erapy alone in t of tumor size an

Summary This retrospective study involved 3 19 non-operable breast cancer patients treated by rddiOthXipy alone with doses of 65 Gy at the Institut Gustave-Roussy (IGR). These patients either had operable tumors but were unfit for general anesthesia or had inoperable tumors dur tn local contraindications. Most of them had advanced tumors: 21% < 7 cm; XL N, or N,; 30% with ierRammatory carcinomas. The 5- and lo-year survival was 40 and 19%, respectively. The local and distant relapse-free rate was 56 and 33% at 5 years and 44 and 28% at 10 years respectively. Results were analyzed according to tumor size, clinical node involvement, histologic grade, age, skin invasion and tumor dose. A multivariate analysis demonstrated that tumor size @ = 10m3) and histological grade (HG) 01 = lo-‘) were both significant factors predicting local relapse. Histological grade (p = IO-‘), tumor size (p = 10T2) and clinical node involvement (p = lo-‘) were the most significant factors predicting distant relapses. An individual risk (IR) of local recurrence and of distant recurrence was d&cd according to the above factors and was demonstrated to be good prognostic index. Tumor doses above 80 Gy did not increase local control. We recommend the general use of histological grading as it seems important for prediction of local and distant control in patients treated by radiotherapy alone.