl | L. Contino | S. Voisin | N. Hézard | L. Gennaro | A. Rodríguez-Huerta | G. Sottilotta | J. Devignes | M. Lapecorella | L. Novarese | M. Khellaf | C. Sedano | N. Bermejo | A. Huth‐Kühne | G. Piseddu | M. Heistinger | L. D. Paoli | C. Remiddi | M. Koenig | S. Trouillier | S. Moratelli | A. Aouba | M. Campos | F. Valeri | B. Brandolini | Fabio Pellegrini | A. Maggioni | R. d’Oiron | P. Collins | Carolina Aguilar | Alfonso Iorio | G. Papaleo | I. Novakova | M. Girotto | U. Steigerwald | M. D'inca | R. Ghirardi | K. Hamulyák | M. J. G. Pimentel | G. Aspoek | H. André | Hannes Borg | D. Tasca | N. Marten | P. W. V. D. Linden | J. V. D. Meer | M. F. Arguelles | L. Jose-Felix | M. Pascual | Nz Perez Gonzale | M. P. Garcia | A. Munoz | Each Registry Contributors

[1]  P. Collins,et al.  Management of acquired haemophilia A , 2011, Journal of thrombosis and haemostasis : JTH.

[2]  C. Kessler,et al.  Acquired Inhibitors to Factor VIII , 2010 .

[3]  C. Kessler,et al.  Consensus recommendations for the diagnosis and treatment of acquired hemophilia A , 2010, BMC Research Notes.

[4]  V. Toschi,et al.  Diagnosis, laboratory aspects and management of acquired hemophilia A , 2010, Internal and emergency medicine.

[5]  J. Oldenburg,et al.  Immunoadsorption in the treatment of acquired haemophilia. , 2009, Atherosclerosis. Supplements.

[6]  S. Bent,et al.  The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis , 2009, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[7]  C. Kessler,et al.  International recommendations on the diagnosis and treatment of patients with acquired hemophilia A , 2009, Haematologica.

[8]  G. Lippi,et al.  Extracorporeal Immunoadsorption for the Treatment of Coagulation Inhibitors , 2009, Seminars in thrombosis and hemostasis.

[9]  L. Alberio,et al.  Immunosuppressive treatment for acquired haemophilia: current practice and future directions in Germany, Austria and Switzerland , 2009, Annals of Hematology.

[10]  G. Lippi,et al.  Laboratory, clinical and therapeutic aspects of acquired hemophilia A. , 2008, Clinica chimica acta; international journal of clinical chemistry.

[11]  G. Lippi,et al.  Acquired factor VIII inhibitors. , 2008, Blood.

[12]  S. Seremetis,et al.  Treatment of acquired haemophilia with recombinant activated FVII: a critical appraisal , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[13]  T. Baglin,et al.  Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation. , 2007, Blood.

[14]  H. Vetter,et al.  Treatment of acquired hemophilia by the Bonn-Malmo Protocol: documentation of an in vivo immunomodulating concept. , 2005, Blood.

[15]  L. Boggio,et al.  Rituximab for autoimmune haemophilia: a proposed treatment algorithm , 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

[16]  J. Delgado,et al.  Acquired Haemophilia: Review and Meta‐Analysis Focused on Therapy and Prognostic Factors , 2003, British journal of haematology.

[17]  E. Lian,et al.  Aquired factor VIII inhibitor treated with cyclophosphamide, vincristine, and prednisone , 2002, American journal of hematology.

[18]  E. Pitlik,et al.  New protocol for immune tolerance induction in acquired hemophilia. , 2000, Haematologica.

[19]  C. Hay.  1 Acquired haemophilia , 1998 .

[20]  J. Ducobu,et al.  Low response to high‐dose intravenous immunoglobulin in the treatment of acquired factor VIII inhibitor , 1996, British journal of haematology.

[21]  C. Kessler,et al.  9 Acquired inhibitors , 1996 .

[22]  C. Kessler,et al.  Acquired inhibitors. , 1996, Bailliere's clinical haematology.

[23]  C. Kessler,et al.  A prospective study of treatment of acquired (autoimmune) factor VIII inhibitors with high-dose intravenous gammaglobulin. , 1995, Blood.

[24]  M. van den Berg,et al.  The Nijmegen Modification of the Bethesda Assay for Factor VIII:C Inhibitors: Improved Specificity and Reliability , 1995, Thrombosis and Haemostasis.

[25]  C. Kessler,et al.  Use of porcine factor VIII in the treatment of patients with acquired hemophilia. , 1993, Blood.

[26]  S. Mehta,et al.  Acquired haemophilia. , 1990, The Journal of the Association of Physicians of India.

[27]  A. Y. Chiu,et al.  Combination immunosuppressive therapy after factor VIII infusion for acquired factor VIII inhibitor. , 1989, Annals of internal medicine.

[28]  M. Kazatchkine,et al.  ANTI-IDIOTYPIC SUPPRESSION OF AUTOANTIBODIES TO FACTOR VIII (ANTIHAEMOPHILIC FACTOR) BY HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN , 1984, The Lancet.

[29]  L. Hoyer,et al.  Inactivation of factor VIII coagulant activity by two different types of human antibodies. , 1982, Blood.

[30]  K. Lechner,et al.  A Survey of 215 Non-Hemophilic Patients with Inhibitors to Factor VIII , 1981, Thrombosis and Haemostasis.

[31]  D. Green,et al.  Proceedings: A more uniform measurement of factor VIII inhibitors. , 1975, Thrombosis et diathesis haemorrhagica.