Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.

[1]  J. Broderick,et al.  Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes , 2007, BMC Medical Genetics.

[2]  Mathias Jucker,et al.  Mechanism of Cerebral β‐Amyloid Angiopathy: Murine and Cellular Models , 2006 .

[3]  J. Broderick,et al.  Association of Apolipoprotein E4 and Haplotypes of the Apolipoprotein E Gene With Lobar Intracerebral Hemorrhage , 2005, Stroke.

[4]  Irene Otte-Höller,et al.  Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. , 2005, The American journal of pathology.

[5]  R. Wilson,et al.  The Apolipoprotein E &egr;4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons , 2005 .

[6]  D. Holtzman,et al.  Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model , 2005, The Journal of Neuroscience.

[7]  S. D. Moore,et al.  Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology , 2005, Neurobiology of Disease.

[8]  W. H. Jordan,et al.  Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β , 2005, The Journal of Neuroscience.

[9]  Sung Hwan Yun,et al.  ApoE isoform affects LTP in human targeted replacement mice , 2004, Neuroreport.

[10]  J. Nicoll,et al.  Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage , 2004, The Lancet Neurology.

[11]  Bruce J Aronow,et al.  ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo , 2004, Neuron.

[12]  O. Wiestler,et al.  Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline , 2003, Journal of neuropathology and experimental neurology.

[13]  D. Holtzman,et al.  Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice , 2003, The Journal of Neuroscience.

[14]  S. Love,et al.  APOEɛ4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein , 2003 .

[15]  S. Greenberg Cerebral Amyloid Angiopathy and Vessel Dysfunction , 2002, Cerebrovascular Diseases.

[16]  M. Gurney,et al.  Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain , 2001, Annals of neurology.

[17]  M. Staufenbiel,et al.  Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy , 2001, The Journal of Neuroscience.

[18]  Ian G. McKeith,et al.  Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales , 2001, The Lancet.

[19]  Bradley T. Hyman,et al.  Senile dementia associated with amyloid β protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele , 2000, Acta Neuropathologica.

[20]  I. Tesseur,et al.  Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons , 2000, Neurobiology of Aging.

[21]  D. Graham,et al.  CLINICAL NEUROSCIENCE: Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage , 2000 .

[22]  K. Furie,et al.  Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. , 2000, The New England journal of medicine.

[23]  S. Paul,et al.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[24]  L. Walker,et al.  Cerebrovascular amyloidosis: experimental analysis in vitro and in vivo. , 1999, Histology and histopathology.

[25]  Masahiko Watanabe,et al.  Apo E structure determines VLDL clearance and atherosclerosis risk in mice. , 1999, The Journal of clinical investigation.

[26]  Wei Zhang,et al.  Apolipoprotein E Alters Metabolism of AβPP in Cells Engaged in β-Amyloidosis , 1999 .

[27]  Yu-Min Kuo,et al.  Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. , 1998, The American journal of pathology.

[28]  J. Nicoll,et al.  High frequency of apolipoprotein E ϵ2 allele is specific for patients with cerebral amyloid angiopathy-related haemorrhage , 1998, Neuroscience Letters.

[29]  S. Paul,et al.  Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.

[30]  N. Maeda,et al.  Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.

[31]  A. Hofman,et al.  Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. , 1997, JAMA.

[32]  M. Yamada,et al.  Cerebral amyloid angiopathy in the elderly: the clinicopathological features, pathogenesis, and risk factors. , 1997, Journal of medical and dental sciences.

[33]  W. Strittmatter,et al.  ApoE genotype and survival from intracerebral haemorrhage , 1995, The Lancet.

[34]  B. Hyman,et al.  Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy , 1995 .

[35]  L. Mucke,et al.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.

[36]  C. Graffagnino,et al.  A molecular genetic study of intracerebral hemorrhage. , 1994, Archives of neurology.

[37]  G. Getz,et al.  Isoform-specific binding of apolipoprotein E to beta-amyloid. , 1994, The Journal of biological chemistry.

[38]  D. Ingram,et al.  Age-related deposition of glia-associated fibrillar material in brains of c57BL/6 mice , 1994, Neuroscience.

[39]  A D Roses,et al.  Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Thomas Wisniewski,et al.  Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.

[42]  Wang Ys,et al.  Pathological study on cerebral amyloid angiopathy. , 1991, Chinese medical journal.

[43]  E. Boerwinkle,et al.  The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. , 1991, American journal of human genetics.

[44]  B. Trapp,et al.  Deposits of amyloid beta protein in the central nervous system of transgenic mice. , 1991, Science.

[45]  P. Krack,et al.  Age-related spontaneous intracerebral hematoma in a German community. , 1990, Stroke.

[46]  D. T. Vernier,et al.  Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. , 1990, Journal of lipid research.

[47]  S. Wakai,et al.  Histological verification of microaneurysms as a cause of cerebral haemorrhage in surgical specimens. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[48]  C. Bergeron,et al.  Amyloid Angiopathy in Alzheimer's Disease , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[49]  E. Otomo,et al.  Cerebral amyloid angiopathy in the aged , 1987, Journal of Neurology.

[50]  H. Vinters,et al.  Amyloidosis of cerebral arteries. , 2003, Advances in neurology.

[51]  M. Jucker,et al.  Transgenic mouse models of cerebral amyloid angiopathy. , 2001, Advances in experimental medicine and biology.

[52]  D. Selkoe,et al.  Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. , 1992, The American journal of pathology.