Alendronate Reduces the Risk of Multiple Symptomatic Fractures: Results from the Fracture Intervention Trial

To evaluate the effect of alendronate on the occurrence rate of multiple symptomatic fractures and on the risk of multiple symptomatic fractures (likelihood of having more than one fracture diagnosed because of the symptoms the fractures caused over the study period) among women with osteoporosis.

[1]  S. Cummings,et al.  Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. , 2000, The Journal of clinical endocrinology and metabolism.

[2]  P. Lips,et al.  Consequences of Vertebral Deformities in Older Men and Women , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  T. Abbott,et al.  Patients with Prior Fractures Have an Increased Risk of Future Fractures: A Summary of the Literature and Statistical Synthesis , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  J. Cauley,et al.  Prevalent Vertebral Deformities Predict Mortality and Hospitalization in Older Women with Low Bone Mass , 2000, Journal of the American Geriatrics Society.

[5]  S. Cummings,et al.  Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research Group. , 2000, Archives of internal medicine.

[6]  H K Genant,et al.  Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. , 1999, JAMA.

[7]  C C Glüer,et al.  Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. , 1999, JAMA.

[8]  J Pearson,et al.  Prevalent Vertebral Deformities Predict Hip Fractures and New Vertebral Deformities but Not Wrist Fractures , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  A. LaCroix,et al.  Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. , 1998, JAMA.

[10]  S. Cummings,et al.  The Association of Radiographically Detected Vertebral Fractures with Back Pain and Function: A Prospective Study , 1998, Annals of Internal Medicine.

[11]  K. E. Dretakis,et al.  Possible Predisposing Factors for the Second Hip Fracture , 1998, Calcified Tissue International.

[12]  C. Cooper,et al.  The crippling consequences of fractures and their impact on quality of life. , 1997, The American journal of medicine.

[13]  S. Cummings,et al.  Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures , 1996, The Lancet.

[14]  P. Ross,et al.  Vertebral fracture and other predictors of physical impairment and health care utilization. , 1996, Archives of internal medicine.

[15]  Michael C. Nevitt,et al.  Mortality Following Fractures in Older Women: The Study of Osteoporotic Fractures , 1996 .

[16]  P. Ross,et al.  Vertebral fractures and other predictors of back pain among older women , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  D. Gold.  The clinical impact of vertebral fractures: quality of life in women with osteoporosis. , 1996, Bone.

[18]  J Dequeker,et al.  Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. , 1995, The New England journal of medicine.

[19]  M. Nevitt,et al.  Vertebral fracture assessment using a semiquantitative technique , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  D. Gold,et al.  Association of osteoporotic vertebral compression fractures with impaired functional status. , 1993, The American journal of medicine.

[21]  C. Cooper,et al.  Population-based study of survival after osteoporotic fractures. , 1993, American journal of epidemiology.

[22]  H K Genant,et al.  Contribution of vertebral deformities to chronic back pain and disability , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  S. Cummings,et al.  Which Fractures Are Associated with Low Appendicular Bone Mass in Elderly Women , 1991 .

[24]  R. Epstein,et al.  Pre-existing fractures and bone mass predict vertebral fracture incidence in women. , 1991, Annals of internal medicine.

[25]  R. Ziegler,et al.  A study of complaints and their relation to vertebral destruction in patients with osteoporosis. , 1990, Bone and mineral.

[26]  R. Gill,et al.  Cox's regression model for counting processes: a large sample study : (preprint) , 1982 .

[27]  Margo J. Anderson,et al.  The Census , 1921, The Hospital.

[28]  M. Hooper,et al.  Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis , 2000, Osteoporosis International.

[29]  L. J. Wei,et al.  Regression analysis of multivariate incomplete failure time data by modeling marginal distributions , 1989 .

[30]  P. Benum,et al.  The second hip fracture. An epidemiologic study. , 1986, Acta orthopaedica Scandinavica.