Primary and isolated adult T-cell leukemia/lymphoma of the bone marrow.

The distribution of adult T-cell leukemia/lymphoma (ATLL) is typically systemic. In addition to peripheral blood (PB) and lymph nodes, extranodal sites such as the skin, lung, liver, gastrointestinal tract, and central nervous system are frequently involved. We report a unique case of ATLL in which the patient presented with prolonged fever. A 65-year-old man had high-grade fever lasting for 2 weeks. He showed no lymphadenopathy, hepatosplenomegaly, skin lesions, or PB involvement. Bone marrow examination showed widespread infiltration of ATLL cells. (18)F-fluorodeoxy glucose positron emission tomography (FDG-PET) revealed that the disease was confined to the bone marrow.

[1]  J. Rashbass,et al.  Primary and isolated anaplastic large cell lymphoma of the bone marrow , 2005, Leukemia & lymphoma.

[2]  D. Catovsky,et al.  Isolated Bone Marrow Involvement in Diffuse Large B Cell Lymphoma: A Report of Three Cases with Review of Morphological, Immunophenotypic and Cytogenetic Findings , 2004, Leukemia & lymphoma.

[3]  M. Kosaka,et al.  Primary adult T-Cell leukemia/lymphoma of bone , 2004, International journal of hematology.

[4]  R. Yona,et al.  Isolated bone marrow non-Hodgkin's lymphoma. Report of two cases and literature review. , 2003, European journal of internal medicine.

[5]  M. Tomonaga,et al.  A new G‐CSF‐supported combination chemotherapy, LSG15, for adult T‐cell leukaemia‐lymphoma: Japan Clinical Oncology Group Study 9303 , 2001, British journal of haematology.

[6]  Y. Sasaguri,et al.  Adult T-cell leukemia/lymphoma in which the pathohistological diagnosis was identical to that of Ki-1 positive anaplastic large cell lymphoma. , 1999, Internal medicine.

[7]  M. Matsuoka,et al.  Primary adult T cell leukemia of bone: two patients with primary bone lesion showing monoclonal integration of HTLV-I proviral DNA. , 1996, Leukemia.

[8]  M. Ponzoni,et al.  Isolated bone marrow non-Hodgkin's lymphoma: a clinicopathologic study. , 1994, Mayo Clinic proceedings.

[9]  K. Yamaguchi,et al.  Adult T cell leukaemia-lymphoma. , 1993, Bailliere's clinical haematology.

[10]  W. Blattner,et al.  Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. , 1983, The New England journal of medicine.

[11]  A. H. Nagi,et al.  Non-Hodgkin's lymphoma of bone marrow--an unusual presentation. , 1982, JPMA. The Journal of the Pakistan Medical Association.

[12]  J. Barton,et al.  Isolated marrow lymphoma: An entity of possible T‐cell derivation , 1980, Cancer.