A ROLE OF NATURAL POLYMERS USED IN FORMULATION OF PHARMACEUTICAL DOSAGE FORMS: A REVIEW

All pharmaceutical dosage forms contain many additives besides the active ingredients to assist manufacturing and to obtain the desired effect to the pharmaceutical active ingredients. The advances in drug delivery have simultaneously urged the discovery of novel excipients which are safe and fulfil specific functions and directly or indirectly influence the rate and extent of release and or absorption. Earlier used natural excipients are carrageenan, thaumatin, lard, shilajit, aerosil, myrobalan, and storax. Use of these natural excipients to deliver the bioactive agents has been hampered by the synthetic materials. Excipients are any component other than the active substances intentionally added to formulation of a dosage form. Novel drug delivery systems are developed to address the challenges of drug development such as bioavailability, permeability, and poor solubility. This review discusses about the majority of these plant-derived polymeric compounds, their sources extraction procedure, chemical constituents, uses and so delivery system recent investigations as excipients in novel drug.

[1]  Pharmaceutical Press,et al.  Handbook of Pharmaceutical Excipients , 2012 .

[2]  N. Tavakoli,et al.  Evaluation of Okra gum as a binder in tablet dosage forms , 2010 .

[3]  R. Deveswaran,et al.  Design and Characterization of Diclofenac sodium tablets containing Tamarind seed polysaccharide as Release retardant , 2009 .

[4]  P. Balakrishna,et al.  Design and Evaluation of Controlled Release Bhara Gum Microcapsules of Famotidine for Oral Use , 2008 .

[5]  Baljit Singh,et al.  In vitro release dynamics of model drugs from psyllium and acrylic acid based hydrogels for the use in colon specific drug delivery , 2008, Journal of materials science. Materials in medicine.

[6]  B. Mukherjee,et al.  Gum Cordia: A Novel Matrix Forming Material for Enteric resistant and Sustained Drug Delivery—A Technical Note , 2008, AAPS PharmSciTech.

[7]  G. Savant,et al.  Evaluation of Sterculia foetida Gum as Controlled Release Excipient , 2008, AAPS PharmSciTech.

[8]  Y. Krishnaiah,et al.  In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride , 2005, AAPS PharmSciTech.

[9]  T. Whitmore.  Utilization, potential, and conservation ofAgathis, a genus of tropical Asian conifers , 2008, Economic Botany.

[10]  S. Parkar,et al.  MICROENCAPSULATION OF PROBIOTICS USING KIWIFRUIT POLYSACCHARIDE AND ALGINATE CHITOSAN , 2007 .

[11]  Ji Zhang,et al.  Preparation and Characterization of Composite Magnetic Microspheres , 2007 .

[12]  Michael A. Odeniyi,et al.  Matrix properties of a new plant gum in controlled drug delivery , 2007, Archives of pharmacal research.

[13]  A. Attama,et al.  Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation , 2007, Acta pharmaceutica.

[14]  M. Emeje,et al.  EVALUATION OF OKRA GUM AS A DRY BINDER IN PARACETAM OL TABLET FORMULATIONS , 2007 .

[15]  D. Gowda,et al.  Xanthan and locust bean gum (from Ceratonia siliqua) matrix tablets for oral controlled delivery of propranolol hydrochloride , 2007 .

[16]  Sanjay K. Jain,et al.  Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. , 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[17]  John G. Lyons,et al.  The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[18]  P. Satturwar,et al.  Gum copal and gum damar : Novel matrix forming materials for sustained drug delivery , 2006 .

[19]  Oluwatoyin A. Odeku,et al.  Assessment of Albizia zygia gum as a binding agent in tablet formulations. , 2005, Acta pharmaceutica.

[20]  D. L. Munday,et al.  Evaluation of Selected Polysaccharide Excipients in Buccoadhesive Tablets for Sustained Release of Nicotine , 2004, Drug development and industrial pharmacy.

[21]  M. Tobyn,et al.  Influence of Physiological Variables on the In Vitro Drug-Release Behavior of a Polysaccharide Matrix Controlled-Release System , 2003, Drug development and industrial pharmacy.

[22]  O. Itiola,et al.  Evaluation of the Effects of Khaya Gum on the Mechanical and Release Properties of Paracetamol Tablets , 2003, Drug development and industrial pharmacy.

[23]  T. G. Kulkarni,et al.  Evaluation of Binding Properties of Selected Natural Mucilages , 2002 .

[24]  R. Srinivasan,et al.  Study on Flocculation Efficiency of Okra Gum in Sewage Waste Water , 2001 .

[25]  I. A. Ross.  Medicinal Plants of the World: Chemical Constituents, Traditional, and Modern Medicinal Uses , 2014 .

[26]  A. Mitra,et al.  Evaluation of the gum from Hakea gibbosa as a sustained-release and mucoadhesive component in buccal tablets. , 1999, Pharmaceutical development and technology.

[27]  N. B. Shankaracharya.  Tamarind - chemistry, technology and uses - a critical appraisal. , 1998 .

[28]  S. Mccarthy,et al.  Review of konjac glucomannan , 1997, Journal of environmental polymer degradation.

[29]  A. Dwivedi,et al.  Tamarind Seed Polyose : A Potential Polysaccharide For Sustained Release Of Verapamil Hydrochloride As a Model Drug , 1997 .

[30]  P. J. Antony,et al.  A New Disintegrant for Pharmaceutical Dosage Forms , 1997 .

[31]  F. Goycoolea,et al.  Rheology and Aggregation of Cactus (Opuntia ficus-indica) Mucilage in Solution , 1997 .

[32]  B. Escalante,et al.  Antiinflammatory activity of extracts from Aloe vera gel. , 1996, Journal of ethnopharmacology.

[33]  S. C. Churms,et al.  Molecular structures of gum exudates from Hakea species. , 1993, Phytochemistry.

[34]  F. García-Godoy,et al.  Effect of a resin lining and rebonding on the marginal leakage of amalgam restorations. , 1993, Journal of dentistry.

[35]  V. Dixit,et al.  Studies on gums and their derivatives as binding agents. , 1988 .

[36]  A. Bhattacharjee,et al.  Plant gums of the genus Khaya. Part IV. Major components of Khaya ivorensis gum. Part V. Further studies on Khaya senegalensis gum. , 1970 .