Focal stimulation of the thalamic reticular nucleus induces focal gamma waves in cortex.

Electrical stimulation of the thalamic reticular nucleus (TRN; 0.5-s trains of 500-Hz 0.5-ms pulses at 5-10 microA) evokes focal oscillations of cortical electrical potentials in the gamma frequency band ( approximately 35-55 Hz). These evoked oscillations are specific to either the somatosensory or auditory cortex and to subregions of the cortical receptotopic map, depending on what part of the TRN is stimulated. Focal stimulation of the internal capsule, however, evokes focal slow potentials, without gamma activity. Our results suggest that the TRN's role extends beyond that of general cortical arousal to include specific modality and submodality activation of the forebrain.

[1]  W. Singer,et al.  Role of Reticular Activation in the Modulation of Intracortical Synchronization , 1996, Science.

[2]  W. Freeman,et al.  Spatial patterns of visual cortical fast EEG during conditioned reflex in a rhesus monkey , 1987, Brain Research.

[3]  D. Barth,et al.  Thalamic modulation of high-frequency oscillating potentials in auditory cortex , 1996, Nature.

[4]  J. Crabtree.  Organization in the somatosensory sector of the cat's thalamic reticular nucleus , 1996, The Journal of comparative neurology.

[5]  A. Scheibel,et al.  Specialized organizational patterns within the nucleus reticularis thalami of the cat. , 1972, Experimental neurology.

[6]  A. Scheibel,et al.  The organization of the nucleus reticularis thalami: a Golgi study. , 1966, Brain research.

[7]  M. Steriade,et al.  Reticularis thalami neurons revisited: activity changes during shifts in states of vigilance , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[8]  R. W. Guillery,et al.  Retinotopic organization within the thalamic reticular nucleus demonstrated by a double label autoradiographic technique , 1977, Brain Research.

[9]  D. Contreras,et al.  Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  P. Ohara,et al.  The thalamic reticular nucleus of the adult rat: experimental anatomical studies , 1985, Journal of neurocytology.

[11]  Rose Je.  The cortical connections of the reticular complex of the thalamus. , 1952, Research publications - Association for Research in Nervous and Mental Disease.

[12]  C. Gray,et al.  Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex , 1996, Science.

[13]  K. Chow.  Regional degeneration of the thalamic reticular nucleus following cortical ablations in monkeys , 1952, The Journal of comparative neurology.

[14]  D. Pinault,et al.  Control of 40-Hz * firing of reticular thalamic cells by neurotransmitters , 1992, Neuroscience.

[15]  R. Llinás,et al.  The functional states of the thalamus and the associated neuronal interplay. , 1988, Physiological reviews.

[16]  W. Cowan,et al.  CORTICAL CONNEXIONS OF THE THALAMIC RETICULAR NUCLEUS. , 1964, Journal of anatomy.

[17]  E. G. Jones,et al.  Some aspects of the organization of the thalamic reticular complex , 2004, The Journal of comparative neurology.

[18]  D. Contreras,et al.  Synchronization of fast (30-40 Hz) spontaneous oscillations in intrathalamic and thalamocortical networks , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  W. Singer,et al.  Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Connors,et al.  Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. , 1991, Science.

[21]  M. Steriade,et al.  Voltage-dependent fast (20–40 Hz) oscillations in long-axoned neocortical neurons , 1992, Neuroscience.

[22]  Diego Minciacchi,et al.  Thalamic Networks for Relay and Modulation , 1993 .

[23]  T. Bullock,et al.  Induced Rhythms in the Brain , 1992, Brain Dynamics.

[24]  F. Crick.  Function of the thalamic reticular complex: the searchlight hypothesis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[25]  A. Parent,et al.  Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei , 1988, Neuroscience.

[26]  M. Conley,et al.  The Organization of Projections from Subdivisions of the Auditory Cortex and Thalamus to the Auditory Sector of the Thalamic Reticular Nucleus in Galago , 1991, The European journal of neuroscience.

[27]  R. Llinás,et al.  In vitro neurons in mammalian cortical layer 4 exhibit intrinsic oscillatory activity in the 10- to 50-Hz frequency range. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[28]  E. Fetz,et al.  Oscillatory activity in sensorimotor cortex of awake monkeys: synchronization of local field potentials and relation to behavior. , 1996, Journal of neurophysiology.

[29]  G. Buzsáki,et al.  Interneurons of the hippocampus , 1998, Hippocampus.