Response to Letter Regarding Article, “Role of Diuretics in the Prevention of Heart Failure: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)”

We thank Drs Ben-Dov and Bursztyn for their thoughtful letter regarding our article1 and the role of clinic versus ambulatory blood pressure in assessing the relative impact of antihypertensive treatments on clinical outcomes, especially heart failure. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was designed to allow for recruitment and retention of a large number of patients, with minimal burden to the providers and study participants and a cost structure that …