Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

[1]  A. Brand,et al.  Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation , 2019, eLife.

[2]  Peng Zhang,et al.  AIF-regulated oxidative phosphorylation supports lung cancer development , 2019, Cell Research.

[3]  G. Patti,et al.  Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation , 2019, eLife.

[4]  H. Christofk,et al.  Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin , 2019, Nature Communications.

[5]  S. Javadov,et al.  Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria , 2018, Scientific Reports.

[6]  R. Deberardinis,et al.  Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. , 2018, Cell metabolism.

[7]  Z. Werb,et al.  Tumour heterogeneity and metastasis at single-cell resolution , 2018, Nature Cell Biology.

[8]  Altuna Akalin,et al.  PiGx: reproducible genomics analysis pipelines with GNU Guix , 2018, GigaScience.

[9]  J. Gorodkin,et al.  Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer , 2018, Current Biology.

[10]  J. Graff,et al.  Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11 , 2018, Communications Biology.

[11]  A. Brand,et al.  Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence , 2018, Science.

[12]  Paul Hoffman,et al.  Integrating single-cell transcriptomic data across different conditions, technologies, and species , 2018, Nature Biotechnology.

[13]  H. Reichert,et al.  The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells , 2018, eLife.

[14]  F. Sotgia,et al.  Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling , 2018, Oncotarget.

[15]  G. Meister,et al.  The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda , 2018, EMBO reports.

[16]  D. Barber,et al.  Cell fate decisions: emerging roles for metabolic signals and cell morphology , 2017, EMBO reports.

[17]  Joshua D. Rabinowitz,et al.  Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.

[18]  Jamey D. Young,et al.  Lactate Metabolism in Human Lung Tumors , 2017, Cell.

[19]  Eyal Gottlieb,et al.  Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells , 2017, Nature Medicine.

[20]  Ruth Beckervordersandforth,et al.  Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis , 2017, Brain plasticity.

[21]  T. Copetti,et al.  Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. , 2016, Cancer cell.

[22]  E. Gottlieb,et al.  A rapid method for quantifying free and bound acetate based on alkylation and GC-MS analysis , 2016, Cancer & Metabolism.

[23]  U. Banerjee,et al.  In vivo genetic dissection of tumor growth and the Warburg effect , 2016, eLife.

[24]  J. Loscalzo,et al.  In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD+/NADH redox state , 2016, Nature Protocols.

[25]  O. Kretz,et al.  Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.

[26]  Navdeep S. Chandel,et al.  Fundamentals of cancer metabolism , 2016, Science Advances.

[27]  Z. Ronai,et al.  Regulators of mitochondrial dynamics in cancer. , 2016, Current opinion in cell biology.

[28]  Prashant Mishra,et al.  Metabolic regulation of mitochondrial dynamics , 2016, The Journal of cell biology.

[29]  E. Knudsen,et al.  Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities. , 2016, Cell reports.

[30]  Mark A Feitelson,et al.  Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. , 2015, Seminars in cancer biology.

[31]  C. Klämbt,et al.  Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. , 2015, Cell metabolism.

[32]  M. V. Heiden,et al.  Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.

[33]  L. Solt,et al.  Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. , 2015, Cancer cell.

[34]  D. Sabatini,et al.  An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.

[35]  M. Hottiger Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics. , 2015, Annual review of biochemistry.

[36]  R. Deberardinis,et al.  Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases , 2014, Cell.

[37]  Thomas R. Burkard,et al.  Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells , 2014, Cell.

[38]  Giulia Guzzo,et al.  Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation , 2014, Oncotarget.

[39]  H. Reichert,et al.  Drosophila Neural Stem Cells in Brain Development and Tumor Formation , 2014, Journal of neurogenetics.

[40]  Cole Trapnell,et al.  Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions , 2014, Nature Biotechnology.

[41]  H. Reichert,et al.  SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells , 2014, Cell.

[42]  L. Johnston,et al.  Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. , 2014, Cell metabolism.

[43]  B. Lu,et al.  Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway , 2013, Genes & development.

[44]  Kaleigh Fernald,et al.  Evading apoptosis in cancer. , 2013, Trends in cell biology.

[45]  Abhishek K. Jha,et al.  Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. , 2013, Cancer cell.

[46]  J. Skotheim,et al.  Control of cell cycle transcription during G1 and S phases , 2013, Nature Reviews Molecular Cell Biology.

[47]  B. Van Houten,et al.  Metabolic symbiosis in cancer: Refocusing the Warburg lens , 2013, Molecular carcinogenesis.

[48]  Jun S. Song,et al.  Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.

[49]  P. Puigserver,et al.  PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. , 2013, Cancer cell.

[50]  J. Knoblich,et al.  Drosophila neuroblasts: a model for stem cell biology , 2012, Development.

[51]  Corey Kelsom,et al.  Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis , 2012, Cell & Bioscience.

[52]  Nicolò Riggi,et al.  Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. , 2012, Genes & development.

[53]  David Attwell,et al.  Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing , 2012, The Journal of Neuroscience.

[54]  C. Delidakis,et al.  bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation , 2012, Development.

[55]  S. Thor,et al.  Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression , 2012, Development.

[56]  Y. Jan,et al.  Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains , 2011, Proceedings of the National Academy of Sciences.

[57]  J. Shay,et al.  Role of telomeres and telomerase in cancer. , 2011, Seminars in cancer biology.

[58]  R. Youle,et al.  Coupling mitochondrial and cell division , 2011, Nature Cell Biology.

[59]  X. Bian,et al.  Mitochondrial and energy metabolism‐related properties as novel indicators of lung cancer stem cells , 2011, International journal of cancer.

[60]  Juergen A. Knoblich,et al.  Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi , 2011, Cell stem cell.

[61]  Benedikt Westermann,et al.  Mitochondrial fusion and fission in cell life and death , 2010, Nature Reviews Molecular Cell Biology.

[62]  Juergen A. Knoblich,et al.  Asymmetric cell division: recent developments and their implications for tumour biology , 2010, Nature Reviews Molecular Cell Biology.

[63]  H. Jacobs,et al.  Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction , 2010, Proceedings of the National Academy of Sciences.

[64]  J. Sage,et al.  Cellular mechanisms of tumour suppression by the retinoblastoma gene , 2008, Nature Reviews Cancer.

[65]  Chris Q Doe,et al.  Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells , 2008, Developmental neurobiology.

[66]  S. Bowman,et al.  The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. , 2008, Developmental cell.

[67]  D. Featherstone,et al.  Hemolymph amino acid analysis of individual Drosophila larvae. , 2008, Analytical chemistry.

[68]  H. Reichert,et al.  Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development , 2008, Neural Development.

[69]  R. Deberardinis,et al.  Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.

[70]  Tzumin Lee,et al.  Gradients of the Drosophila Chinmo BTB-Zinc Finger Protein Govern Neuronal Temporal Identity , 2006, Cell.

[71]  K. Mechtler,et al.  Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells , 2006, Cell.

[72]  E. Caussinus,et al.  Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster , 2005, Nature Genetics.

[73]  C. Doe,et al.  Drosophila neuroblast 7‐3 cell lineage: A model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity , 2005, The Journal of comparative neurology.

[74]  Rodrigue Rossignol,et al.  Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells , 2004, Cancer Research.

[75]  Ronald L. Davis,et al.  Spatiotemporal Rescue of Memory Dysfunction in Drosophila , 2003, Science.

[76]  Michael W. Young,et al.  vrille, Pdp1, and dClock Form a Second Feedback Loop in the Drosophila Circadian Clock , 2003, Cell.

[77]  Steven F. Dowdy,et al.  Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes , 2002 .

[78]  G. Tear,et al.  Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. , 1998, Genes & development.

[79]  P. O’Farrell,et al.  The transcription factor E2F is required for S phase during Drosophila embryogenesis. , 1995, Genes & development.

[80]  Y. Jan,et al.  asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. , 1993, Development.

[81]  Y. Jan,et al.  The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. , 1993, Development.

[82]  S. Weinhouse On respiratory impairment in cancer cells. , 1956, Science.

[83]  O. Warburg,et al.  THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.