Mechanisms of unpinning and termination of ventricular tachycardia

High-energy defibrillation shock is the only therapy for ventricular tachyarrhythmias. However, because of adverse side effects, lowering defibrillation energy is desirable. We investigated mechani...

[1]  N. Trayanova,et al.  The role of cardiac tissue structure in defibrillation. , 1998, Chaos.

[2]  J. Thomas,et al.  Left atrial appendage "stunning" after electrical cardioversion of atrial flutter: an attenuated response compared with atrial fibrillation as the mechanism for lower susceptibility to thromboembolic events. , 1997, Journal of the American College of Cardiology.

[3]  V. Fast,et al.  Activation of cardiac tissue by extracellular electrical shocks: formation of 'secondary sources' at intercellular clefts in monolayers of cultured myocytes. , 1998, Circulation research.

[4]  B. Roth,et al.  Experimental and Theoretical Analysis of Phase Singularity Dynamics in Cardiac Tissue , 2001, Journal of cardiovascular electrophysiology.

[5]  W. Krassowska,et al.  The induction of reentry in cardiac tissue. The missing link: How electric fields alter transmembrane potential. , 1998, Chaos.

[6]  I Kodama,et al.  Aftereffects of high-intensity DC stimulation on the electromechanical performance of ventricular muscle. , 1994, The American journal of physiology.

[7]  I. Efimov,et al.  Fluorescent Imaging of a Dual-Pathway Atrioventricular-Nodal Conduction System , 2001, Circulation research.

[8]  J. Ruskin,et al.  Relation between shock-related myocardial injury and defibrillation efficacy of monophasic and biphasic shocks in a canine model. , 1994, Circulation.

[9]  P. Cranefield,et al.  The Rate of Oxygen Uptake of Quiescent Cardiac Muscle , 1960, The Journal of general physiology.

[10]  M. Linden,et al.  Panic disorders and agoraphobia: Side effects of treatment with an implantable cardioverter/defibrillator , 2004, Clinical cardiology.

[11]  I. Efimov,et al.  Pinning force in active media. , 2004, Physical review letters.

[12]  W. Stevenson,et al.  Dysrhythmias after direct-current cardioversion. , 1986, The American journal of cardiology.

[13]  Douglas S Lee,et al.  Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis. , 2003, Journal of the American College of Cardiology.

[14]  J. Merino,et al.  Randomized, prospective comparison of four burst pacing algorithms for spontaneous ventricular tachycardia. , 1998, The American journal of cardiology.

[15]  Mark-Anthony Bray,et al.  Considerations in phase plane analysis for nonstationary reentrant cardiac behavior. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[16]  M. Josephson,et al.  ELECTROCARDIOGRAPHY Electrocardiographic changes after cardioversion of ventricular arrhythmias , 2005 .

[17]  R. Lazzara,et al.  Analysis of Troponin I Levels After Spontaneous Implantable Cardioverter Defibrillator Shocks , 2002, Journal of cardiovascular electrophysiology.

[18]  R. Ideker,et al.  Reduction in Atrial Defibrillation Threshold by a Single Linear Ablation Lesion , 2001, Journal of cardiovascular electrophysiology.

[19]  Mark-Anthony Bray,et al.  Use of topological charge to determine filament location and dynamics in a numerical model of scroll wave activity , 2002, IEEE Transactions on Biomedical Engineering.

[20]  L. Tung,et al.  Dose-dependent reduction of cardiac transmembrane potential by high-intensity electrical shocks. , 1997, American journal of physiology. Heart and circulatory physiology.

[21]  V. Krinsky,et al.  Interaction of rotating waves in an active chemical medium , 1983 .

[22]  H. Trappe,et al.  Clinical Efficacy and Safety of the New Cardioverter Defibrillator Systems , 1993, Pacing and clinical electrophysiology : PACE.

[23]  J E Saffitz,et al.  Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia , 2000, Circulation research.

[24]  I R Efimov,et al.  The role of electroporation in defibrillation. , 2000, Circulation research.

[25]  V. Krinsky,et al.  Unpinning of a rotating wave in cardiac muscle by an electric field. , 1999, Journal of theoretical biology.

[26]  P. Tchou,et al.  Transmembrane Voltage Changes Produced by Real and Virtual Electrodes During Monophasic Defibrillation Shock Delivered by an Implantable Electrode , 1997, Journal of cardiovascular electrophysiology.

[27]  R. Gray,et al.  Spatial and temporal organization during cardiac fibrillation , 1998, Nature.

[28]  R. Luceri,et al.  Changing Trends in Therapy Delivery with a Third Generation Noncommitted Implantable Defibrillator: Results of a Large Single Center Clinical Trial , 1993, Pacing and clinical electrophysiology : PACE.

[29]  W. Baxter,et al.  Spiral waves of excitation underlie reentrant activity in isolated cardiac muscle. , 1993, Circulation research.

[30]  P. Friedman,et al.  Cardiac Pacing and Defibrillation: A Clinical Approach , 2000 .

[31]  Michael O. Sweeney,et al.  Prospective Randomized Multicenter Trial of Empirical Antitachycardia Pacing Versus Shocks for Spontaneous Rapid Ventricular Tachycardia in Patients With Implantable Cardioverter-Defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies (PainFREE Rx II) Trial Results , 2004, Circulation.

[32]  N S Peters,et al.  Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. , 1997, Circulation.

[33]  E. Donoso,et al.  Ventricular arrhythmias after precordial electric shock. , 1967, American heart journal.

[34]  I R Efimov,et al.  Evidence of Three‐Dimensional Scroll Waves with Ribbon‐Shaped Filament as a Mechanism of Ventricular Tachycardia in the Isolated Rabbit Heart , 1999, Journal of cardiovascular electrophysiology.

[35]  K. Lee,et al.  A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. , 1999, The New England journal of medicine.

[36]  P. Wolf,et al.  Epicardial mapping of ventricular defibrillation with monophasic and biphasic shocks in dogs. , 1993, Circulation research.

[37]  R. Hauer,et al.  ICD: a qualitative study of patient experience the first year after implantation. , 2004, Journal of clinical nursing.

[38]  H. Mond,et al.  Left atrial mechanical function after brief duration atrial fibrillation. , 1999, Journal of the American College of Cardiology.

[39]  J. Ruskin,et al.  Transient Right Bundle Branch Block Causing R Wave Attenuation Postdefibrillation , 1997, Pacing and clinical electrophysiology : PACE.

[40]  I. Efimov,et al.  Unpinning and removal of a rotating wave in cardiac muscle. , 2004, Physical review letters.