New Multicomponent Bioerodible Electrospun Nanofibers for Dual-controlled Drug Release

The objective of this study was to evaluate the bioerodible polymer poly(maleic anhydride-alt-2-methoxyethyl vinyl ether) n-butyl hemiester, for multicomponent drug-loaded nanofibers produced by electrospinning. Diclofenac sodium (DS) and human serum albumin (HSA) were used as conventional drug and biopharmaceutical models. The influence of drug loading was correlated to beads presence, morphology and fibers diameter. When DS and HSA were loaded separately, a uniform distribution within fibers and beads was observed. However, when both components were loaded simultaneously, a heterogeneous distribution of DS was observed with a prominent amount in the cylindrical beads. The in vitro drug release evaluation from these nanomaterials displayed an independent delivery of the two components. These studies support the feasibility of multicomponent, bioerodible polymeric nanofibers preparation loaded with combination of traditional drugs and proteins.

[1]  E. Chiellini,et al.  Bioactive polymeric materials for targeted administration of active agents: synthesis and evaluation. , 2008, Macromolecular bioscience.

[2]  E. Chiellini,et al.  A new biocompatible nanoparticle delivery system for the release of fibrinolytic drugs. , 2008, International journal of pharmaceutics.

[3]  H. Yoo,et al.  Electrospun Nanofibers Surface-modified with Fluorescent Proteins: , 2007 .

[4]  N. Ashammakhi,et al.  New Multifunctional Anti-Osteolytic Releasing Bioabsorbable Implant , 2007, The Journal of craniofacial surgery.

[5]  N. Manolova,et al.  Preparation of PLLA/PEG Nanofibers by Electrospinning and Potential Applications , 2007 .

[6]  Nureddin Ashammakhi,et al.  Release of diclofenac sodium from polylactide-co-glycolide 80/20 rods , 2006, Journal of materials science. Materials in medicine.

[7]  R L Reis,et al.  Biodegradable nanomats produced by electrospinning: expanding multifunctionality and potential for tissue engineering. , 2006, Journal of nanoscience and nanotechnology.

[8]  E. Chiellini,et al.  Development of diclofenac sodium releasing bio-erodible polymeric nanomats. , 2006, Journal of nanoscience and nanotechnology.

[9]  E. Suokas,et al.  Self-Reinforced Ciprofloxacin-Releasing Polylactide-Co-Glycolide 80/20 Inhibits Attachment and Biofilm Formation by Staphylococcus Epidermidis: An In Vitro Study , 2006, The Journal of craniofacial surgery.

[10]  J. Seppälä,et al.  Electrospun multifunctional diclofenac sodium releasing nanoscaffold. , 2006, Journal of nanoscience and nanotechnology.

[11]  F. Chiellini,et al.  Bioerodible polymeric nanoparticles for targeted delivery of proteic drugs. , 2006, Journal of nanoscience and nanotechnology.

[12]  A. Mikos,et al.  Electrospinning of polymeric nanofibers for tissue engineering applications: a review. , 2006, Tissue engineering.

[13]  David L Kaplan,et al.  Electrospun silk-BMP-2 scaffolds for bone tissue engineering. , 2006, Biomaterials.

[14]  A. Salgado,et al.  Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering , 2005, Journal of materials science. Materials in medicine.

[15]  Yan Li,et al.  A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Anthony S Weiss,et al.  Electrospun protein fibers as matrices for tissue engineering. , 2005, Biomaterials.

[17]  Kam W Leong,et al.  Sustained release of proteins from electrospun biodegradable fibers. , 2005, Biomacromolecules.

[18]  S. Ramakrishna,et al.  Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. , 2005, Biomaterials.

[19]  R. W. Tock,et al.  Electrospinning of nanofibers , 2005 .

[20]  Andreas Greiner,et al.  Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. , 2005, Biomacromolecules.

[21]  Hongliang Jiang,et al.  Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes , 2004, Journal of biomaterials science. Polymer edition.

[22]  Joel Rosenblatt,et al.  Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[23]  E. Chiellini,et al.  Nanoparticle systems for the targeted release of active principles of proteic nature , 2003, Journal of materials science. Materials in medicine.

[24]  J. Vacanti,et al.  A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. , 2003, Biomaterials.

[25]  Linda G Griffith,et al.  Emerging Design Principles in Biomaterials and Scaffolds for Tissue Engineering , 2002, Annals of the New York Academy of Sciences.

[26]  W. Mark Saltzman,et al.  Building drug delivery into tissue engineering design , 2002, Nature Reviews Drug Discovery.

[27]  E. Chiellini,et al.  Targeted Administration of Proteic Drugs. I. Preparation of Polymeric Nanoparticles , 2001 .

[28]  James K. Hirvonen,et al.  Controlled deposition of electrospun poly(ethylene oxide) fibers , 2001 .

[29]  Y. Ikada,et al.  Biodegradable polyesters for medical and ecological applications , 2000 .

[30]  E. Chiellini,et al.  Multifunctional bioerodible/biodegradable polymeric materials , 1995 .

[31]  Emo Chiellinia,et al.  New polymeric hydrogel formulations for the controlled release of α-interferon , 1992 .

[32]  E. Chiellini,et al.  Partial Esters of Alternating Copolymers of Maleic Anhydride and Alkyl Vinyl Ethers for Pharmaceutical Applications , 1992 .

[33]  E. Chiellini,et al.  Polymer Drug Delivery Systems in Ophthalmic Applications , 1988 .

[34]  M. Vert,et al.  Optically Active Polyelectrolytes with Variable Hydrophobicity. 2. Effects of pH-Induced Chromophore and Conformation Changes on Chiroptical Properties of Acrylic Acid/(+)-N-(sec-Butyl)-N-methylacrylamide Copolymers , 1978 .

[35]  E. Chiellini,et al.  Biodegradable nanomats produced by electrospinning: expanding multifunctionality and potential for tissue engineering. , 2006, Journal of nanoscience and nanotechnology.

[36]  M. Kotaki,et al.  Recent advances in polymer nanofibers. , 2004, Journal of nanoscience and nanotechnology.

[37]  J. Deitzel,et al.  The effect of processing variables on the morphology of electrospun nanofibers and textiles , 2001 .

[38]  E. Chiellini,et al.  Inserts for sustained ocular delivery of pilocarpine: evaluation of a series of partial esters of (maleic acid-alkyl vinyl ether) alternating copolymers , 1988 .

[39]  E. Chiellini,et al.  Optically Active Polyelectrolytes with Variable Hydrophobicity. 3. Effects of pH-Induced Chromophore and Conformation Changes on Chiroptical Properties of Alternating Copolymers of Maleic Acid and Optically Active 1-Methylalkyl Vinyl Ethers , 1979 .

[40]  E. Chiellini,et al.  Optically active alternating copolymers of maleic anhydride and alkylvinylethers , 1978 .