Block of GABAA receptor ion channel by penicillin: Electrophysiological and modeling insights toward the mechanism

[1]  P. Herson,et al.  Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1‐subunit‐containing receptors , 2013, The European journal of neuroscience.

[2]  T. Smart,et al.  Binding, activation and modulation of Cys-loop receptors. , 2010, Trends in pharmacological sciences.

[3]  Marc Baaden,et al.  Atomic structure and dynamics of pentameric ligand‐gated ion channels: new insight from bacterial homologues , 2010, The Journal of physiology.

[4]  Boris S. Zhorov,et al.  Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function , 2010, J. Comput. Aided Mol. Des..

[5]  Brian E. Erkkila,et al.  Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin. , 2008, Biophysical journal.

[6]  M. Akabas,et al.  The Location of a Closed Channel Gate in the GABAA Receptor Channel , 2007, The Journal of general physiology.

[7]  Brian E. Erkkila,et al.  Stoichiometry of a pore mutation that abolishes picrotoxin‐mediated antagonism of the GABAA receptor , 2006, The Journal of physiology.

[8]  M. Cascio Modulating inhibitory ligand-gated ion channels , 2006, The AAPS Journal.

[9]  R. Olsen Picrotoxin-like channel blockers of GABAA receptors. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Grissmer,et al.  Interaction of d-Tubocurarine with Potassium Channels: Molecular Modeling and Ligand Binding , 2006, Molecular Pharmacology.

[11]  Kathleen A. Durkin,et al.  Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  K. Chow,et al.  Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside , 2005, European Journal of Clinical Microbiology and Infectious Diseases.

[13]  Shin-Ho Chung,et al.  Homology model of the GABAA receptor examined using Brownian dynamics. , 2005, Biophysical journal.

[14]  N. Unwin,et al.  Refined structure of the nicotinic acetylcholine receptor at 4A resolution. , 2005, Journal of molecular biology.

[15]  Peter R Schofield,et al.  Ligand-gated ion channels: mechanisms underlying ion selectivity. , 2004, Progress in biophysics and molecular biology.

[16]  K. Wafford,et al.  The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. , 2004, Biochemical Society transactions.

[17]  Y. Fujiyoshi,et al.  Structure and gating mechanism of the acetylcholine receptor pore , 2003, Nature.

[18]  V. Skrebitsky,et al.  Mechanisms of GABAA receptor blockade by millimolar concentrations of furosemide in isolated rat Purkinje cells , 2002, Neuropharmacology.

[19]  T. Mashimo,et al.  The β‐lactam antibiotics, penicillin‐G and cefoselis have different mechanisms and sites of action at GABAA receptors , 2002 .

[20]  K. Fuchs,et al.  Two Novel Residues in M2 of the γ-Aminobutyric Acid Type A Receptor Affecting Gating by GABA and Picrotoxin Affinity* , 2001, The Journal of Biological Chemistry.

[21]  A. Sobolevsky Quantitative analysis of tetrapentylammonium-induced blockade of open N-methyl-D-aspartate channels. , 2000, Biophysical journal.

[22]  A. Sobolevsky,et al.  Probing of NMDA Channels with Fast Blockers , 1999, The Journal of Neuroscience.

[23]  G. Westbrook,et al.  Defining Affinity with the GABAA Receptor , 1998, The Journal of Neuroscience.

[24]  W. Hevers,et al.  The diversity of GABAA receptors , 1998, Molecular Neurobiology.

[25]  H. Haas,et al.  A simple perfusion system for patch-clamp studies , 1996, Journal of Neuroscience Methods.

[26]  S. Antonov,et al.  Voltage‐dependent interaction of open‐channel blocking molecules with gating of NMDA receptors in rat cortical neurons. , 1996, The Journal of physiology.

[27]  R. Mckernan,et al.  Which GABAA-receptor subtypes really occur in the brain? , 1996, Trends in Neurosciences.

[28]  N. Akaike,et al.  Dual mechanisms of GABAa response inhibition by β‐lactam antibiotics in the pyramidal neurones of the rat cerebral cortex , 1995, British journal of pharmacology.

[29]  Donald B. Carter,et al.  Enhancement by GABA of the association rate of picrotoxin and tert‐butylbicyclophosphorothionate to the rat cloned α1β2γ2 GABAA receptor subtype , 1995 .

[30]  M. Mayer,et al.  Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine. , 1995, The Journal of physiology.

[31]  R. ffrench-Constant,et al.  A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms. , 1994, The Journal of physiology.

[32]  I. Sharonova,et al.  Tetrahydroaminoacridine blocks and prolongs NMDA receptor-mediated responses in a voltage-dependent manner. , 1994, European journal of pharmacology.

[33]  R. ffrench-Constant,et al.  A point mutation in a Drosophila GABA receptor confers insecticide resistance , 1993, Nature.

[34]  D. Covey,et al.  Multiple mechanisms of picrotoxin block of GABA‐induced currents in rat hippocampal neurons. , 1993, The Journal of physiology.

[35]  W Wisden,et al.  The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[36]  Jean-Luc Galzi,et al.  Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic , 1992, Nature.

[37]  C. Newland,et al.  On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. , 1992, The Journal of physiology.

[38]  CE Jahr,et al.  NMDA channel behavior depends on agonist affinity , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[39]  Vladimir S. Vorobjev,et al.  Vibrodissociation of sliced mammalian nervous tissue , 1991, Journal of Neuroscience Methods.

[40]  H. Betz Ligand-gated ion channels in the brain: The amino acid receptor superfamily , 1990, Neuron.

[41]  H. Scheraga,et al.  Monte Carlo-minimization approach to the multiple-minima problem in protein folding. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[42]  D. Mathers,et al.  Convulsant doses of penicillin shorten the lifetime of GABA‐induced channels in cultured central neurones , 1986, British journal of pharmacology.

[43]  Eamonn F. Healy,et al.  Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model , 1985 .

[44]  U. Singh,et al.  A NEW FORCE FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC ACIDS AND PROTEINS , 1984 .

[45]  E Neher,et al.  The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics. , 1983, The Journal of physiology.

[46]  B. Sakmann,et al.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches , 1981, Pflügers Archiv.

[47]  H. Pickles,et al.  Antagonism by penicillin of γ-aminobutyric acid depolarizations at presynaptic sites in rat olfactory cortex and cuneate nucleus in vitro , 1980, Neuropharmacology.

[48]  P. Ascher,et al.  Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells. , 1979, The Journal of physiology.

[49]  E. Neher,et al.  Local anaesthetics transiently block currents through single acetylcholine‐receptor channels. , 1978, The Journal of physiology.

[50]  P. Adams Drug blockade of open end‐plate channels. , 1976, The Journal of physiology.

[51]  A. Woodhull,et al.  Ionic Blockage of Sodium Channels in Nerve , 1973, The Journal of general physiology.

[52]  D. R. Curtis,et al.  Convulsive action of penicillin. , 1972, Brain research.

[53]  J. Changeux,et al.  X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation , 2009, Nature.

[54]  W. Sieghart Structure, pharmacology, and function of GABAA receptor subtypes. , 2006, Advances in pharmacology.

[55]  R. Twyman,et al.  Kinetics of open channel block by penicillin of single GABAA receptor channels from mouse spinal cord neurones in culture. , 1992, The Journal of physiology.

[56]  H. Betz,et al.  Lkand-Gated Ion Channels in the Brain: Review Thee Amino Acid Receptor Superfamily , 1990 .

[57]  B. Montgomery Pettitt,et al.  Structural and energetic effects of truncating long ranged interactions in ionic and polar fluids , 1985 .