Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis
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T. Köcher | R. Zinzen | H. Esterbauer | J. Knoblich | Robert P. Zinzen | Lisa Landskron | V. Steinmann | François Bonnay | Merve Deniz Abdusselamoglu | Sunanjay Bajaj | A. Veloso | Elisa Rivelles | Victoria Steinmann
[1] A. Brand,et al. Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation , 2019, eLife.
[2] Peng Zhang,et al. AIF-regulated oxidative phosphorylation supports lung cancer development , 2019, Cell Research.
[3] G. Patti,et al. Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation , 2019, eLife.
[4] H. Christofk,et al. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin , 2019, Nature Communications.
[5] S. Javadov,et al. Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria , 2018, Scientific Reports.
[6] R. Deberardinis,et al. Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. , 2018, Cell metabolism.
[7] Z. Werb,et al. Tumour heterogeneity and metastasis at single-cell resolution , 2018, Nature Cell Biology.
[8] Altuna Akalin,et al. PiGx: reproducible genomics analysis pipelines with GNU Guix , 2018, GigaScience.
[9] J. Gorodkin,et al. Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer , 2018, Current Biology.
[10] J. Graff,et al. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11 , 2018, Communications Biology.
[11] A. Brand,et al. Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence , 2018, Science.
[12] Paul Hoffman,et al. Integrating single-cell transcriptomic data across different conditions, technologies, and species , 2018, Nature Biotechnology.
[13] H. Reichert,et al. The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells , 2018, eLife.
[14] F. Sotgia,et al. Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling , 2018, Oncotarget.
[15] G. Meister,et al. The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda , 2018, EMBO reports.
[16] D. Barber,et al. Cell fate decisions: emerging roles for metabolic signals and cell morphology , 2017, EMBO reports.
[17] Joshua D. Rabinowitz,et al. Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.
[18] Jamey D. Young,et al. Lactate Metabolism in Human Lung Tumors , 2017, Cell.
[19] Eyal Gottlieb,et al. Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells , 2017, Nature Medicine.
[20] Ruth Beckervordersandforth,et al. Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis , 2017, Brain plasticity.
[21] T. Copetti,et al. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. , 2016, Cancer cell.
[22] E. Gottlieb,et al. A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis , 2016, Cancer & Metabolism.
[23] U. Banerjee,et al. In vivo genetic dissection of tumor growth and the Warburg effect , 2016, eLife.
[24] J. Loscalzo,et al. In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state , 2016, Nature Protocols.
[25] O. Kretz,et al. Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.
[26] Navdeep S. Chandel,et al. Fundamentals of cancer metabolism , 2016, Science Advances.
[27] Z. Ronai,et al. Regulators of mitochondrial dynamics in cancer. , 2016, Current opinion in cell biology.
[28] Prashant Mishra,et al. Metabolic regulation of mitochondrial dynamics , 2016, The Journal of cell biology.
[29] E. Knudsen,et al. Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities. , 2016, Cell reports.
[30] Mark A Feitelson,et al. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. , 2015, Seminars in cancer biology.
[31] C. Klämbt,et al. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. , 2015, Cell metabolism.
[32] M. V. Heiden,et al. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.
[33] L. Solt,et al. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. , 2015, Cancer cell.
[34] D. Sabatini,et al. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.
[35] M. Hottiger. Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics. , 2015, Annual review of biochemistry.
[36] R. Deberardinis,et al. Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases , 2014, Cell.
[37] Thomas R. Burkard,et al. Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells , 2014, Cell.
[38] Giulia Guzzo,et al. Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation , 2014, Oncotarget.
[39] H. Reichert,et al. Drosophila Neural Stem Cells in Brain Development and Tumor Formation , 2014, Journal of neurogenetics.
[40] Cole Trapnell,et al. Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions , 2014, Nature Biotechnology.
[41] H. Reichert,et al. SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells , 2014, Cell.
[42] L. Johnston,et al. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. , 2014, Cell metabolism.
[43] B. Lu,et al. Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway , 2013, Genes & development.
[44] Kaleigh Fernald,et al. Evading apoptosis in cancer. , 2013, Trends in cell biology.
[45] Abhishek K. Jha,et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. , 2013, Cancer cell.
[46] J. Skotheim,et al. Control of cell cycle transcription during G1 and S phases , 2013, Nature Reviews Molecular Cell Biology.
[47] B. Van Houten,et al. Metabolic symbiosis in cancer: Refocusing the Warburg lens , 2013, Molecular carcinogenesis.
[48] Jun S. Song,et al. Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.
[49] P. Puigserver,et al. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. , 2013, Cancer cell.
[50] J. Knoblich,et al. Drosophila neuroblasts: a model for stem cell biology , 2012, Development.
[51] Corey Kelsom,et al. Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis , 2012, Cell & Bioscience.
[52] Nicolò Riggi,et al. Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. , 2012, Genes & development.
[53] David Attwell,et al. Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing , 2012, The Journal of Neuroscience.
[54] C. Delidakis,et al. bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation , 2012, Development.
[55] S. Thor,et al. Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression , 2012, Development.
[56] Y. Jan,et al. Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains , 2011, Proceedings of the National Academy of Sciences.
[57] J. Shay,et al. Role of telomeres and telomerase in cancer. , 2011, Seminars in cancer biology.
[58] R. Youle,et al. Coupling mitochondrial and cell division , 2011, Nature Cell Biology.
[59] X. Bian,et al. Mitochondrial and energy metabolism‐related properties as novel indicators of lung cancer stem cells , 2011, International journal of cancer.
[60] Juergen A. Knoblich,et al. Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi , 2011, Cell stem cell.
[61] Benedikt Westermann,et al. Mitochondrial fusion and fission in cell life and death , 2010, Nature Reviews Molecular Cell Biology.
[62] Juergen A. Knoblich,et al. Asymmetric cell division: recent developments and their implications for tumour biology , 2010, Nature Reviews Molecular Cell Biology.
[63] H. Jacobs,et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction , 2010, Proceedings of the National Academy of Sciences.
[64] J. Sage,et al. Cellular mechanisms of tumour suppression by the retinoblastoma gene , 2008, Nature Reviews Cancer.
[65] Chris Q Doe,et al. Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells , 2008, Developmental neurobiology.
[66] S. Bowman,et al. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. , 2008, Developmental cell.
[67] D. Featherstone,et al. Hemolymph amino acid analysis of individual Drosophila larvae. , 2008, Analytical chemistry.
[68] H. Reichert,et al. Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development , 2008, Neural Development.
[69] R. Deberardinis,et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.
[70] Tzumin Lee,et al. Gradients of the Drosophila Chinmo BTB-Zinc Finger Protein Govern Neuronal Temporal Identity , 2006, Cell.
[71] K. Mechtler,et al. Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells , 2006, Cell.
[72] E. Caussinus,et al. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster , 2005, Nature Genetics.
[73] C. Doe,et al. Drosophila neuroblast 7‐3 cell lineage: A model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity , 2005, The Journal of comparative neurology.
[74] Rodrigue Rossignol,et al. Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells , 2004, Cancer Research.
[75] Ronald L. Davis,et al. Spatiotemporal Rescue of Memory Dysfunction in Drosophila , 2003, Science.
[76] Michael W. Young,et al. vrille, Pdp1, and dClock Form a Second Feedback Loop in the Drosophila Circadian Clock , 2003, Cell.
[77] Steven F. Dowdy,et al. Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes , 2002 .
[78] G. Tear,et al. Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. , 1998, Genes & development.
[79] P. O’Farrell,et al. The transcription factor E2F is required for S phase during Drosophila embryogenesis. , 1995, Genes & development.
[80] Y. Jan,et al. asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. , 1993, Development.
[81] Y. Jan,et al. The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. , 1993, Development.
[82] S. Weinhouse. On respiratory impairment in cancer cells. , 1956, Science.
[83] O. Warburg,et al. THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.