ZnO and Hydroxyapatite-Modified Magnesium Implant with a Broad Spectrum of Antibacterial Properties and a Unique Minimally Invasive Defined Degrading Capability.

ZnO and hydroxyapatite-based membranes have been proposed to improve the antibacterial properties and anticorrosion capabilities of the magnesium implant, simultaneously. More importantly, the concept of minimally invasive surgery has been introduced to define the degradation timing of the as-modified magnesium implant. With the aid of a Kirschner wire, the as-prepared membrane could immediately change from the "protective layer" to the "degradation accelerator" of the implant material. The subsequent studies have implied that this membrane could be a promising avenue to create a biocompatible and lightweight implant material with a valuable personal customized degradable timing capability.

[1]  W. Lu,et al.  Enhancing Corrosion Resistance, Osteoinduction, and Antibacterial Properties by Zn/Sr Additional Surface Modification of Magnesium Alloy. , 2018, ACS biomaterials science & engineering.

[2]  W. Ding,et al.  Modeling and Experimental Studies of Coating Delamination of Biodegradable Magnesium Alloy Cardiovascular Stents. , 2018, ACS biomaterials science & engineering.

[3]  W. Walsh,et al.  The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant. , 2018, The spine journal : official journal of the North American Spine Society.

[4]  Yufeng Zheng,et al.  In Vitro and in Vivo Studies on Biomedical Magnesium Low-Alloying with Elements Gadolinium and Zinc for Orthopedic Implant Applications. , 2018, ACS applied materials & interfaces.

[5]  Xigao Cheng,et al.  "Dandelion" Inspired Dual-Layered Nanoarrays with Two Model Releasing Features for the Surface Modification of 3D Printing Implants. , 2017, ACS biomaterials science & engineering.

[6]  Changli Zhao,et al.  Development of PLA/Mg composite for orthopedic implant: Tunable degradation and enhanced mineralization , 2017 .

[7]  Ke Yang,et al.  In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles , 2017 .

[8]  Xigao Cheng,et al.  Falling Leaves Inspired ZnO Nanorods-Nanoslices Hierarchical Structure for Implant Surface Modification with Two Stage Releasing Features. , 2017, ACS applied materials & interfaces.

[9]  X. Cui,et al.  Poly (3,4-ethylenedioxythiophene) graphene oxide composite coatings for controlling magnesium implant corrosion. , 2017, Acta biomaterialia.

[10]  Frank Witte,et al.  Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective. , 2017, Biomaterials.

[11]  Yufeng Zheng,et al.  Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats , 2016, Nature Medicine.

[12]  Richard C. Gerum,et al.  Cell Adhesion on Surface-Functionalized Magnesium. , 2016, ACS applied materials & interfaces.

[13]  S. Lee,et al.  Reduction of initial corrosion rate and improvement of cell adhesion through surface modification of biodegradable Mg alloy , 2015, Metals and Materials International.

[14]  Savio L-Y Woo,et al.  Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering. , 2014, Journal of biomechanics.

[15]  Jun Ma,et al.  Similarities and differences in coatings for magnesium-based stents and orthopaedic implants , 2014, Journal of orthopaedic translation.

[16]  R. G. Richards,et al.  Bacterial adhesion to orthopaedic implant materials and a novel oxygen plasma modified PEEK surface. , 2014, Colloids and surfaces. B, Biointerfaces.

[17]  W. Ding,et al.  Enhanced biocorrosion resistance and biocompatibility of degradable Mg-Nd-Zn-Zr alloy by brushite coating. , 2013, Materials science & engineering. C, Materials for biological applications.

[18]  M. Niinomi,et al.  Development of new metallic alloys for biomedical applications. , 2012, Acta biomaterialia.

[19]  A. Gedanken,et al.  Improved antibacterial and antibiofilm activity of magnesium fluoride nanoparticles obtained by water-based ultrasound chemistry. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[20]  P. Uggowitzer,et al.  On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg-Y-Zn alloys. , 2010, Acta biomaterialia.

[21]  Duane A Robinson,et al.  In vitro antibacterial properties of magnesium metal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. , 2010, Acta biomaterialia.

[22]  S. Hiromoto,et al.  High corrosion resistance of magnesium coated with hydroxyapatite directly synthesized in an aqueous solution , 2009 .

[23]  A. Singh,et al.  Ti based biomaterials, the ultimate choice for orthopaedic implants – A review , 2009 .

[24]  Chengtie Wu,et al.  Novel sphene coatings on Ti-6Al-4V for orthopedic implants using sol-gel method. , 2008, Acta biomaterialia.

[25]  S. Kurtz,et al.  PEEK biomaterials in trauma, orthopedic, and spinal implants. , 2007, Biomaterials.

[26]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[27]  J. Mandrekar,et al.  Outcome of prosthetic joint infection in patients with rheumatoid arthritis: the impact of medical and surgical therapy in 200 episodes. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  W. Lanford,et al.  Interface reaction/diffusion in hydroxylapatite-coated SS316L and CoCrMo alloys , 2004 .