Integrated school-based surveillance for soil-transmitted helminth infections and lymphatic filariasis in Gampaha district, Sri Lanka.

We explored the practicality of integrating surveillance for soil-transmitted helminthiasis (STH, assessed by Kato-Katz) with transmission assessment surveys for lymphatic filariasis (LF) in two evaluation units (EUs) in Gampaha district, Sri Lanka (population 2.3 million). The surveys were performed 6 years after five annual rounds of mass drug administration with diethylcarbamazine and albendazole. Each transmission assessment survey tested children (N = 1,462 inland EU; 1,642 coastal EU) sampled from 30 primary schools. Low filarial antigenemia rates (0% and 0.1% for the inland and coastal EUs) suggest that LF transmission is very low in this district. The STH rates and stool sample participation rates were 0.8% and 61% (inland) and 2.8% and 58% (coastal). Most STH detected were low or moderate intensity Trichuris trichiura infections. The added cost of including STH testing was ∼$5,000 per EU. These results suggest that it is feasible to integrate school-based surveillance for STH and LF.

[1]  P. J. Hooper,et al.  The effects of integration on financing and coverage of neglected tropical disease programs. , 2013, The American journal of tropical medicine and hygiene.

[2]  L. Rinaldi,et al.  Mini-FLOTAC, an Innovative Direct Diagnostic Technique for Intestinal Parasitic Infections: Experience from the Field , 2013, PLoS neglected tropical diseases.

[3]  T. C. Yahathugoda,et al.  An independent evaluation of the national programme for the elimination of lymphatic filariasis , 2013 .

[4]  Global programme to eliminate lymphatic filariasis: progress report for 2012. , 2013, Releve epidemiologique hebdomadaire.

[5]  M. Stanton,et al.  Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis - a rapid assessment methodology to assess impact , 2012, Parasites & Vectors.

[6]  Rosanna W. Peeling,et al.  Neglected Tropical Diseases : Rationale and Target Product Profiles , 2018 .

[7]  P. Mbabazi,et al.  Preventive Chemotherapy and Transmission Control (PCT) databank: a tool for planning, implementation and monitoring of integrated preventive chemotherapy for control of neglected tropical diseases. , 2012, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[8]  N. D. Silva,et al.  Can we eliminate soil-transmitted helminth infections in Sri Lanka? , 2012, The Ceylon medical journal.

[9]  A. Garba,et al.  Schistosomiais and Soil-Transmitted Helminth Control in Niger: Cost Effectiveness of School Based and Community Distributed Mass Drug Administration , 2011, PLoS neglected tropical diseases.

[10]  Margaret C Baker,et al.  Integrated Implementation of Programs Targeting Neglected Tropical Diseases through Preventive Chemotherapy: Proving the Feasibility at National Scale , 2011, The American journal of tropical medicine and hygiene.

[11]  A. Pathmeswaran,et al.  Effect of repeated mass chemotherapy for filariasis control on soil-transmitted helminth infections in Sri Lanka. , 2008, Ceylon Medical Journal.

[12]  J. Utzinger,et al.  Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. , 2008, JAMA.

[13]  S. Weerasekara,et al.  Social mobilisation, drug coverage and compliance and adverse reactions in a Mass Drug Administration (MDA) Programme for the Elimination of Lymphatic Filariasis in Sri Lanka , 2007, Filaria journal.

[14]  Jürg Utzinger,et al.  A blueprint for success: integration of neglected tropical disease control programmes. , 2006, Trends in parasitology.

[15]  P. J. Hooper,et al.  Projected benefits from integrating NTD programs in sub-Saharan Africa. , 2006, Trends in parasitology.

[16]  A. Pathmeswaran,et al.  Health status of primary schoolchildren in Sri Lanka , 2010 .

[17]  N. Karunaweera,et al.  Effects of climatic, socio–economic and behavioural factors on the transmission of hookworm (Necator americanus) on two low-country plantations in Sri Lanka , 2005, Annals of tropical medicine and parasitology.

[18]  N. Karunaweera,et al.  Socio–economic and behavioural factors affecting the prevalence of Ascaris infection in a low-country tea plantation in Sri Lanka , 2004, Annals of tropical medicine and parasitology.

[19]  J. Horton Albendazole: a broad spectrum anthelminthic for treatment of individuals and populations , 2002, Current opinion in infectious diseases.

[20]  T. Gyorkos,et al.  Helminth Control in School-age Children: A Guide for Managers of Control Programmes , 2002 .

[21]  Prevention and control of schistosomiasis and soil-transmitted helminthiasis , 2004 .

[22]  G. Pasvol Training Manual on Diagnosis of Intestinal Parasites: edited by Lawrence Ash, Thomas Orihel, Lorenzo Savioli, Muna Abu Sin, Antonio Montresor, Elil Renganathan , 1999 .

[23]  E. Ottesen,et al.  Training Manual on Diagnosis of Intestinal Parasites , 1999 .

[24]  The use of essential drugs. Eighth report of the WHO Expert Committee (including the revised Model List of Essential Drugs). , 1998, World Health Organization technical report series.

[25]  A. Dissanaike Filariasis in Ceylon then (1961) and in Sri Lanka now (1990-30 years on). , 1991, Annals of tropical medicine and parasitology.

[26]  U. Schweinfurth Filarial diseases in Ceylon: a geographic and historical analysis. , 1983, Ecology of disease.