Enzyme-Responsive Polymers: Classifications, Properties, Synthesis Strategies, and Applications

[1]  A. Ryan.  Azoreductases in drug metabolism , 2017, British journal of pharmacology.

[2]  David J. Lunn,et al.  Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization , 2017, Nature Chemistry.

[3]  Miao-Ping Chien,et al.  Enzyme‐Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction , 2015, Advanced materials.

[4]  C. Schalley,et al.  Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release. , 2015, Chemical communications.

[5]  E. Gillies,et al.  Self‐Immolative Polymers , 2015 .

[6]  Xi Zhang,et al.  Enzyme-responsive polymer assemblies constructed through covalent synthesis and supramolecular strategy. , 2015, Chemical communications.

[7]  Quanyin Hu,et al.  Enzyme-responsive nanomaterials for controlled drug delivery. , 2014, Nanoscale.

[8]  Krzysztof Matyjaszewski,et al.  How are radicals (re)generated in photochemical ATRP? , 2014, Journal of the American Chemical Society.

[9]  Yousef M. Abul-Haija,et al.  Enzyme-responsive hydrogels for biomedical applications , 2014 .

[10]  Roey J. Amir,et al.  Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers. , 2014, Journal of the American Chemical Society.

[11]  Daniel J. Keddie,et al.  A guide to the synthesis of block copolymers using reversible-addition fragmentation chain transfer (RAFT) polymerization. , 2014, Chemical Society reviews.

[12]  Galya Orr,et al.  Enzyme-directed assembly of nanoparticles in tumors monitored by in vivo whole animal imaging and ex vivo super-resolution fluorescence imaging. , 2013, Journal of the American Chemical Society.

[13]  Jizhen Zhang,et al.  Preparation of biodegradable and thermoresponsive enzyme–polymer conjugates with controllable bioactivity via RAFT polymerization , 2013 .

[14]  Rein V. Ulijn,et al.  Enzyme responsive materials: design strategies and future developments. , 2013, Biomaterials science.

[15]  Xi Zhang,et al.  Enzyme-responsive polymeric supra-amphiphiles formed by the complexation of chitosan and ATP. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[16]  Jinming Hu,et al.  Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels. , 2012, Chemical Society reviews.

[17]  Andrew J. Boydston,et al.  Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers , 2012 .

[18]  Molly M Stevens,et al.  Enzyme-responsive nanoparticles for drug release and diagnostics. , 2012, Advanced drug delivery reviews.

[19]  Aoting Qu,et al.  Complex micelles with a responsive shell for controlling of enzymatic degradation , 2012 .

[20]  R. Gemeinhart,et al.  Effects of Molecular Weight and Loading on Matrix Metalloproteinase-2 Mediated Release from Poly(Ethylene Glycol) Diacrylate Hydrogels , 2012, The AAPS Journal.

[21]  Clemens A van Blitterswijk,et al.  Enzyme-catalyzed crosslinkable hydrogels: emerging strategies for tissue engineering. , 2012, Biomaterials.

[22]  T. Baker,et al.  Controlling and switching the morphology of micellar nanoparticles with enzymes. , 2011, Journal of the American Chemical Society.

[23]  Diannan Lu,et al.  A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst. , 2011, Macromolecular rapid communications.

[24]  Dai Fukumura,et al.  Multistage nanoparticle delivery system for deep penetration into tumor tissue , 2011, Proceedings of the National Academy of Sciences.

[25]  Xi Zhang,et al.  An enzyme-responsive polymeric superamphiphile. , 2010, Angewandte Chemie.

[26]  R. Ulijn,et al.  Hydrogels for the detection and management of protease levels. , 2010, Macromolecular bioscience.

[27]  Andrés J. García,et al.  Engineering more than a cell: vascularization strategies in tissue engineering. , 2010, Current opinion in biotechnology.

[28]  Bin Zhao,et al.  Dually responsive aqueous gels from thermo- and light-sensitive hydrophilic ABA triblock copolymers , 2010 .

[29]  U. Sauer,et al.  Systems biology of microbial metabolism. , 2010, Current opinion in microbiology.

[30]  M. Whyte.  Physiological role of alkaline phosphatase explored in hypophosphatasia , 2010, Annals of the New York Academy of Sciences.

[31]  S. Aoshima,et al.  A renaissance in living cationic polymerization. , 2009, Chemical reviews.

[32]  Malar A. Azagarsamy,et al.  Enzyme-triggered disassembly of dendrimer-based amphiphilic nanocontainers. , 2009, Journal of the American Chemical Society.

[33]  Roey J. Amir,et al.  Enzymatically triggered self-assembly of block copolymers. , 2009, Journal of the American Chemical Society.

[34]  H. Börner,et al.  Biotransformation on polymer-peptide conjugates: a versatile tool to trigger microstructure formation. , 2009, Angewandte Chemie.

[35]  Shinji Sakai,et al.  An injectable, in situ enzymatically gellable, gelatin derivative for drug delivery and tissue engineering. , 2009, Biomaterials.

[36]  Krzysztof Matyjaszewski,et al.  Nanostructured functional materials prepared by atom transfer radical polymerization , 2009, Nature Chemistry.

[37]  Tom O. McDonald,et al.  Branched peptide actuators for enzyme responsive hydrogel particles , 2009 .

[38]  M. Stevens,et al.  Enzyme‐Responsive Nanoparticle Systems , 2008 .

[39]  William R. Wagner,et al.  Elastase-Sensitive Elastomeric Scaffolds with Variable Anisotropy for Soft Tissue Engineering , 2008, Pharmaceutical Research.

[40]  R. Ulijn,et al.  Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload. , 2008, Soft matter.

[41]  C. Detrembleur,et al.  In-situ nitroxide-mediated radical polymerization (NMP) processes: their understanding and optimization. , 2008, Chemical reviews.

[42]  A. Metcalfe,et al.  Molecular and Cellular Basis of Regeneration and Tissue Repair , 2007, Cellular and Molecular Life Sciences.

[43]  Matthias P Lutolf,et al.  Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. , 2007, Biomaterials.

[44]  Michiya Matsusaki,et al.  Enzyme-responsive release of encapsulated proteins from biodegradable hollow capsules. , 2006, Biomacromolecules.

[45]  Rein V. Ulijn,et al.  Enzyme-responsive materials: a new class of smart biomaterials , 2006 .

[46]  Bing Xu,et al.  Using a kinase/phosphatase switch to regulate a supramolecular hydrogel and forming the supramolecular hydrogel in vivo. , 2006, Journal of the American Chemical Society.

[47]  G. McConnell,et al.  Enzyme responsive polymer hydrogel beads. , 2005, Chemical communications.

[48]  Yi Yan Yang,et al.  Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. , 2005, Chemical communications.

[49]  H. Gu,et al.  Enzymatic Formation of Supramolecular Hydrogels , 2004 .

[50]  H. Lode,et al.  Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2. , 2004, Journal of the American Chemical Society.

[51]  K. Healy,et al.  Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links. , 2003, Biomacromolecules.

[52]  J. A. Hubbell,et al.  Cell‐Responsive Synthetic Hydrogels , 2003 .

[53]  A. Metters,et al.  Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[54]  T. Allen.  Ligand-targeted therapeutics in anticancer therapy , 2002, Nature Reviews Cancer.

[55]  P. Messersmith,et al.  In situ crosslinking of a biomimetic peptide-PEG hydrogel via thermally triggered activation of factor XIII. , 2002, Biomaterials.

[56]  T. Miyata,et al.  Biomolecule-sensitive hydrogels. , 2002, Advanced drug delivery reviews.

[57]  E. Harth,et al.  New polymer synthesis by nitroxide mediated living radical polymerizations. , 2001, Chemical reviews.

[58]  Wim E. Hennink,et al.  Thermoresponsive Polymeric Micelles with Controlled Instability Based on Hydrolytically Sensitive N-Isopropylacrylamide Copolymers , 2001 .

[59]  A. K. Chatterjee,et al.  LIVING FREE-RADICAL POLYMERIZATION—A REVIEW , 2001 .

[60]  J. Mays,et al.  Living anionic polymerization , 1999 .

[61]  T. Benzinger,et al.  Self-Assembly of Aβ(10-35)-PEG Block Copolymer Fibrils , 1999 .

[62]  A. Tayal,et al.  Rheology and Molecular Weight Changes during Enzymatic Degradation of a Water-Soluble Polymer , 1999 .

[63]  K. Matyjaszewski,et al.  ATOM TRANSFER RADICAL POLYMERIZATION AND THE SYNTHESIS OF POLYMERIC MATERIALS , 1998 .

[64]  J. Chiefari,et al.  Living free-radical polymerization by reversible addition - Fragmentation chain transfer: The RAFT process , 1998 .

[65]  L. Griffith,et al.  Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels , 1997 .

[66]  Nobuhiko Yui,et al.  Double‐stimuli‐responsive degradable hydrogels: interpenetrating polymer networks consisting of gelatin and dextran with different phase separation , 1996 .

[67]  R. Ulijn,et al.  Enzyme-responsive polymers: properties, synthesis and applications , 2014 .

[68]  Allan S Hoffman,et al.  Stimuli-responsive polymers: biomedical applications and challenges for clinical translation. , 2013, Advanced drug delivery reviews.

[69]  K. Landfester,et al.  Enzymatically degradable nanogels by inverse miniemulsion copolymerization of acrylamide with dextran methacrylates as crosslinkers , 2012 .

[70]  M. Ouchi,et al.  Nitroxide-Mediated Polymerization , 2012 .

[71]  R. Ulijn,et al.  Exploiting biocatalysis in peptide self‐assembly , 2010, Biopolymers.

[72]  Jeffrey A. Hubbell,et al.  Polymeric biomaterials with degradation sites for proteases involved in cell migration , 1999 .

[73]  N. Yui,et al.  Double-stimuli-responsive degradation of hydrogels consisting of oligopeptide-terminated poly(ethylene glycol) and dextran with an interpenetrating polymer network. , 1997, Journal of biomaterials science. Polymer edition.

[74]  J. Finlayson,et al.  The ɛ-(γ-Glutamyl)Lysine Crosslink and the Catalytic Role of Transglutaminases , 1977 .

[75]  O. Wichterle,et al.  Hydrophilic Gels for Biological Use , 1960, Nature.