Experimental Modification of the Rat Pineal's Content of Serotonin and Related Indole Amines

lian pineal gland first attracted attention when Lerner and co-workers (1958, 1959a, 1959b) extracted N-acetyl-5-methoxytryptamine from bovine pineals. This compound they called melatonin and demonstrated for it a hormonal action on frog melanocytes. Melatonin was found to be approximately 105 times as potent as noradrenaline in causing aggregation of melanin granules in amphibian melanocytes. Although it was shown that melatonin occurs in small amounts in bovine and human

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