Misconnections in the Critically Ill: Injection of High-Dose Gadolinium into an External Ventricular Drain.

We report an unfortunate case of accidental administration of intrathecal gadolinium through an external ventricular drain in a postcraniotomy patient during magnetic resonance imaging of the brain. The incident occurred after the venous contrast line was connected mistakenly to the ventricular drainage catheter. The patient subsequently developed confusion, aphasia, and right facial droop with new computed tomography evidence of diffuse cerebral edema and stroke. Review of the magnetic resonance image revealed the inappropriate presence of subarachnoid gadolinium. Despite all interventions, the patient developed irreversible neurologic disability. We address the clinical sequelae, management strategies, and factors contributing to the catheter misconnection that led to this event.

[1]  B. Turkbey,et al.  Intrathecal Gadolinium-Enhanced MR Cisternography: A Comprehensive Review , 2013, American Journal of Neuroradiology.

[2]  C. Vincent,et al.  A matter of conscience: a call to action for system improvements involving epidural and spinal catheters. , 2012, Anesthesia and analgesia.

[3]  Jiabin Liu,et al.  Gadolinium encephalopathy after intrathecal gadolinium injection. , 2010, Pain physician.

[4]  Kui Wang,et al.  Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity. , 2010, Neurotoxicology.

[5]  Sun-Chul Hwang,et al.  Neurotoxic Manifestations of an Overdose Intrathecal Injection of Gadopentetate Dimeglumine , 2010, Journal of Korean medical science.

[6]  K. Mohseni,et al.  Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia. , 2009, Anesthesia and analgesia.

[7]  J. Zhao,et al.  Overdosage of intrathecal gadolinium and neurological response. , 2008, Clinical radiology.

[8]  S. Howell,et al.  Unintentional intracerebroventricular administration of etomidate and rocuronium. , 2008, Anesthesia and analgesia.

[9]  S. Arlt,et al.  Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine , 2007, Journal of Neurology.

[10]  J. Drake,et al.  Near-miss Injection of an Anesthetic Agent into a Cerebrospinal Fluid External Ventricular Drain: Special Report , 2005, Neurosurgery.

[11]  E. Wijdicks,et al.  Gadolinium encephalopathy in a patient with renal failure , 2005, Neurology.

[12]  A. Mironov,et al.  Intrathecal Gadolinium (Gadopentetate Dimeglumine) Enhanced Magnetic Resonance Myelography and Cisternography: Results of a Multicenter Study , 2002, Investigative radiology.

[13]  K. Uehara,et al.  [Analysis of inadvertent epidural injection of drugs]. , 2000, Masui. The Japanese journal of anesthesiology.