Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise

[1]  M. Riva,et al.  Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype. , 2022, Developmental psychobiology.

[2]  M. Buuse,et al.  BDNF Val66Met genotype and adolescent glucocorticoid treatment induce sex-specific disruptions to fear extinction and amygdala GABAergic interneuron expression in mice , 2022, Hormones and Behavior.

[3]  M. Riva,et al.  Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory , 2022, Translational Psychiatry.

[4]  Z. Petrovic,et al.  Sex‐specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive‐like behavior in mice , 2022, Journal of neuroscience research.

[5]  R. Ito,et al.  The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands , 2022, Neuroscience & Biobehavioral Reviews.

[6]  R. Richardson,et al.  Fear extinction learning and retention during adolescence in rats and mice: A systematic review , 2021, Neuroscience & Biobehavioral Reviews.

[7]  Jeiwon Cho,et al.  SGK1 knockdown in the medial prefrontal cortex reduces resistance to stress-induced memory impairment , 2021, European Neuropsychopharmacology.

[8]  K. Steece-Collier,et al.  The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats , 2020, Neurobiology of Disease.

[9]  C. Dickey,et al.  FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism , 2020, Brain, behavior, & immunity - health.

[10]  S. Arent,et al.  The Effects of Exercise on Anxiety and Depression , 2020, Handbook of Sport Psychology.

[11]  M. Riva,et al.  Sex Differences in the Enduring Effects of Social Deprivation during Adolescence in Rats: Implications for Psychiatric Disorders , 2020, Neuroscience.

[12]  Nu-Chu Liang,et al.  Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats , 2020, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

[13]  M. van den Buuse,et al.  Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders , 2020, Molecular Psychiatry.

[14]  M. Baratta,et al.  Sex differences in resilience: Experiential factors and their mechanisms , 2019, The European journal of neuroscience.

[15]  R. Bryant,et al.  The capacity for acute exercise to modulate emotional memories: A review of findings and mechanisms , 2019, Neuroscience & Biobehavioral Reviews.

[16]  R. Richardson,et al.  Timing is everything: Developmental differences in the effect of chronic corticosterone exposure on extinction retention. , 2019, Behavioral neuroscience.

[17]  R. Bryant,et al.  Acute exercise-induced enhancement of fear inhibition is moderated by BDNF Val66Met polymorphism , 2019, Translational Psychiatry.

[18]  S. Southwick,et al.  BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise , 2019, Psychoneuroendocrinology.

[19]  M. van den Buuse,et al.  Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation , 2018, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[20]  Y. Okamoto,et al.  Combined brain‐derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post‐traumatic stress disorder , 2018, Genes, brain, and behavior.

[21]  P. Lucassen,et al.  Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm , 2018, Learning & memory.

[22]  R. Marek,et al.  Neural circuits for a top-down control of fear and extinction , 2018, Psychopharmacology.

[23]  C. Liston,et al.  The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior , 2018, Neuron.

[24]  M. Papp,et al.  Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone , 2018, The international journal of neuropsychopharmacology.

[25]  S. Tsai Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders , 2018, Front. Mol. Neurosci..

[26]  Matthew A. Palmer,et al.  The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning , 2018, Psychoneuroendocrinology.

[27]  V. Lessmann,et al.  The Relation Between Long-Term Synaptic Plasticity at Glutamatergic Synapses in the Amygdala and Fear Learning in Adult Heterozygous BDNF-Knockout Mice , 2018, Cerebral cortex.

[28]  B. Greenwood,et al.  Running from fear: Exercise modulation of fear extinction , 2018, Neurobiology of Learning and Memory.

[29]  K. Anstey,et al.  Sex Differences in the Impact of BDNF Genotype on the Longitudinal Relationship between Physical Activity and Cognitive Performance , 2018, Gerontology.

[30]  G. Rosoklija,et al.  Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide , 2017, bioRxiv.

[31]  W. Yung,et al.  BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors , 2017, Front. Cell. Neurosci..

[32]  Y. Forsell,et al.  BDNF Val66Met and childhood adversity on response to physical exercise and internet-based cognitive behavioural therapy in depressed Swedish adults. , 2017, Journal of psychiatric research.

[33]  J. Gogos,et al.  The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair , 2017, Translational Psychiatry.

[34]  N. Herrmann,et al.  The effect of acute exercise on blood concentrations of brain‐derived neurotrophic factor in healthy adults: a meta‐analysis , 2017, The European journal of neuroscience.

[35]  R. Bryant,et al.  Role of BDNF val66met polymorphism in modulating exercised-induced emotional memories , 2017, Psychoneuroendocrinology.

[36]  A. Bandegi,et al.  Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis – related proteins in a rat model of post-traumatic stress disorder , 2017, Neurobiology of Learning and Memory.

[37]  F. Lee,et al.  Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice , 2016, Neuropsychopharmacology.

[38]  K. Martinowich,et al.  Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation , 2016, Translational psychiatry.

[39]  C. Brayne,et al.  A systematic review of reviews on the prevalence of anxiety disorders in adult populations , 2016, Brain and behavior.

[40]  J. Gogos,et al.  BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling , 2015, Molecular Psychiatry.

[41]  J. Medina,et al.  Requirement for BDNF in the Reconsolidation of Fear Extinction , 2015, The Journal of Neuroscience.

[42]  Mark B. Powers,et al.  Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data , 2015, Cognitive behaviour therapy.

[43]  K. Bath,et al.  BDNF Modulates Contextual Fear Learning during Adolescence , 2014, Developmental Neuroscience.

[44]  X. Ni,et al.  Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats , 2014, Neuroscience Letters.

[45]  P. Pauli,et al.  The BDNF Val66Met Polymorphism Modulates the Generalization of Cued Fear Responses to a Novel Context , 2014, Neuropsychopharmacology.

[46]  G. Quirk,et al.  Hippocampal–Prefrontal BDNF and Memory for Fear Extinction , 2014, Neuropsychopharmacology.

[47]  A. Reichelt,et al.  A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation , 2014, Learning & memory.

[48]  Young Hoon Kim,et al.  Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats , 2013, Neuroscience Research.

[49]  V. Lessmann,et al.  Impaired fear extinction learning in adult heterozygous BDNF knock-out mice , 2013, Neurobiology of Learning and Memory.

[50]  T. Bredy,et al.  Activation of BDNF signaling prevents the return of fear in female mice. , 2013, Learning & memory.

[51]  R. Marek,et al.  The amygdala and medial prefrontal cortex: partners in the fear circuit , 2013, The Journal of physiology.

[52]  H. van Praag,et al.  Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice , 2012, Developmental neurobiology.

[53]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[54]  R. Stewart,et al.  Role of BDNF val66met polymorphism on the association between physical activity and incident dementia , 2011, Neurobiology of Aging.

[55]  K. Thomas,et al.  The exclusive induction of extinction is gated by BDNF. , 2010, Learning & memory.

[56]  J. Peters,et al.  Induction of Fear Extinction with Hippocampal-Infralimbic BDNF , 2010, Science.

[57]  W. Falls,et al.  Voluntary exercise improves both learning and consolidation of cued conditioned fear in C57 mice , 2010, Behavioural Brain Research.

[58]  G. Glover,et al.  A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human , 2010, Science.

[59]  Dennis C. Choi,et al.  Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear , 2010, Proceedings of the National Academy of Sciences.

[60]  M. Fleshner,et al.  A behavioral analysis of the impact of voluntary physical activity on hippocampus‐dependent contextual conditioning , 2009, Hippocampus.

[61]  M. Oitzl,et al.  Corticosterone facilitates extinction of fear memory in BALB/c mice but strengthens cue related fear in C57BL/6 mice , 2009, Experimental Neurology.

[62]  Joseph A. Gogos,et al.  Genetic Modulation of BDNF Signaling Affects the Outcome of Axonal Competition In Vivo , 2007, Current Biology.

[63]  Miranda Olff,et al.  Gender differences in posttraumatic stress disorder. , 2007, Psychological bulletin.

[64]  C. Siao,et al.  Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior , 2006, Science.

[65]  R. Dishman,et al.  Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor. , 2004, Behavioral neuroscience.

[66]  P. Burghardt,et al.  The effects of chronic treadmill and wheel running on behavior in rats , 2004, Brain Research.

[67]  R. Swain,et al.  Effects of exercise on Pavlovian fear conditioning. , 2004, Behavioral neuroscience.

[68]  Paresh D Patel,et al.  Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons , 2004, The Journal of Neuroscience.

[69]  M. Egan,et al.  The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function , 2003, Cell.

[70]  M. Otto,et al.  A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. , 2015, Journal of psychiatric research.