论文信息 - The effects of caffeine on the expression of potentially lethal and sublethal damage in gamma-irradiated cultured mammalian cells.

The effects of caffeine on the expression of potentially lethal and sublethal damage in gamma-irradiated cultured mammalian cells.

Caffeine was found to potentiate single-dose cobalt-60 γ-ray-induced lethality in human T-1 and Chinese hamster V79-79 cells when present at 2.0 to 2.5 mM for 21 to 48 hr after irradiation. In split-dose experiments, 2 mM caffeine apparently did not affect survival when present only for the 4 hr between doses. As 4 hr is sufficient time for these cells to complete sublethal damage repair it is concluded that caffeine affects the expression of potentially lethal damage but not the expression of sublethal damage.

P. Todd | C. B. Schroy

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