Evidence of a collateralized climbing fiber projection from the inferior olive to the flocculus and vestibular nuclei in rabbits

In albino rabbits, horseradish peroxidase injections confined to vestibular nuclei retrogradely labeled neurons in the dorsal cap of the contralateral inferior olive. Mapping with stimulating electrodes revealed that stimulation of the lateral aspect of the medial vestibular nucleus and the medial aspect of the inferior vestibular nucleus evoked field potentials representing antidromic activation of contralateral dorsal cap neurons. These responses interfered with the antidromic response evoked from the contralateral flocculus and orthodromic responses evoked from the contralateral retina, suggesting that dorsal cap neurons which both receive retinal input and project to the flocculus send collaterals to vestibular nuclei.

[1]  Masao Ito,et al.  Functional localization in the rabbit's cerebellar flocculus determined in relationship with eye movements , 1977, Neuroscience Letters.

[2]  T. Hashikawa,et al.  Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labeled amino acids as tracers , 1979, Neuroscience.

[3]  N. Barmack,et al.  A subparafascicular projection to the medial vestibular nucleus of the rabbit , 1979, Brain Research.

[4]  A. Brodal,et al.  The projection of the "vestibulocerebellum" onto the vestibular nuclei in the cat. , 1967, Archives italiennes de biologie.

[5]  Miyuki Yamamoto,et al.  Localization of rabbit's flocculus purkinje cells projecting to the cerebellar lateral nucleus and the nucleus prepositus hypoglossi investigated by means of the horseradish peroxidase retrograde axonal transport , 1978, Neuroscience Letters.

[6]  J. Simpson,et al.  Climbing fiber responses evoked in vestibulocerebellum of rabbit from visual system. , 1973, Journal of neurophysiology.

[7]  P. Jastreboff,et al.  A neuronal correlate in rabbit's cerebellum to adaptive modification of the vestibulo-ocular reflex , 1978, Brain Research.

[8]  A. Graybiel,et al.  A microelectrophoretic delivery technique for use with horseradish peroxidase. , 1974, Brain research.

[9]  J. Voogd,et al.  The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of cat cerebellum , 1977, The Journal of comparative neurology.

[10]  J. Courville,et al.  Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase , 1977, Brain Research.

[11]  Masao Ito,et al.  Functional localization in the rabbits inferior olive determined in connection with the vestibulo-ocular reflex , 1978, Neuroscience Letters.

[12]  Alf Brodal,et al.  Experimentelle Untersuchungen über die olivocerebellare Lokalisation , 1940 .

[13]  L. Heimer,et al.  The afferent connections of the main and the accessory olfactory bulb formations in the rat: An experimental HRP‐study , 1978, The Journal of comparative neurology.

[14]  Y. Olsson,et al.  A sensitive method for histochemical demonstration of horseradish peroxidase in neurons following retrograde axonal transport , 1978, Brain Research.

[15]  A. Brodal,et al.  The olivocerebellar projection studied with the method of retrograde axonal transport of horseradish peroxidase. V. The projections to the flocculonodular lobe and the paraflocculus in the rabbit , 1977, The Journal of comparative neurology.

[16]  J. Simpson,et al.  Afferents to the vestibulo-cerebellum and the origin of the visual climbing fibers in the rabbit , 1975, Brain Research.

[17]  M. Yamamoto,et al.  Specific patterns of neuronal connexions involved in the control of the rabbit's vestibulo‐ocular reflexes by the cerebellar flocculus. , 1977, The Journal of physiology.

[18]  M. Mesulam,et al.  Sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods. , 1979, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[19]  S. Highstein,et al.  Vestibular nucleus neurons relaying excitation from the anterior canal to the oculomotor nucleus , 1978, Brain Research.

[20]  Ichiro Shimoyama,et al.  Differential localization of rabbit's flocculus Purkinje cells projecting to the medial and superior vestibular nuclei, investigated by means of the horseradish peroxidase retrograde axonal transport , 1977, Neuroscience Letters.