ENTRY OF β‐OXALYL‐l‐α,β‐DIAMINOPROPIONIC ACID, THE LATHYRUS SATIVUS NEUROTOXIN INTO THE CENTRAL NERVOUS SYSTEM OF THE ADULT RAT, CHICK AND THE RHESUS MONKEY

Abstract— A comparative study of the tissue disposition of the L. sativus neurotoxin has been done using [3H]0DAP with special reference to the CNS in normal and Diamox treated (acidotic) adult rhesus monkeys and also in the day old chick, a species susceptible to the neurotoxin, and the adult rat which is refractory to it. The neurotoxin was detected in the CNS of the acidotic monkey and also in the normal monkey in nearly the same quantity. The neurotoxin was largely localised in the lumbosacral region of the spinal cord. The amount of radioactive ODAP in the CNS following its intraperitoneal injection was twice that seen following its intravenous injection.

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