Immunoglobulin- and hepatitis B surface antigen-specific circulating immune complexes in chronic hepatitis B virus infection.

For assessing the role of circulating immune complexes (CIC) in chronic hepatitis B virus (HBV) infection, CICs containing IgM, IgG, and HBsAg were determined by C1q and conglutinin (K) assays in 216 patients with chronic HBV infection and 54 healthy controls. The concentration of each type of CIC in patients is higher than in controls (P = 0.0001). CIC is a common feature of chronic HBV infection with 95.8% of cases having at least one abnormal test result. At least one type of HBsAg-CIC is positive in 54.2% of patients. HBsAg-CIC positivity is associated with HBeAg positivity (P = 0.0001), higher aminotransferase levels (P < 0.002), and younger age (P = 0.001). IgG-CIC or IgM-HBsAg-CIC correlates with higher aminotransferase activity (P = 0.001). In conclusion, HBsAg-CIC correlates with HBV replication. IgG-CIC and/or IgM-HBsAg-CIC correlate with disease activity. Immune-mediated injury may play a role in the pathogenesis of chronic HBV infection.

[1]  J. Tsai,et al.  Serum alanine aminotransferase level in relation to hepatitis B and C virus infections among blood donors. , 2008, Liver.

[2]  H. Margolis,et al.  Hepatitis B surface antigen- and immunoglobulin-specific circulating immune complexes in acute hepatitis B virus infection. , 1996, Clinical immunology and immunopathology.

[3]  H. Margolis,et al.  Increased IgM class circulating immune complexes in acute hepatitis A virus infection. , 1996, Clinical immunology and immunopathology.

[4]  O. Lortholary,et al.  Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. , 1996, Medicine.

[5]  J. Tsai,et al.  Clinical evaluation of serum alpha-fetoprotein and circulating immune complexes as tumour markers of hepatocellular carcinoma. , 1995, British Journal of Cancer.

[6]  J. Tsai,et al.  Circulating immune complexes in chronic hepatitis C , 1995, Journal of medical virology.

[7]  J. Tsai,et al.  Increased IgM‐Containing Circulating Immune Complexes in Patients Co‐infected with Hepatitis C and Hepatitis B , 1995, Medicine.

[8]  H. Margolis,et al.  Circulating immune complexes in chronic hepatitis related to hepatitis C and B viruses infection. , 1995, Clinical immunology and immunopathology.

[9]  F. Chisari,et al.  Hepatitis B virus immunopathogenesis. , 1995, Annual review of immunology.

[10]  J. Tsai,et al.  Hepatitis B and C virus infection as risk factors for liver cirrhosis and cirrhotic hepatocellular carcinoma: a case-control study. , 2008, Liver.

[11]  J. Tsai,et al.  Hepatitis C virus infection as a risk factor for non‐alcoholic liver cirrhosis in taiwan , 1993, Journal of medical virology.

[12]  J. Stránský,et al.  Clinical importance of assessment of HBsAg/IgM complexes in chronic hepatitis B. , 1993, Acta virologica.

[13]  F. Zoulim,et al.  Diagnostic markers of viral hepatitis B and C. , 1993, Gut.

[14]  J. Tsai,et al.  Elevation of circulating immune complexes and its relationship to alpha-fetoprotein levels in patients with hepatitis B surface antigen-positive hepatocellular carcinoma. , 1991, Cancer investigation.

[15]  R. Palmiter,et al.  Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. , 1990, Science.

[16]  H. Margolis,et al.  Immunoglobulin and hepatitis B surface antigen‐specific circulating immune complexes in chronic hepatitis with hepatitis delta virus infection , 1990, Journal of Medical Virology.

[17]  H. Margolis,et al.  Characteristics of chemically aggregated IgM in an immunoglobulin class-specific immune complex assay. , 1987, Journal of immunological methods.

[18]  R. Veerhuis,et al.  Difference in clearance kinetics of particulate immune complexes and soluble aggregates of IgG in vivo. , 1986, Clinical immunology and immunopathology.

[19]  D. Sansonno,et al.  Autoantibody to albumin of type G and M in acute and chronic viral hepatitis. , 1986, Hepato-gastroenterology.

[20]  F. Hollinger,et al.  Detection of an IgM antiidiotype directed against anti‐HBs in hepatitis B patients , 1985, Hepatology.

[21]  E. Celis,et al.  HBsAg‐Serum Protein Complexes Stimulate Immune T Lymphocytes More Efficiently Than Do Pure HBsAg , 1984, Hepatology.

[22]  F. Iber Hepatology: A Textbook of Liver Disease , 1983 .

[23]  C R Howard,et al.  Chronic liver disease: the detection and characterization of circulating immune complexes. , 1983, Immunology.

[24]  P. Casali,et al.  Immune complexes in viral infection. , 1983, Current topics in microbiology and immunology.

[25]  V. Jones,et al.  Isolation of immune complexes and characterisation of their constituent antigens and antibodies in some human diseases: a review. , 1981, Journal of immunological methods.

[26]  M. Devey,et al.  Measurement of antigen-antibody complexes in mouse sera by conglutinin, C1q and rheumatoid factor solid phase binding assays. , 1980, Journal of immunological methods.

[27]  C. Abrass,et al.  Non-specificity of circulating immune complexes in patients with acute and chronic liver disease. , 1980, Clinical and experimental immunology.

[28]  G. Macdonald,et al.  Complement, lymphocytotoxins and immune complexes in infectious mononucleosis: serial studies in uncomplicated cases. , 1978, Clinical and experimental immunology.

[29]  J. Hoofnagle,et al.  The interaction of rheumatoid factor with hepatitis B surface antigen-antibody complexes. , 1975, Clinical and experimental immunology.

[30]  Fudenberg Hh Letter: Transfer factor. , 1973, Lancet.