Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease

Eosinophil cationic protein (ECP): A review on molecular and biological properites and the use of ECP as a marker of eosinophil activation in disease

[1]  I. Higashimoto,et al.  Possible release of eosinophil granule proteins in response to signaling from intercellular adhesion molecule-1 and its ligands. , 1995, International archives of allergy and immunology.

[2]  S. Elsayed,et al.  Increased fecal eosinophil cationic protein in inflammatory bowel disease. , 1993, Hepato-gastroenterology.

[3]  H. Boushey,et al.  Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation. , 1994, The Journal of allergy and clinical immunology.

[4]  P. Venge,et al.  Neutrophils and eosinophils , 1996 .

[5]  R. Townley,et al.  Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation. , 1993, International archives of allergy and immunology.

[6]  J. Hed,et al.  Counts of activated blood eosinophils for monitoring asthma , 1993, Allergy.

[7]  J. Bousquet,et al.  Corticosteroid reversibility in COPD is related to features of asthma. , 1997, American journal of respiratory and critical care medicine.

[8]  P. O'Byrne,et al.  Induced sputum, bronchoalveolar lavage and blood from mild asthmatics: inflammatory cells, lymphocyte subsets and soluble markers compared. , 1998, European Respiratory Journal.

[9]  P. Venge,et al.  Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement. , 1984, Annals of the rheumatic diseases.

[10]  J. Lundahl,et al.  The degree of natural allergen exposure modifies eosinophil activity markers in the circulation of patients with mild asthma , 1996, Allergy.

[11]  A. Konno,et al.  Mode of action of a topical steroid on immediate phase reaction after antigen challenge and nonspecific nasal hyperreactivity in nasal allergy. , 1994, International archives of allergy and immunology.

[12]  F. Hargreave,et al.  Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. , 1996, American journal of respiratory and critical care medicine.

[13]  T. Halstensen,et al.  Monoclonal antibody EG2 does not provide reliable immunohistochemical discrimination between resting and activated eosinophils. , 1994, Journal of immunological methods.

[14]  I. Olsson,et al.  Morphological studies on the killing of schistosomula of Schistosoma mansoni by human eosinophil and neutrophil cationic proteins in vitro , 1981, Parasite immunology.

[15]  M. Capron,et al.  Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia. , 1993, Thorax.

[16]  H. Boushey,et al.  Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. , 1995, American journal of respiratory and critical care medicine.

[17]  R. Garnier,et al.  Clinical and socio‐professional fate of isocyanate‐induced asthma , 1987, Clinical allergy.

[18]  L. Lichtenstein,et al.  Ragweed-specific antibodies in bronchoalveolar lavage fluids and serum before and after segmental lung challenge: IgE and IgA associated with eosinophil degranulation. , 1998, The Journal of allergy and clinical immunology.

[19]  P. Venge,et al.  The influence of IL-3, IL-5, and GM-CSF on normal human eosinophil and neutrophil C3b-induced degranulation. , 1993, Allergy.

[20]  D. Vinatier,et al.  Decreased expression of eosinophil peroxidase and major basic protein messenger RNAs during eosinophil maturation. , 1992, Blood.

[21]  E. Olson,et al.  Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[22]  W. Hocking.  Atlas of Blood Cells: Function and Pathology , 1989 .

[23]  M. Okano,et al.  Eosinophil cationic protein in the nasal secretions of patients with mite allergic rhinitis , 1993, The Laryngoscope.

[24]  D. Tenen,et al.  Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity , 1989, The Journal of experimental medicine.

[25]  J. Fahy,et al.  Comparison of two methods of collecting induced sputum in asthmatic subjects. , 1996, The European respiratory journal.

[26]  B. Wüthrich,et al.  Eosinophil cationic protein in sputum is dependent on temperature and time. , 1998, The European respiratory journal.

[27]  J. Bousquet,et al.  Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. , 1993, The Journal of allergy and clinical immunology.

[28]  H. Bisgaard,et al.  Early and late nasal symptom response to allergen challenge , 1993, Allergy.

[29]  P. Venge,et al.  Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline. , 1990, The American review of respiratory disease.

[30]  H. Bisgaard,et al.  Allergen-induced increase of eosinophil cationic protein in nasal lavage fluid: effect of the glucocorticoid budesonide. , 1990, The Journal of allergy and clinical immunology.

[31]  H. Kita,et al.  Tyrosine phosphorylation and inositol phosphate production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? , 1994, The Journal of allergy and clinical immunology.

[32]  D. Koller,et al.  Clinical value of monitoring eosinophil activity in asthma. , 1995, Archives of disease in childhood.

[33]  H. Sluiter,et al.  Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. , 1985, The American review of respiratory disease.

[34]  L. Boulet,et al.  Identification and analysis of eosinophils by flow cytometry using the depolarized side scatter-saponin method. , 1997, Cytometry.

[35]  I. Iwamoto,et al.  Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils. , 1994, International archives of allergy and immunology.

[36]  I. Olsson,et al.  Cationic proteins of human granulocytes. I. Isolation of the cationic proteins from the granules of leukaemic myeloid cells. , 2009 .

[37]  I. Olsson,et al.  Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells. , 1974, Blood.

[38]  U. Andersson,et al.  A new membrane permeabilization method for the detection of intracellular antigens by flow cytometry. , 1989, Journal of immunological methods.

[39]  D. Zucker-Franklin,et al.  Atlas of Blood Cells: Function and Pathology , 1988 .

[40]  I. Olsson,et al.  Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. , 1977, Laboratory investigation; a journal of technical methods and pathology.

[41]  C. Bindslev‐Jensen,et al.  Measurement of eosinophil cationic protein (ECP) and eosinophil protein X/eosinophil derived neurotoxin (EPX/EDN). Time and temperature dependent spontaneous release in vitro demands standardized sample processing. , 1993, Journal of immunological methods.

[42]  T. Haahtela,et al.  Eosinophil cationic protein in induced sputum as a marker of inflammation in asthmatic children , 1997, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[43]  Rp,et al.  Essential Chest Radiology , 1989 .

[44]  K. Dyer,et al.  Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. , 1996, Nucleic acids research.

[45]  T. Fukuda,et al.  Comparison between allergen-induced and exercise-induced asthma with respect to the late asthmatic response, airway responsiveness, and Creola bodies in sputum. , 1996, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[46]  J. D. de Monchy,et al.  Desensitization of the adenylyl cyclase system in peripheral blood mononuclear cells from patients with asthma three hours after allergen challenge. , 1993, The Journal of allergy and clinical immunology.

[47]  Moses Rodriguez,et al.  Localization of human eosinophil granule major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin by immunoelectron microscopy. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[48]  P. Barnes,et al.  Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. , 1997, American journal of respiratory and critical care medicine.

[49]  H. Boushey,et al.  Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. , 1993, The American review of respiratory disease.

[50]  M. Lindau,et al.  Focal exocytosis by eosinophils‐‐compound exocytosis and cumulative fusion. , 1993, The EMBO journal.

[51]  K. Dyer,et al.  Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. , 1995, Nucleic acids research.

[52]  R. Djukanović,et al.  Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum. , 1997, American journal of respiratory and critical care medicine.

[53]  I. Olsson,et al.  Localization of eosinophil cationic protein, major basic protein, and eosinophil peroxidase in human eosinophils by immunoelectron microscopic technique. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[54]  P. Venge,et al.  Secretion of granule proteins from eosinophils and neutrophils is increased in asthma. , 1991, The Journal of allergy and clinical immunology.

[55]  H. Rosenberg,et al.  Intronic Enhancer Activity of the Eosinophil-derived Neurotoxin (RNS2) and Eosinophil Cationic Protein (RNS3) Genes Is Mediated by an NFAT-1 Consensus Binding Sequence* , 1997, The Journal of Biological Chemistry.

[56]  K. Dyer,et al.  Rapid evolution of a unique family of primate ribonuclease genes , 1995, Nature Genetics.

[57]  I. Olsson,et al.  Mechanisms for eosinophil degranulation; release of the eosinophil cationic protein. , 1984, Immunology.

[58]  P. Venge,et al.  Schistosoma mansoni: further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro , 1984, Parasitology.

[59]  A. Ferguson,et al.  Correlation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma. , 1992, The Journal of allergy and clinical immunology.

[60]  P. Barnes,et al.  Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. , 1997, American journal of respiratory and critical care medicine.

[61]  P. Venge,et al.  Allergen-induced changes in nasal secretory responsiveness and eosinophil granulocytes. , 1991, Acta oto-laryngologica.

[62]  P. Montan,et al.  Eosinophil cationic protein in tears in allergic conjunctivitis. , 1996, The British journal of ophthalmology.

[63]  H. Kauffman,et al.  Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction. , 1993, The European respiratory journal.

[64]  P. Venge,et al.  Kinetic retrieval of eosinophil cationic protein, hyaluronan, secretory IgA, albumin, and urea during BAL in healthy subjects. , 1995, Chest.

[65]  M. Plebani,et al.  Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis , 1995, Allergy.

[66]  K. Dyer,et al.  Characterization of eosinophils generated in vitro from CD34+ peripheral blood progenitor cells. , 1996, Experimental hematology.

[67]  A. Tsuda,et al.  Eosinophil cationic protein induces insulin-like growth factor I receptor expression on bronchial epithelial cells. , 1996, International archives of allergy and immunology.

[68]  F. Hargreave,et al.  Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination. , 1996, The European respiratory journal.

[69]  W. Ryd,et al.  Activation of eosinophils and fibroblasts assessed by eosinophil cationic protein and hyaluronan in BAL. Association with acute rejection in lung transplant recipients. , 1996, Chest.

[70]  A. Miettinen,et al.  Intestinal inflammation in children with atopic eczema: faecal eosinophil cationic protein and tumour necrosis factor‐α as non‐invasive indicators of food allergy , 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[71]  J. Hermans,et al.  The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[72]  P. Sterk,et al.  Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. , 1996, The European respiratory journal.

[73]  G. Marone,et al.  Eosinophil granule proteins activate human heart mast cells. , 1996, Journal of immunology.

[74]  P. Venge,et al.  Degranulation of eosinophils from pollen-atopic patients with asthma is increased during pollen season. , 1992, The Journal of allergy and clinical immunology.

[75]  P. Venge,et al.  The eosinophil component of the alveolitis in idiopathic pulmonary fibrosis. Signs of eosinophil activation in the lung are related to impaired lung function. , 1989, The American review of respiratory disease.

[76]  H. Kita,et al.  Regulatory effect of cytokines on eosinophil degranulation. , 1990, Journal of immunology.

[77]  S. Abe,et al.  Eosinophilic cationic protein in chronic eosinophilic pneumonia and eosinophilic granuloma. , 1994, Chest.

[78]  B. Raghavender,et al.  Eosinophil cationic protein in tracheal aspirates of preterm infants with bronchopulmonary dysplasia. , 1997, The Journal of pediatrics.

[79]  S. Rutella,et al.  Immunophenotypic profile of peripheral blood eosinophils in acute graft-vs.-host disease. , 1998, Experimental hematology.

[80]  J. Bousquet,et al.  Eosinophilic inflammation in asthma. , 1990, The New England journal of medicine.

[81]  R. Dahl,et al.  Are blood eosinophil number and activity important for the development of the late asthmatic reaction after allergen challenge? , 1989, The European respiratory journal. Supplement.

[82]  H. Malech,et al.  Early commitment to the eosinophil lineage by cultured human peripheral blood CD34+ cells: messenger RNA analysis. , 1996, The Journal of allergy and clinical immunology.

[83]  M. de Waele,et al.  Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. , 1995, International archives of allergy and immunology.

[84]  K. Dyer,et al.  Eosinophil cationic protein and eosinophil-derived neurotoxin. Evolution of novel function in a primate ribonuclease gene family. , 1995, The Journal of biological chemistry.

[85]  A. Jansen,et al.  Effect of intranasal fluticasone proprionate on the immediate and late allergic reaction and nasal hyperreactivity in patients with a house dust mite allergy , 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[86]  G. Gürsel,et al.  Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease. , 1997, The Journal of asthma : official journal of the Association for the Care of Asthma.

[87]  F. Hargreave,et al.  Comparison of two methods of processing induced sputum: selected versus entire sputum. , 1998, American journal of respiratory and critical care medicine.

[88]  J. Kochan,et al.  Expression of the high-affinity immunoglobulin E receptor alpha-subunit in human blood eosinophils. , 1997, International Archives of Allergy and Immunology.

[89]  D. Loegering,et al.  Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[90]  A. Capron,et al.  Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation. , 1991, The Journal of allergy and clinical immunology.

[91]  A. Malmström,et al.  Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast cultures. , 1992, European journal of cell biology.

[92]  I. Olsson,et al.  Localization of granule proteins in human eosinophil bone marrow progenitors. , 1997, International archives of allergy and immunology.

[93]  K. Dyer,et al.  Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. , 1998, Nucleic acids research.

[94]  D. Koller,et al.  Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis. , 1995, American journal of respiratory and critical care medicine.

[95]  P. Venge,et al.  Mechanism of membrane damage mediated by human eosinophil cationic protein , 1986, Nature.

[96]  J. Denburg,et al.  Use of induced sputum cell counts to investigate airway inflammation in asthma. , 1992, Thorax.

[97]  G. Kreil.  Transfer of proteins across membranes. , 1981, Annual review of biochemistry.

[98]  T. Ganz,et al.  Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. , 1989, Journal of immunology.

[99]  P. Venge,et al.  Soluble markers of allergic inflammation , 1994, Allergy.

[100]  A. Dvorak,et al.  Cytokine induction of granule protein synthesis in an eosinophil‐inducible human myeloid cell line, AML14 , 1994, Journal of leukocyte biology.

[101]  B. Sander,et al.  Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure , 1991, Immunological reviews.

[102]  P. Venge,et al.  Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[103]  W. Sandborn,et al.  Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. , 1997, Mayo Clinic proceedings.

[104]  H. Kita,et al.  Localization of eosinophil‐derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes , 1998, Journal of leukocyte biology.

[105]  G. Rasp,et al.  Eosinophil inflammation of the nasal mucosa in allergic and non‐allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum , 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[106]  K. Ohuchi,et al.  Identification of cDNA encoding rat eosinophil cationic protein/eosinophil-associated ribonuclease. , 1997, Biochimica et biophysica acta.

[107]  T. Koob,et al.  N- and O-Linked Keratan Sulfate on the Hyaluronan Binding Region of Aggrecan from Mature and Immature Bovine Cartilage (*) , 1995, The Journal of Biological Chemistry.

[108]  R. Dahl,et al.  Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents. , 1989, The American journal of medicine.

[109]  H. Kita,et al.  Effect of steroids on immunoglobulin-induced eosinophil degranulation. , 1991, The Journal of allergy and clinical immunology.

[110]  S. Durham,et al.  Application of monoclonal antibodies against major basic protein (BMK‐13) and eosinophil cationic protein (EG1 and EG2) for quantifying eosinophils in bronchial biopsies from atopic asthma , 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[111]  T. Yoneda,et al.  Airway inflammation in COPD assessed by sputum levels of interleukin-8. , 1997, Chest.

[112]  I. Olsson,et al.  Monoclonal antibodies distinguish between storage and secreted forms of eosinophil cationic protein , 1984, Nature.

[113]  H. Kita,et al.  Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation. , 1991, Journal of immunology.

[114]  P. Venge,et al.  Releasability of human hypereosinophilic eosinophils is related to the density of the cells , 1994, British journal of haematology.

[115]  P. Venge,et al.  Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure. , 1990, The Journal of allergy and clinical immunology.

[116]  J. Bousquet,et al.  Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma. , 1991, The Journal of allergy and clinical immunology.

[117]  P. Venge,et al.  Eosinophils, secretory responsiveness and glucocorticoid‐induced effects on the nasal mucosa during a weak pollen season , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[118]  R. Naclerio,et al.  Mediator release after nasal airway challenge with allergen. , 2015, The American review of respiratory disease.

[119]  Spicer Ss,et al.  Cytochemical and ultrastructural identification of a small type granule in human late eosinophils. , 1974 .

[120]  P. Clement,et al.  Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. , 1994, Acta oto-laryngologica.

[121]  J. Lundahl,et al.  Eosinophil activity reflects clinical status in patients with asthma before and during a prednisolone course. , 1995, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[122]  P. Venge,et al.  Granulocytes and their secretory products, myeloperoxidase and eosinophil cationic protein, in bronchoalveolar lavage fluids from two lung lobes in normal subjects. , 1991, The European respiratory journal.

[123]  C. Kortsik,et al.  Comparison of sputum‐ECP levels in bronchial asthma and chronic bronchitis , 1993, Allergy.

[124]  M. Plebani,et al.  Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis , 1997, The British journal of ophthalmology.

[125]  T. Eberlein,et al.  Activation of eosinophils in cancer patients treated with IL-2 and IL-2-generated lymphokine-activated killer cells. , 1989, Journal of immunology.

[126]  M. Heise,et al.  Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. , 1990, Genomics.

[127]  R. Dahl,et al.  The Gordon phenomenon induced by the eosinophil cationic protein and eosinophil protein X. , 1982, The Journal of allergy and clinical immunology.

[128]  J. Bousquet,et al.  Correspondence and requests for reprints should be addressed to Jean Bousquet, , 2022 .

[129]  S. Oddera,et al.  Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild‐moderate, stable asthma , 1996, Allergy.

[130]  M. Nei,et al.  Positive Darwinian selection after gene duplication in primate ribonuclease genes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[131]  R. Duranti,et al.  Do sputum eosinophils and ECP relate to the severity of asthma? , 1997, The European respiratory journal.

[132]  A. Kay,et al.  Effects of rapamycin, cyclosporin A, and dexamethasone on interleukin 5‐induced eosinophil degranulation and prolonged survival , 1997, Allergy.

[133]  H. Boushey,et al.  Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. , 1994, The Journal of allergy and clinical immunology.