Double pituitary adenoma--two case reports.

A 43-year-old male and a 39-year-old male presented with multiple pituitary adenomas with two distinct histological types. The first patient who had multiple endocrine neoplasia type 1 had developed acromegaly due to a growth hormone-releasing hormone (GHRH)-producing pancreatic tumor. Both plasma GHRH and growth hormone (GH) levels decreased to normal after resection of the pancreatic tumor. However, the plasma GH level gradually increased again and magnetic resonance imaging revealed pituitary adenoma formation. Histological examination revealed two different histological types of pituitary adenoma: GH cell adenoma and null cell adenoma. The second patient, with no such genetic condition, had a non-functioning pituitary adenoma. Histological examination revealed two different histological types of silent GH cell adenoma and silent gonadotroph adenoma. Careful histological examination is required to exclude the possibility of multiple pituitary adenomas.

[1]  T. Iwabuchi,et al.  [A plurihormonal adenoma: a case report]. , 1994, No shinkei geka. Neurological surgery.

[2]  B. Scheithauer,et al.  Double adenomas of the pituitary: a clinicopathological study of 11 tumors. , 1992, Neurosurgery.

[3]  K. Yoshimoto,et al.  Allele Loss on Chromosome 11 in a Pituitary Tumor from a Patient with Multiple Endocrine Neoplasia Type 1 , 1991, Japanese journal of cancer research : Gann.

[4]  B. Scheithauer,et al.  Multiple adenomas of the human pituitary. A retrospective autopsy study with clinical implications. , 1991, Journal of neurosurgery.

[5]  K. Kovacs,et al.  Clonal origin of pituitary adenomas. , 1990, The Journal of clinical endocrinology and metabolism.

[6]  R. Martuza,et al.  Clonal origin of pituitary adenomas. , 1990, Journal of neurosurgery.

[7]  C. Larsson,et al.  Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[8]  S T Sweriduk,et al.  Pituitary adenoma. , 1988, American family physician.

[9]  B. Scheithauer,et al.  Plurihormonal pituitary adenomas. , 1986, Seminars in diagnostic pathology.

[10]  K. Kovacs,et al.  Monomorphous plurihormonal adenoma of the human pituitary. A histologic, immunocytologic and ultrastructural study , 1984, Cancer.

[11]  K. Kovacs,et al.  Subclinical adenomas of the human pituitary. New light on old problems. , 1983, Archives of pathology & laboratory medicine.

[12]  B. Scheithauer,et al.  Pituitary adenomas producing growth hormone, prolactin, and one or more glycoprotein hormones: a histologic, immunohistochemical, and ultrastructural study of four surgically removed tumors. , 1983, Ultrastructural pathology.

[13]  R. R. Smith,et al.  Incidental pituitary adenomas. , 1981, Journal of neurosurgery.

[14]  K. Kovacs,et al.  Pituitary adenomas in old age. , 1980, Journal of gerontology.

[15]  P. Heitz.  Multihormonal pituitary adenomas. , 1979, Hormone research.

[16]  G. Tolis,et al.  Acromegaly and galactorrhea-amenorrhea with two pituitary adenomas secreting growth hormone or prolactin. A case report. , 1978, Annals of internal medicine.

[17]  R. Costello.  Subclinical Adenoma of the Pituitary Gland. , 1936, The American journal of pathology.