Teratogenic effects of Ochratoxin A in rats with impaired renal function.

The teratogenic potential of Ochratoxin A (OA), was compared in impaired renal function (IRF) and sham-operated (SO) female rats. Surgical removal of approximately 70% of the total renal tissue was accomplished utilizing unilateral ligation/electrocoagulation procedures. Control animals were sham-operated. All animals were allowed a period of 27 days to recover post surgery. IRF rats exhibited normal mating tendencies and the pregnancy rate was 100%. A single, subcutaneous teratogenic dose of OA (1.75 mg/kg) on gestation day 7 resulted in significantly increased fetal resorptions, decreased fetal body weights and increased fetal malformations in both IRF and SO animals, although the incidence of gross malformations was greater in IRF rats. A subthreshold teratogenic dose (i.e. 1 mg/kg) did not produce any significant increase in embryotoxicity or fetal malformations in IRF animals compared to SO rats.

[1]  A. Hayes,et al.  Teratogenic effects of ochratoxin A in mice. , 1974, Teratology.

[2]  W. Berndt,et al.  Embryocidal, fetotoxic and teratogenic effects of ochratoxin A in rats. , 1982, Toxicology.

[3]  A. Hayes,et al.  Prenatal effects of Ochratoxin A in hamsters. , 1976, Teratology.

[4]  J. Wilson.  Methods for administering agents and detecting malformations in experimental animals , 1965 .

[5]  P. Krogh.  Epidemiology of mycotoxic porcine nephropathy. , 1976, Nordisk veterinaermedicin.

[6]  P. Galtier,et al.  The pharmacokinetic profile of ochratoxin A in the rat after oral and intravenous administration. , 1979, Drug metabolism and disposition: the biological fate of chemicals.

[7]  D. W. Gaylor,et al.  Methods and Concepts of Biometrics Applied to Teratology , 1978 .

[8]  R. Jelínek,et al.  Toxic effects of ochratoxin A and citrinin, alone and in combination, on chicken embryos , 1983, Applied and environmental microbiology.

[9]  J. Newberne,et al.  Accelerated clearing and staining of teratologic specimens by heart and light. , 1970, Teratology.

[10]  P. Scott,et al.  Mycotoxins (ochratoxin A, citrinin, and sterigmatocystin) and toxigenic fungi in grains and other agricultural products. , 1972, Journal of Agricultural and Food Chemistry.

[11]  G. Szczech,et al.  Teratogenic and toxic effects of ochratoxin A in rats. , 1976, Toxicology and applied pharmacology.

[12]  L. Kubena,et al.  Effects of ochratoxin A in the partially nephrectomized rat. , 1984, Journal of toxicology and environmental health.

[13]  R. Hood,et al.  Effects in mice of simultaneous prenatal exposure to ochratoxin A and T-2 toxin. , 1978, Teratology.

[14]  F. Chu.  Studies on ochratoxins. , 1974, CRC critical reviews in toxicology.

[15]  S. Čeović,et al.  Balkan (endemic) nephropathy and foodborn ochratoxin A: preliminary results of a survey of foodstuffs. , 2009, Acta pathologica et microbiologica Scandinavica. Section B, Microbiology.