Image Reconstruction in Photoacoustic Computed Tomography with Acoustically Heterogeneous Media

OF THE DISSERTATION Image Reconstruction in Photoacoustic Computed Tomography with Acoustically Heterogeneous Media by Chao Huang Doctor of Philosophy in Biomedical Engineering Washington University in St. Louis, August 2014 Professor Mark Anastasio, Chair Photoacoustic computed tomography (PACT), also known as optoacoustic or thermoacoustic tomography, is a rapidly emerging hybrid imaging modality that combines optical image contrast with ultrasound detection. The majority of currently available PACT image reconstruction algorithms are based on idealized imaging models that assume a lossless and acoustically homogeneous medium. However, in many applications of PACT these assumptions are violated and the induced photoacoustic (PA) wavefields are scattered and absorbed as they propagate to the receiving transducers. In those applications of PACT, the reconstructed images can contain significant distortions and artifacts if the inhomogeneous acoustic properties of the object are not accounted for in the reconstruction algorithm. In this dissertation, we develop and investigate a full-wave approach to iterative image reconstruction in PACT with acoustically heterogeneous lossy media. A key contribution of this work is the establishment of a discrete imaging model that is based on the exact PA wave

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