Gastric secretion does not affect the reliability of the 13C‐acetate breath test: A validation of the 13C‐acetate breath test by magnetic resonance imaging

Background  13C‐Acetate labeled meals are widely used to determine meal emptying by means of analyzing resulting 13CO2 exhalation dynamics. In contrast to the underlying metabolic processes, only few 13C breath test meal emptying studies have focused on intragastric processes that may alter 13CO2 exhalation. This work assessed the effect of enhanced gastric secretion on the reliability of half emptying time (t50) measurements by 13C‐acetate breath test.

[1]  C. Prinz,et al.  Do We Need Gastric Acid? , 2008, Digestion.

[2]  D. Menne,et al.  Measuring the interaction of meal and gastric secretion: a combined quantitative magnetic resonance imaging and pharmacokinetic modeling approach , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[3]  R. Liddle,et al.  Regulation of gastric emptying in humans by cholecystokinin. , 1986, The Journal of clinical investigation.

[4]  C. Beglinger,et al.  Gastric emptying of liquid meals measured noninvasively in humans with [13C]Acetate breath test , 1994, Digestive Diseases and Sciences.

[5]  G. Schwartz,et al.  Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. , 1978, The Journal of pediatrics.

[6]  M. Sanaka,et al.  Retention, Fixation, and Loss of the [13C] Label: A Review for the Understanding of Gastric Emptying Breath Tests , 2008, Digestive Diseases and Sciences.

[7]  J. Rehfeld,et al.  Radioimmunoassay of cholecystokinin in human plasma. , 1981, Clinica chimica acta; international journal of clinical chemistry.

[8]  L. Marciani,et al.  Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[9]  P. Boesiger,et al.  Fast and optimized T1 mapping technique for the noninvasive quantification of gastric secretion , 2008, Journal of magnetic resonance imaging : JMRI.

[10]  J. N. Hunt,et al.  Effect of gastrin II on gastric emptying and secretion during a test meal , 1967, British medical journal.

[11]  M. Fox,et al.  Effects of postgastric 13C‐acetate processing on measurement of gastric emptying: a systematic investigation in health , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[12]  P. Boesiger,et al.  Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide , 1997, Gut.

[13]  Peter Boesiger,et al.  Optimized and combined T1 and B1 mapping technique for fast and accurate T1 quantification in contrast‐enhanced abdominal MRI , 2007, Magnetic resonance in medicine.

[14]  M. Singer,et al.  Reliability of the [13C]‐acetate breath test in the measurement of gastric emptying of ethanol solutions: a methodological study , 2004, Scandinavian journal of gastroenterology.

[15]  Lamers,et al.  Effect of gastrin on proximal gastric motor function in humans , 1999, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[16]  J. Borovička,et al.  Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans. , 1996, The American journal of physiology.

[17]  Michael Camilleri,et al.  Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test , 2000, American Journal of Gastroenterology.

[18]  A. Zinsmeister,et al.  [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. , 1997, Gastroenterology.

[19]  V. Carey,et al.  Mixed-Effects Models in S and S-Plus , 2001 .

[20]  P. Holzer.  Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tract. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[21]  P. Boesiger,et al.  The effect of gastric secretion on gastric physiology and emptying in the fasted and fed state assessed by magnetic resonance imaging , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[22]  B. Braden,et al.  The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. , 1995, Gastroenterology.

[23]  L. Marciani,et al.  Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[24]  E. Ravussin,et al.  Substrate utilization during prolonged exercise after ingestion of 13C-glucose in obese and control subjects. , 1980, International journal of obesity.

[25]  P. Rutgeerts,et al.  Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. , 1993, Gastroenterology.

[26]  B. Braden,et al.  13C-breath tests: current state of the art and future directions. , 2007, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[27]  C. Beglinger,et al.  Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. , 1991, Gastroenterology.

[28]  O. Olsen,et al.  Concentrations of Secretin and CCK in Plasma and Pancreatico‐biliary Secretion in Response to Intraduodenal Acid and Fat , 1986, Pancreas.

[29]  L. Sidossis,et al.  Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies. , 1995, The Journal of clinical investigation.

[30]  M. Camilleri,et al.  Influence of clinical parameters on the results of 13C‐octanoic acid breath tests: examination of different mathematical models in a large patient cohort , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[31]  D. Johnston,et al.  Use of pentagastrin in a test of gastric acid secretion. , 1967, Lancet.

[32]  Xh Huang,et al.  Pharmacokinetic-Pharmacodynamic Modeling and Simulation. , 2007 .

[33]  Recent advances in the interpretation of the (13)C octanoate breath test for gastric emptying. , 2009, Journal of breath research.

[34]  Michael Camilleri,et al.  Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test. , 2000 .

[35]  L. Sidossis,et al.  A new correction factor for use in tracer estimations of plasma fatty acid oxidation. , 1995, The American journal of physiology.