Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes

A recent dispersal of modern humans out of Africa is now widely accepted, but the routes taken across Eurasia are still disputed. We show that mitochondrial DNA variation in isolated “relict” populations in southeast Asia supports the view that there was only a single dispersal from Africa, most likely via a southern coastal route, through India and onward into southeast Asia and Australasia. There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the main dispersal from India to Australia ∼65,000 years ago was rapid, most likely taking only a few thousand years.

[1]  R. Foley,et al.  Multiple dispersals and modern human origins , 2005 .

[2]  F. Balloux,et al.  Geography predicts neutral genetic diversity of human populations , 2005, Current Biology.

[3]  Hans-Jürgen Bandelt,et al.  Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia. , 2004, American journal of human genetics.

[4]  Hidetoshi Shimodaira,et al.  Mitochondrial genome variation in eastern Asia and the peopling of Japan. , 2004, Genome research.

[5]  D. Piperno.  Under the Canopy: The Archaeology of Tropical Rain Forests.Edited byJulio Mercader.New Brunswick (New Jersey): Rutgers University Press. $60.00. x + 322 p; ill.; index. ISBN: 0–8135–3142–X. 2003. , 2004 .

[6]  S. Mastana,et al.  Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans , 2004, BMC Genetics.

[7]  James Steele,et al.  Spatial dynamics of human dispersals: Constraints on modelling and archaeological validation , 2004 .

[8]  P. Forster.  Ice Ages and the mitochondrial DNA chronology of human dispersals: a review. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[9]  Hans-Jürgen Bandelt,et al.  Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences. , 2003, American journal of human genetics.

[10]  U. Gyllensten,et al.  Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. , 2003, Genome research.

[11]  T. Kivisild,et al.  Reply to Cordaux and Stoneking , 2003 .

[12]  M. Stoneking,et al.  South Asia, the Andamanese, and the genetic evidence for an "early" human dispersal out of Africa. , 2003, American journal of human genetics.

[13]  P. Underhill,et al.  The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations. , 2003, American journal of human genetics.

[14]  Marty C. Brandon,et al.  Natural selection shaped regional mtDNA variation in humans , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Kivisild,et al.  Phylogeographic differentiation of mitochondrial DNA in Han Chinese. , 2002, American journal of human genetics.

[16]  P. Forster,et al.  Phylogenetic star contraction applied to Asian and Papuan mtDNA evolution. , 2001, Molecular biology and evolution.

[17]  N. Maca-Meyer,et al.  Major genomic mitochondrial lineages delineate early human expansions , 2001, BMC Genetics.

[18]  G. Miller,et al.  Early Human Occupation at Devil's Lair, Southwestern Australia 50,000 Years Ago , 2001, Quaternary Research.

[19]  A. Di Rienzo,et al.  Tracing European founder lineages in the Near Eastern mtDNA pool. , 2000, American journal of human genetics.

[20]  A. Brooks,et al.  The revolution that wasn't: a new interpretation of the origin of modern human behavior. , 2000, Journal of human evolution.

[21]  R. Edwards,et al.  Early human occupation of the Red Sea coast of Eritrea during the last interglacial , 2000, Nature.

[22]  H. Bandelt,et al.  Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa , 1999, Nature Genetics.

[23]  Robert A. Foley,et al.  Principles of Human Evolution , 1997 .

[24]  H. Bandelt,et al.  Mitochondrial footprints of human expansions in Africa. , 1997, American journal of human genetics.

[25]  D. F. Roberts,et al.  The History and Geography of Human Genes , 1996 .

[26]  M. Nei,et al.  Evolutionary relationships of human populations on a global scale. , 1993, Molecular biology and evolution.

[27]  K. Hawkes,et al.  African populations and the evolution of human mitochondrial DNA. , 1991, Science.

[28]  C. Stringer,et al.  Genetic and fossil evidence for the origin of modern humans. , 1988, Science.

[29]  C. Lalueza-Fox,et al.  The genetic origins of the Andaman Islanders. , 2003, American journal of human genetics.

[30]  Clive Gamble,et al.  Radiocarbon evidence for the Lateglacial Human Recolonisation of Northern Europe , 1997, Proceedings of the Prehistoric Society.

[31]  T. H. Andel,et al.  Palaeolithic landscapes of Europe and environs, 150,000-25,000 years ago: An overview , 1996 .

[32]  P. Bellwood,et al.  Prehistory of the Indo-Malaysian Archipelago , 1985 .