Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
暂无分享,去创建一个
Karl Mechtler | Carol Ann Homon | Stephen Rea | Stefan Kubicek | C. Homon | T. Jenuwein | K. Mechtler | S. Rea | E. Hickey | S. Kubicek | Qiang Zhang | R. O'Sullivan | M. Teodoro | T. A. Kelly | Thomas Jenuwein | J. Kowalski | Qiang Zhang | E. M. August | Terence A Kelly | Eugene R Hickey | Roderick J O'Sullivan | E Michael August | Miguel L Teodoro | Jennifer A Kowalski | R. O’Sullivan | Roderick J. O’Sullivan | E. August
[1] T. Jenuwein. The epigenetic magic of histone lysine methylation , 2006, The FEBS journal.
[2] M. Grever,et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. , 2006, Cancer research.
[3] Danny Reinberg,et al. Histone Lysine Demethylases and Their Impact on Epigenetics , 2006, Cell.
[4] Kelly M. McGarvey,et al. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. , 2006, Cancer research.
[5] S. Baylin,et al. Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? , 2006, Nature Reviews Cancer.
[6] H. Cedar,et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis , 2006, Nature Cell Biology.
[7] Axel Imhof,et al. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 , 2005, Nature chemical biology.
[8] Tsutomu Ohta,et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. , 2005, Genes & development.
[9] Martin Radolf,et al. The profile of repeat‐associated histone lysine methylation states in the mouse epigenome , 2005, The EMBO journal.
[10] J. Issa,et al. Histone Deacetylase Inhibitors: A Review of Their Clinical Status as Antineoplastic Agents , 2005, Cancer investigation.
[11] Gangning Liang,et al. Preferential response of cancer cells to zebularine. , 2004, Cancer cell.
[12] A. Roopra,et al. Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. , 2004, Molecular cell.
[13] Randall W King,et al. Small Molecule Regulators of Protein Arginine Methyltransferases* , 2004, Journal of Biological Chemistry.
[14] Shi Huang,et al. Inactivation of a histone methyltransferase by mutations in human cancers. , 2003, Cancer research.
[15] Yi Zhang,et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. , 2003, Molecular cell.
[16] E. Selker,et al. Structural basis for the product specificity of histone lysine methyltransferases. , 2003, Molecular cell.
[17] E. Heard,et al. Role of Histone Methyltransferase G9a in CpG Methylation of the Prader-Willi Syndrome Imprinting Center* , 2003, The Journal of Biological Chemistry.
[18] Andrew J. Bannister,et al. Unsafe SETs: histone lysine methyltransferases and cancer. , 2002, Trends in biochemical sciences.
[19] H. Kato,et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. , 2002, Genes & development.
[20] Shi Huang. Histone methyltransferases, diet nutrients and tumour suppressors , 2002, Nature Reviews Cancer.
[21] David M. Livingston,et al. A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells , 2002, Science.
[22] D. Reinberg,et al. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. , 2002, Genes & development.
[23] Hengbin Wang,et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. , 2001, Molecular cell.
[24] Brian D. Strahl,et al. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1 , 2001, Current Biology.
[25] C. Ponting,et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases , 2000, Nature.
[26] G. Weidinger. Pharmacokinetic and pharmacodynamic properties and therapeutic use of bunazosin in hypertension. A review. , 1995, Arzneimittel-Forschung.
[27] Peter A. Jones,et al. Epigenetic therapy of cancer: past, present and future , 2006, Nature Reviews Drug Discovery.
[28] G. Schotta,et al. Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome. , 2004, Cold Spring Harbor symposia on quantitative biology.
[29] R. Jaenisch,et al. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. , 2003, The New England journal of medicine.
[30] W. Nawrocka. Syntheses and pharmacological properties of new 2-aminobenzimidazole derivatives. , 1996, Bollettino chimico farmaceutico.