Effects of maleimide-polyethylene glycol-modified human hemoglobin (MP4) on tissue necrosis in SKH1-hr hairless mice

[1]  A. Malavalli,et al.  Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. , 2007, Translational research : the journal of laboratory and clinical medicine.

[2]  M. Rücker,et al.  Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance. , 2007, Clinical science.

[3]  R. Winslow,et al.  A Multicenter Clinical Study of the Safety and Activity of Maleimide-Polyethylene Glycol–modified Hemoglobin (Hemospan®) in Patients Undergoing Major Orthopedic Surgery , 2006, Anesthesiology.

[4]  A. Malavalli,et al.  Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates. , 2006, The Biochemical journal.

[5]  M. Rücker,et al.  Experimental cooling‐induced preconditioning attenuates skin flap failure , 2005, The British journal of surgery.

[6]  O. Habler,et al.  Künstliche Sauerstoffträger als Alternative zur Bluttransfusion , 2005, Der Anaesthesist.

[7]  R. Winslow,et al.  Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin. , 2005, American journal of physiology. Heart and circulatory physiology.

[8]  S. Langer,et al.  New model for in vivo investigation after microvascular breakdown in burns: use of intravital fluorescent microscopy. , 2005, Burns : journal of the International Society for Burn Injuries.

[9]  R. Winslow.  Targeted O2 Delivery by Low-p50 Hemoglobin: A New Basis for Hemoglobin-based Oxygen Carriers , 2005, Artificial cells, blood substitutes, and immobilization biotechnology.

[10]  O. Habler,et al.  [Artificial oxygen carriers as an alternative to red blood cell transfusion]. , 2005, Der Anaesthesist.

[11]  À. Franch,et al.  Induction of Colitis in Young Rats by Dextran Sulfate Sodium , 2005, Digestive Diseases and Sciences.

[12]  R. Winslow,et al.  A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol. , 2005, Haematologica.

[13]  A. Malavalli,et al.  Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). , 2004, Journal of applied physiology.

[14]  K. Messmer,et al.  Influence of platelet‐derived growth factor on microcirculation during normal and impaired wound healing , 2003, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[15]  G. Kramer.  Counterintuitive red blood cell substitute--polyethylene glycol-modified human hemoglobin. , 2003, Critical care medicine.

[16]  R. Winslow,et al.  Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. , 2003, Critical care medicine.

[17]  A. Malavalli,et al.  MP4, a new nonvasoactive PEG‐Hb conjugate , 2003, Transfusion.

[18]  M. Menger,et al.  Skin microvascular adaptations during maturation and aging of hairless mice. , 2000, American journal of physiology. Heart and circulatory physiology.

[19]  M. Rücker,et al.  In vivo analysis of the microcirculation of osteomyocutaneous flaps using fluorescence microscopy. , 1999, British journal of plastic surgery.

[20]  A. Greenburg,et al.  Cell-free hemoglobin preserves renal function during normothermic ischemia. , 1998, The Journal of surgical research.

[21]  T Klyscz,et al.  [Cap image--a new kind of computer-assisted video image analysis system for dynamic capillary microscopy]. , 1997, Biomedizinische Technik. Biomedical engineering.

[22]  M. Quintel,et al.  Hemoglobin solutions. , 1997, Acta anaesthesiologica Scandinavica. Supplementum.

[23]  R. Winslow,et al.  Fluid resuscitation with O2 vs. non-O2 carriers after 2 h of hemorrhagic shock in conscious hamsters. , 1997, The American journal of physiology.

[24]  K. Messmer,et al.  Adenosine inhibits postischemic leukocyte-endothelium interaction in postcapillary venules of the hamster. , 1991, The American journal of physiology.

[25]  K. Messmer,et al.  Reduction of postischemic reperfusion injury by the vasoactive drug buflomedil. , 1991, Blood vessels.

[26]  K. Messmer,et al.  Direct monitoring of capillary perfusion following normovolemic hemodilution in an experimental skin-flap model. , 1990, Plastic and reconstructive surgery.

[27]  K Messmer,et al.  Direct monitoring of nutritive blood flow in a failing skin flap: the hairless mouse ear skin-flap model. , 1989, Plastic and reconstructive surgery.

[28]  C. Kerrigan.  Skin Flap Failure: Pathophysiology , 1983, Plastic and reconstructive surgery.

[29]  R. Benner,et al.  Leukocyte Mobilization In Mice By Polyanions Decline of Leukocyte Mobilizing Capacity After Transplantation of Lymphoma , 1981, Cell and tissue kinetics.

[30]  C. Sterling.  Lymphocytosis in rats treated with polyacids. , 1979, Lymphology.

[31]  J. Arnold,et al.  A clinical safety trial of stroma‐free hemoglobin , 1978, Clinical pharmacology and therapeutics.