Common variation at 6 p 21 . 31 ( BAK 1 ) influences the risk of chronic lymphocytic leukemia *

*Susan L. Slager,1 *Christine F. Skibola,2 Maria Chiara Di Bernardo,3 Lucia Conde,2 Peter Broderick,3 Shannon K. McDonnell,1 Lynn R. Goldin,4 Naomi Croft,3 Amy Holroyd,3 Shelley Harris,3 Jacques Riby,2 Daniel J. Serie,1 Neil E. Kay,1 Timothy G. Call,1 Paige M. Bracci,5 Eran Halperin,6 Mark C. Lanasa,7 Julie M. Cunningham,1 Jose F. Leis,1 Vicki A. Morrison,8,9 Logan G. Spector,9 Celine M. Vachon,1 Tait D. Shanafelt,1 Sara S. Strom,10 Nicola J. Camp,11 J. Brice Weinberg,7,12 Estella Matutes,13 Neil E. Caporaso,4 Rachel Wade,14 Martin J. S. Dyer,15 Claire Dearden,13 James R. Cerhan,1 Daniel Catovsky,13 and Richard S. Houlston3

[1]  P. Broderick,et al.  Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk , 2011, British journal of haematology.

[2]  Celine M Vachon,et al.  Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. , 2011, Blood.

[3]  Simon C. Potter,et al.  The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study , 2011, PLoS genetics.

[4]  Kevin M. Brown,et al.  Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 , 2010, Nature Genetics.

[5]  E. Campo,et al.  Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk , 2010, Nature Genetics.

[6]  S. Kaufmann,et al.  Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis* , 2009, The Journal of Biological Chemistry.

[7]  Guy Pratt,et al.  A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia , 2008, Nature Genetics.

[8]  R. Wilkins Polygenes, risk prediction, and targeted prevention of breast cancer. , 2008, The New England journal of medicine.

[9]  T. Eisen,et al.  Bmc Cancer Identification of Low Penetrance Alleles for Lung Cancer: the Genetic Lung Cancer Predisposition Study (gelcaps) , 2008 .

[10]  D. George,et al.  Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. , 2007, Genes & development.

[11]  E. Papaemmanuil,et al.  National study of colorectal cancer genetics , 2007, British Journal of Cancer.

[12]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[13]  S. Korsmeyer,et al.  Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  K. Hemminki,et al.  Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. , 2004, Blood.

[15]  F. Stevenson,et al.  Chronic lymphocytic leukemia: revelations from the B-cell receptor. , 2004, Blood.

[16]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[17]  T J Hamblin,et al.  Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. , 1999, Blood.

[18]  G. Evan,et al.  Induction of apoptosis by the Bcl-2 homologue Bak , 1995, Nature.

[19]  N. Weiss Geographical variation in the incidence of the leukemias and lymphomas. , 1979, National Cancer Institute monograph.