The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals

Since GH stimulates lipolysis in vivo after a 2‐hr lag phase, we studied whether this involves GH signaling and gene expression in adipose tissue (AT).

[1]  J. Kopchick,et al.  Growth hormone controls lipolysis by regulation of FSP27 expression. , 2018, The Journal of endocrinology.

[2]  M. Birnbaum,et al.  The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin , 2015, Molecular and Cellular Biology.

[3]  A. Juul,et al.  GH signaling in skeletal muscle and adipose tissue in healthy human subjects: impact of gender and age. , 2014, European journal of endocrinology.

[4]  N. Møller,et al.  Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment. , 2014, The Journal of clinical endocrinology and metabolism.

[5]  N. Møller,et al.  Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. , 2014, Journal of molecular endocrinology.

[6]  R. T. Pickering,et al.  Fat-specific Protein 27 Inhibits Lipolysis by Facilitating the Inhibitory Effect of Transcription Factor Egr1 on Transcription of Adipose Triglyceride Lipase* , 2014, The Journal of Biological Chemistry.

[7]  N. Møller,et al.  Adipose Triglyceride Lipase and G0/G1 Switch Gene 2: Approaching Proof of Concept , 2014, Diabetes.

[8]  K. Thorsen,et al.  Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4 , 2013, Journal of Lipid Research.

[9]  A. Friedl,et al.  Stain-Free technology as a normalization tool in Western blot analysis. , 2013, Analytical biochemistry.

[10]  C. Kahn,et al.  Lessons on Conditional Gene Targeting in Mouse Adipose Tissue , 2013, Diabetes.

[11]  A. Bartke,et al.  The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. , 2013, Molecular endocrinology.

[12]  Y. Tamori,et al.  FSP27 Promotes Lipid Droplet Clustering and Then Fusion to Regulate Triglyceride Accumulation , 2011, PloS one.

[13]  C. Kahn,et al.  The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation. , 2011, Cell metabolism.

[14]  M. Vendelbo,et al.  Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue. , 2011, The Journal of clinical endocrinology and metabolism.

[15]  M. Cowley,et al.  Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: a gene expression study in hypopituitary men. , 2011, The Journal of clinical endocrinology and metabolism.

[16]  Xin Lu,et al.  The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. , 2010, Cell metabolism.

[17]  Niels Møller,et al.  Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. , 2009, Endocrine reviews.

[18]  A. Chawla,et al.  Fat-specific Protein 27, a Novel Lipid Droplet Protein That Enhances Triglyceride Storage* , 2007, Journal of Biological Chemistry.

[19]  M. Jensen,et al.  Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics. , 2007, American journal of physiology. Endocrinology and metabolism.

[20]  C. Kahn,et al.  Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.

[21]  V. Large,et al.  Metabolism of lipids in human white adipocyte. , 2004, Diabetes & metabolism.

[22]  T. Graham,et al.  Dexras1 inhibits adenylyl cyclase. , 2004, Biochemical and biophysical research communications.

[23]  M. Jensen,et al.  Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men. , 2004, Journal of applied physiology.

[24]  K. Nair,et al.  Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients. , 2003, American journal of physiology. Endocrinology and metabolism.

[25]  E. Reiter,et al.  Growth hormone , 1993 .

[26]  J. Bülow,et al.  Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. , 1999, American journal of physiology. Endocrinology and metabolism.

[27]  R. Kemppainen,et al.  Dexamethasone Rapidly Induces a Novel Ras Superfamily Member-related Gene in AtT-20 Cells* , 1998, The Journal of Biological Chemistry.

[28]  M Lafontan,et al.  Fat cell adrenergic receptors and the control of white and brown fat cell function. , 1993, Journal of lipid research.

[29]  K. Alberti,et al.  Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. , 1990, The Journal of clinical endocrinology and metabolism.

[30]  R. Wolfe,et al.  Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. , 1987, The American journal of physiology.

[31]  F. Matsuzaki,et al.  Growth hormone. 1. Physiologic aspects. , 1962, The New England journal of medicine.

[32]  M. Vendelbo,et al.  Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes. , 2019, American journal of physiology. Endocrinology and metabolism.

[33]  M. Waters,et al.  GH does not modulate the early fasting-induced release of free fatty acids in mice. , 2012, Endocrinology.

[34]  M. Jensen,et al.  Insulin dose response analysis of free fatty acid kinetics. , 2007, Metabolism: clinical and experimental.

[35]  E. Degerman,et al.  Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B. , 1998, Methods.

[36]  K. Alberti,et al.  Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. , 1990, The American journal of physiology.