Multiscale modeling and validation of particulate processes

OF THE DISSERTATION MULTISCALE MODELING AND VALIDATION OF PARTICULATE PROCESSES by MAITRAYE SEN Dissertation Director: Dr. Rohit Ramachandran Since solid handling and processing have a wide application in many chemical and pharmaceutical industries, it is important to understand the powder dynamics. The objective of this work is to build multiscale models (with the aid of different modeling techniques; PBM (population balance model), DEM (discrete element model) and CFD (computational fluid dynamics) for various solid/powder handling operations and design an integrated flowsheet model connecting the continuous API (active pharmaceutical ingredient) purification/processing and downstream tablet manufacturing operations (as applicable in case of pharmaceutical industries). At present there is no existing link between the API processing and purification and downstream tablet manufacturing operation. However it has been seen that the physical properties of API (size, shape etc.) have considerable effect on the critical quality attributes (CQAs) of the product obtained from the downstream tablet manufacturing operations. Therefore, such a flowsheet will allow a detailed study of the effect of upstream (API purification and processing) process parameters on the downstream (tablet manufacturing) product attributes. A multiscale modeling approach has been adapted in order to develop a novel PBM for powder mixing (an important unit operation in tablet manufacturing framework),

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