Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress.

[1]  A. Xue,et al.  Aberrant endoplasmic reticulum stress mediates coronary artery spasm through regulating MLCK/MLC2 pathway , 2018, Experimental cell research.

[2]  K. Choy,et al.  3′,4′-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice , 2018, Scientific Reports.

[3]  Cheuk-Man Yu,et al.  Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism , 2017, Toxicology and applied pharmacology.

[4]  T. Iwama,et al.  Effects of ticagrelor in a mouse model of ischemic stroke , 2017, Scientific Reports.

[5]  Min Chul Kim,et al.  Effects of ticagrelor on neointimal hyperplasia and endothelial function, compared with clopidogrel and prasugrel, in a porcine coronary stent restenosis model. , 2017, International journal of cardiology.

[6]  J. Cho,et al.  Comparison of Ticagrelor Versus Prasugrel for Inflammation, Vascular Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Requiring Coronary Stenting: A Prospective, Randomized, Crossover Trial. , 2017, JACC. Cardiovascular interventions.

[7]  K. Choy,et al.  Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress , 2017, PloS one.

[8]  R. Lavi,et al.  Effect of Ticagrelor Versus Clopidogrel on Vascular Reactivity. , 2017, Journal of the American College of Cardiology.

[9]  Dustin M. Lee,et al.  Endoplasmic reticulum stress and the development of endothelial dysfunction. , 2017, American journal of physiology. Heart and circulatory physiology.

[10]  Soo-Kyoung Choi,et al.  Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats , 2016, Scientific Reports.

[11]  R. Guieu,et al.  Pleiotropic effects of ticagrelor: Myth or reality? , 2016, Archives of cardiovascular diseases.

[12]  Soo-In Yeon,et al.  Inhibition of endoplasmic reticulum stress improves coronary artery function in type 2 diabetic mice , 2016, Experimental physiology.

[13]  Li Sun,et al.  Geraniol improves endothelial function by inhibiting NOX-2 derived oxidative stress in high fat diet fed mice. , 2016, Biochemical and biophysical research communications.

[14]  R. Guieu,et al.  Ticagrelor Improves Peripheral Arterial Function in Acute Coronary Syndrome Patients: Relationship With Adenosine Plasma Level. , 2016, Journal of the American College of Cardiology.

[15]  M. Mustafa,et al.  Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor , 2015, PloS one.

[16]  Y. Olgar,et al.  Effects of Ticagrelor on Ionic Currents and Contractility in Rat Ventricular Myocytes , 2015, Cardiovascular Drugs and Therapy.

[17]  Z. Bian,et al.  Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress , 2015, Scientific Reports.

[18]  R. Guieu,et al.  Ticagrelor increases endothelial progenitor cell level compared to clopidogrel in acute coronary syndromes: A prospective randomized study. , 2015, International journal of cardiology.

[19]  Y. Birnbaum,et al.  Chronic Treatment With Ticagrelor Limits Myocardial Infarct Size: An Adenosine and Cyclooxygenase-2–Dependent Effect , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[20]  R. Schulz,et al.  Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance. , 2014, Journal of the American College of Cardiology.

[21]  J. Pollock,et al.  Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. , 2014, American journal of physiology. Renal physiology.

[22]  N. Jenkins,et al.  Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1. , 2013, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[23]  Kathryn M. Spitler,et al.  Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat. , 2013, American journal of physiology. Heart and circulatory physiology.

[24]  E. Navarese,et al.  Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: a placebo-controlled study in rats. , 2012, Thrombosis research.

[25]  B. Lévy,et al.  C/EBP Homologous Protein-10 (CHOP-10) Limits Postnatal Neovascularization Through Control of Endothelial Nitric Oxide Synthase Gene Expression , 2012, Circulation.

[26]  G. Desideri,et al.  Cardiovascular risk and endothelial dysfunction: the preferential route for atherosclerosis. , 2011, Current pharmaceutical biotechnology.

[27]  I. Komuro,et al.  Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. , 2010, Circulation research.

[28]  E. Inscho,et al.  Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats. , 2010, Clinical science.

[29]  Claes Held,et al.  Ticagrelor versus clopidogrel in patients with acute coronary syndromes. , 2009, The New England journal of medicine.

[30]  D. Ron,et al.  Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. , 2009, Cell metabolism.

[31]  K. Kataoka,et al.  Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Hypertensive Rats, Independently of Blood Pressure , 2007, Stroke.

[32]  N. Mochizuki,et al.  Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome , 2007, Circulation.

[33]  R. Kaufman,et al.  The mammalian unfolded protein response. , 2003, Annual review of biochemistry.

[34]  J. Farmer,et al.  The renin angiotensin system as a risk factor for coronary artery disease , 2001, Current atherosclerosis reports.

[35]  Shokei Kim,et al.  Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. , 2000, Pharmacological reviews.